Box-like Molecules-Induced Discrete Ring-in-Rings Assembly of Hydrogen-Bonded Aramide Macrocycles.

The controlled formation of ring-in-ring(s) assemblies is highly desirable as precursors for constructing high order supramolecular architectures. We report our findings that this goal can be achieved by balancing molecular structures and conformational adaptivity through an interplay of multiple non-covalent bonding interactions. With H-bonded aramide macrocycles and box-like molecules including naph-Box, m-Box and p4p-Box, ring-in-rings assembling systems with 4 : 1 stoichiometry are preferentially created.

Spontaneous Anionic Double Capture/Displacement to Trigger Single-Ion Conducting Interpenetrating Polymer Networks with Desired Ionic Conductivity for Durable Zn Metal Batteries.

The engineering of single-ion conductors (SICs) is a promising strategy to stabilize the anode/electrolyte interface in zinc-ion batteries. However, the commonly employed single-ion conductive solid or quasi-solid electrolytes often lead to a significant reduction in overall ionic conductivity, thereby impeding ion diffusion kinetics. Here, we propose a compromise strategy that effectively balances ionic conductivity and ion transference number.

Application of TransUnet Deep Learning Model for Automatic Segmentation of Cervical Cancer in Small-Field T2WI Images.

Effective segmentation of cervical cancer tissue from magnetic resonance (MR) images is crucial for automatic detection, staging, and treatment planning of cervical cancer. This study develops an innovative deep learning model to enhance the automatic segmentation of cervical cancer lesions. We obtained 4063 T2WI small-field sagittal, coronal, and oblique axial images from 222 patients with pathologically confirmed cervical cancer.

Spleen volume in relation to ulcerative colitis and Crohn's disease: a Mendelian randomization study.

Prior research has established the significance of spleen volume (SV) in the pathogenesis and advancement of ulcerative colitis (UC) and Crohn's disease (CD). Nevertheless, these investigations are predominantly observational, thereby leaving their causal associations ambiguous. Moreover, the breadth of existing research is constrained by various uncontrollable variables in clinical settings.

 (Fabaceae), a new species from riparian meadows of Yangtze River basin, China.

(Fabaceae), from Yangtze River basin, China, is described and illustrated as a new species. It is a dwarf shrublet occurring in the riparian meadows along the banks of rivers and lakes. It is morphologically similar to , , and , but differs by its prostrate or decumbent habit, angulate but not furrowed stems, and small stipules (ca.

Tunning "closed-loop" pockets for constructing stabilized structures of nanobody in the detection of procymidone under a broad range of pH value.

The tolerance advantages of nanobodies (Nbs) provide a new proposal for enhancing the stability and sensitivity of immunosensors. However, the tolerance of Nbs to extreme pH levels, has not been deeply investigated, as previous stability studies on Nbs had primarily focused on temperature and organic solvents. Here, a nanobody clone (NbFM5) is obtained and its tolerance is analyzed using molecular simulation and molecular docking.

Shengjiang Xiexin Decoction ameliorates DSS-induced ulcerative colitis via activating Wnt/β-Catenin signaling to enhance epithelium renovation and modulating intestinal flora.

Background: Shengjiang Xiexin Decoction (SJXXD) is a recognized formulation in traditional Chinese medicine that is commonly employed in diarrhea treatment. It has the potential to be a viable alternative for treating ulcerative colitis (UC), but its therapeutic effects and mechanisms remain unclear.

Purpose: This study aims to explore the effects and underlying mechanism of SJXXD in a mouse model of UC induced by dextran sulfate sodium (DSS).

Establishment of an HPLC Fingerprint and Cluster Analysis for Miao Ethnic Medicine .

, a traditional Miao medicine, is commonly used by the renowned national-level Chinese Traditional Medicine practitioner Zhengshi Wu for the treatment of diarrhea due to its strong antioxidative, anti-inflammatory, and antidiarrheal effects. This study aimed to establish a high-performance liquid chromatography (HPLC) fingerprint for to provide new evidence and technical means for the scientific evaluation and effective quality control of . The procedure involved isolation with a Nano ChromCore C18 column (250 mm × 4.

Assessing inflammatory protein factors in inflammatory bowel Disease using multivariable mendelian randomization.

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), decreases quality of life and causes disability. The underlying processes are not fully understood. This study uses Mendelian randomization (MR) analysis to identify cytokines that may be associated with UC and CD, aiding in early diagnosis and treatment decisions.

Rheological comparison of sputum and reconstituted airway epithelium mucus.

Pulmonary mucus serves as a crucial protective barrier in the respiratory tract, defending against pathogens and contributing to effective clearance mechanisms. In Muco Obstructive Pulmonary Diseases (MOPD), abnormal rheological properties lead to highly viscous mucus, fostering chronic infections and exacerbations. While prior research has linked mucus viscoelasticity to its mucin content, the variability in MOPD patients implies the involvement of other factors.

Vitexin alleviates MNNG-induced chronic atrophic gastritis via inhibiting NLRP3 inflammasome.

Ethnopharmacological Relevance: The dried fruit of Crataegus pinnatifida Bunge (Hawthorn in Chinese) is a traditional medicine used in China, Japan and Korea for thousands of years. Hawthorn is documented in the Chinese Pharmacopoeia, as a folk medicine that is used to eliminate food, strengthen the stomach, move qi and dissipate blood stasis, treat stagnation of meat and food, gastric distention and fullness, and has anti-inflammatory effects. Vitexin, a flavonoid glycoside, is an important biologically active compound derived from Hawthorn, with significant antioxidant and anti-inflammatory properties.

Pilot Study of Acute and Subchronic Oral Toxicological Biosafety Evaluation of Resorcinol-Formaldehyde Aerogel Nanomaterial in Kunming Mice.

Resorcinol-formaldehyde aerogel (RFa) is a unique nanomaterial composed of polymer nanoparticles with a three-dimensional network structure. Our previous studies have demonstrated its application in the separation and purification of alkaloids, and we are exploring its application potential as the drug delivery carrier. Therefore, it is necessary to comprehensively understand the in vivo toxicity profile of RFa and evaluate its oral biosafety.

Development of Broad-Spectrum β-Cyclodextrins-Based Nanomaterials Against Influenza Viruses.

In recent decades, epidemics and pandemics have multiplied throughout the world, with viruses generally being the primary responsible agents. Among these, influenza viruses play a key role, as they potentially cause severe respiratory distress, representing a major threat to public health. Our study aims to develop new broad-spectrum antivirals against influenza to improve the response to viral disease outbreaks.

High-quality genome assembly and annotation of the crested gecko (Correlophus ciliatus).

Correlophus ciliatus, or the crested gecko, is widely kept as a pet in many countries around the world due to its ease to care and bred and its high survival rate. However, there is limited number of genomic studies on the crested gecko. In this study, we generated a high-quality chromosome-level genome assembly of the crested gecko by combining Nanopore, Illumina, and Hi-C data.

Mechanical effect of taper position in abutment hole and screw taper angles on implant system and peri-implant tissue: a finite element analysis.

Purpose: The study aimed to investigate the mechanical effects of the taper position in the abutment hole and the screw taper angles on the implant system and peri-implant tissue using finite element analysis.

Methods: Four taper positions (L1, L2, L3, L4) in the abutment hole were established using 3D software and five screw taper angles (30°, 60°, 90°, 120°, 180°) were set.

Result: Taper position significantly affects the stresses in the implant system.

The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells.

Conventional dendritic cells (cDCs) generate protective cytotoxic T lymphocyte (CTL) responses against extracellular pathogens and tumors. This is achieved through a process known as cross-presentation (XP), and, despite its biological importance, the mechanism(s) driving XP remains unclear. Here, we show that a cDC-specific pore-forming protein called apolipoprotein L 7C (APOL7C) is up-regulated in response to innate immune stimuli and is recruited to phagosomes.

Comparative Analysis of the Safety and Feasibility of Laparoscopic Versus Open Segment 7 Hepatectomy.

Background: Laparoscopic hepatectomy has been widely accepted owing to its advantages as a minimally invasive surgery; however, laparoscopic segment 7 (S7) hepatectomy (LSH) has been rarely reported. We aimed to explore the safety and feasibility of LSH by comparing it with open surgical approaches.

Methods: Twenty-nine patients who underwent S7 hepatectomy between January 2016 and January 2023 were enrolled in this study.

"Two zones and three centers" distribution and suitable areas shift of an evergreen oak in subtropical China under climate scenarios.

Understanding the impact of climate change on the geographical distribution of species is a fundamental requirement for biodiversity conservation and resource management. , an evergreen oak endemic to China, plays a crucial role in maintaining the ecological stability in subtropical regions and high economic value attributed to its dark and high-density heartwood, but the existing resources are close to endangered. Currently, limited knowledge exists regarding its distribution and potential influences of climate change on suitable areas.

Carbon footprint analysis of wastewater treatment processes coupled with sludge in situ reduction.

The goal of this study was to assess the impacts or benefits of sludge in situ reduction (SIR) within wastewater treatment processes with relation to global warming potential in wastewater treatment plants, with a comprehensive consideration of wastewater and sludge treatment. The anaerobic side-stream reactor (ASSR) and the sludge process reduction activated sludge (SPRAS), two typical SIR technologies, were used to compare the carbon footprint analysis results with the conventional anaerobic - anoxic - oxic (AAO) process. Compared to the AAO, the ASSR with a typical sludge reduction efficiency (SRE) of 30 % increased greenhouse gas (GHG) emissions by 1.