Vitreous Metastasis in a Case of Metastatic Breast Cancer.

A 35-year-old female with a history of metastatic breast cancer (BC) presented with unilateral blurred vision and floaters over 6 weeks. Examination findings showed vitreous opacities and a vasculitis concerning for an infectious process. Diagnostic vitrectomy revealed no infectious cause, but rather metastatic cells in the vitreous, with no obvious retinal or choroidal metastatic focus.

Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Ageing hallmarks exhibit organ-specific temporal signatures.

Ageing is the single greatest cause of disease and death worldwide, and understanding the associated processes could vastly improve quality of life. Although major categories of ageing damage have been identified-such as altered intercellular communication, loss of proteostasis and eroded mitochondrial function-these deleterious processes interact with extraordinary complexity within and between organs, and a comprehensive, whole-organism analysis of ageing dynamics has been lacking. Here we performed bulk RNA sequencing of 17 organs and plasma proteomics at 10 ages across the lifespan of Mus musculus, and integrated these findings with data from the accompanying Tabula Muris Senis-or 'Mouse Ageing Cell Atlas'-which follows on from the original Tabula Muris.

Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report a striking buildup of lipid droplets in microglia with aging in mouse and human brains. These cells, which we call 'lipid-droplet-accumulating microglia' (LDAM), are defective in phagocytosis, produce high levels of reactive oxygen species and secrete proinflammatory cytokines.

Undulating changes in human plasma proteome profiles across the lifespan.

Aging is a predominant risk factor for several chronic diseases that limit healthspan. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets. Blood from young mice reverses aspects of aging and disease across multiple tissues, which supports a hypothesis that age-related molecular changes in blood could provide new insights into age-related disease biology.

Efficient Organic Light-Emitting Diodes Based on Indeno-Type Polyaromatic Hydrocarbons.

To develop the efficient emitters for organic light-emitting diode (OLED), three indeno-type polyaromatic hydrocarbons materials were designed and synthesized through Buchwald-Hartwig amination. OLED devices using these materials were fabricated in the following sequence: indium-tin-oxide (ITO) (180 nm)/'-diphenyl-'-(2-napthyl)-(1,1'-phenyl)-4,4'-diamine (NPB) (50 nm)/Emitting materials () (30 nm)/4,7-diphenyl-1,10-phenanthroline (BPhen) (30 nm)/lithium quinolate (Liq) (2 nm)/Al (100 nm). All devices showed the efficient emissions.

Studies on Organic Light Emitting Diodes Using Phenanthroline Derivatives as Emitters.

In this study, we designed and synthesized blue emitting materials based on 1, 10-phenanthroline derivatives. OLED devices using these materials were fabricated in the following sequence; indium-tin-oxide (ITO) (180 nm)/,'-diphenyl-,'-(2-napthyl)-(1,1'-phenyl)-4,4'-diamine (NPB) (50 nm)/Tris(4-carbazoyl-9-ylphenyl)amine (TCTA) (10 nm)/Blue materials (20 nm)/2,2',2″-(1,3, 5-Benzinetriyl)-tris(1-phenyl-1--benzimidazole) (TPBi) (30 nm)/lithium quinolate (Liq) (2 nm)/Al (100 nm). Particularly, a device using 2-(4-(9,9-dimethylacridin-10(9H)-yl)phenyl)-1-phenyl-1Himidazo[ 4,5-f][1,10] phenanthroline as a blue emitter showed the maximum values of luminous efficiency, power efficiency, and external quantum efficiency of 1.

Indenophenanthrene Derivatives for Highly Efficient Blue Organic Light-Emitting Diodes.

In this study, we designed and synthesized three fluorescent blue emitting materials based on indenophenanthrene derivatives. These derivatives were synthesized by Suzuki coupling reaction. Particularly, a device using 9,10-bis(9,9-dimethyl-9H-indeno[2,1-l]phenanthren-11-yl)anthracene as blue emitter showed maximum values of luminous efficiency, power efficiency, and external quantum efficiency of 7.

Synthesis of Benzo[g]quinoline Derivatives and Their Electroluminescent Properties.

Two fluorescent benzo[g]quinoline derivatives were synthesized via Friedländer synthesis. Multilayered OLEDs using benzo[g]quinoline derivatives as the emitters showed unexpected emissions by electroplexes. Particularly, a device using 2-(naphthalen-3-yl)-4-phenylbenzo[g]quinoline as an emitting material exhibited efficient emission with a luminous efficiency, a power efficiency, an external quantum efficiency, and CIE coordinates of 3.

Fabrication of Blue Organic Light-Emitting Diodes Based on Indeno-Phenanthrene/Triphenylene Amine Derivatives.

Among the three primary colors, blue-emitting materials are limited by the wide energy band gap. In this study, we designed and synthesized emitting materials based on indeno-phenanthrene/ triphenylene derivatives. Organic light emitting-diodes (OLEDs) using these materials were fabricated in the following sequence; ITO/,'-diphenyl-,'-(2-napthyl)-(1,1'-phenyl)-4,4'-diamine (NPB) (500 Å)/Blue materials (30 nm)/4,7-diphenyl-1,10-phenanthroline (BPhen) (30 nm)/lithium quinolate (Liq) (20 Å)/Al (1000 Å).

Highly Efficient Organic Light-Emitting Diodes Based on Naphthoanthracene Derivatives Containing Different Arylamines.

Herein, we designed and synthesized emitting materials based on naphthoanthracene with the different arylamino-substituents. Organic Light Emitting-Diodes (OLEDs) devices using these materials were fabricated in the following sequence; ITO/,'-diphenyl-,'-(2-napthyl)-(1,1'-phenyl)-4,4'- diamine (NPB) (500 Å)/Emitters (400 Å)/Alumium quinolate (Alq₃) (150 Å)/lithium quinolate (Liq) (20 Å)/Al (1000 Å). All devices showed efficient emissions.

Highly Efficient Blue Organic Light-Emitting Diodes Based on Diarylamine-Substituted Pyrene Derivatives.

In this study, we designed and synthesized three blue fluorescence materials based on diarylamine-substituted pyrene derivatives. Organic Light Emitting-Diodes devices using these materials were fabricated in the following sequence; ITO/2-TNATA (300 Å)/NPB (200 Å)/,-ADN: 10 wt% blue materials 1-3 (300 Å)/DNAB (300 Å)/Liq (20 Å)/Al (1000 Å). All devices showed highly efficient blue emissions.

Diphenylaminoarylvinyl-Substituted Diphenylanthracenes for Organic Light-Emitting Diodes.

Two blue fluorescent materials based on diphenylaminoarylvinyl-substituted diphenylanthracene have been synthesized. Multilayered organic light-emitting diodes (OLED) with the following sequence; ITO/NPB (50 nm)/Blue materials (30 nm)/Bphen (30 nm)/Liq (2 nm)/Al (100 nm) were fabricated using these materials as emitters. Two devices exhibited blue electroluminescence.

Synthesis and Electroluminescent Properties of Quinoline-Substituted Anthracene Derivatives for Organic Light-Emitting Diodes.

In this study, two anthracene derivatives with quinoline moieties were synthesized. To investigate their electroluminescent (EL) properties, multilayered OLEDs with the following sequence; indiumtin-oxide (ITO)/N, N'-di(1-naphthyl)-N, N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine (NPB) (20 nm)/Blue emitting materials (30 nm)/bathophenanthroline (Bphen) (30 nm)/lithium quinolate (Liq) (2 nm)/Al (100 nm) were fabricated using these materials as emitters. Two devices exhibited EL in blue to sky-blue regions.

Efficient Organic Light-Emitting Diodes Based on Naphthoanthracene Derivatives.

In this study, we designed and synthesized emitting materials based on naphthoanthracene derivatives. Organic Light Emitting-Diodes (OLEDs) devices using each four materials were fabricated. All devices showed efficient emissions.

Naphthalene Derivatives End-Capped with 2-(Diphenylamino)-9,9-Diethylfluorenes for Blue Organic Light-Emitting Diodes.

To investigate the electroluminescent (EL) properties of fluorescent materials based on fluorene-substituted naphthalene, multilayered OLEDs with the following sequence; indium- tin-oxide (ITO)/N,N'-di(1-naphthyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine (NPB) (50 nm)/Blue emitting materials (30 nm)/4,7-diphenyl-1,10-phenanthroline (Bphen) (30 nm)/lithium quinolate (Liq) (2 nm)/Al (100 nm) were fabricated using these materials as emitters. These devices exhibited blue emissions. Particularly, a device using 7-(1-(1-(2-(diphenylamino)-9,9-diethyl-9H-fluoren-7- yl)naphthalen-4-yl)naphthalen-4-yl)-9,9-diethyl-N,N-diphenyl-9H-fluoren-2-amine as a blue emitting material exhibited blue emission with a luminous efficiency, a power efficiency, an external quantum efficiency, and CIE coordinates of 2.

Optimum thickness of epsilon negative tri-metal layer electrodes for maximizing OLED outcoupling efficiency.

A transparent electrode is an essential component that has a strong influence on the extraction of light from organic light-emitting diodes (OLEDs) due to its effect on both electrical and optical performance. In this work, we present theoretical studies, full wave simulations, and experimental results to evaluate the influence of the thickness of epsilon negative tri-metal layer (TML) electrodes on the performance of red phosphorescent OLEDs (PHOLEDs) via an optical microcavity effect. The results show that the external quantum efficiency of the optimized TML-based red PHOLED of 17.

Blue organic light-emitting diodes based on fluorene-bridged quinazoline and quinoxaline derivatives.

Two blue emitters based on fluorene-bridged quinazoline and quinoxaline derivatives were prepared via the Suzuki reaction. Their photoluminescent properties were investigated. Furthermore, theoretical studies on these materials using the density functional theory calculation were conducted.

SURGICAL TREATMENT OF A MACULAR HOLE IN X-LINKED RETINOSCHISIS.

Purpose: To report a case of full-thickness macular hole in a patient with X-linked retinoschisis and the outcome after surgical repair.

Methods: A 15-year-old boy with a history of X-linked retinoschisis presented to his ophthalmologist for routine follow-up and was found to have a Stage-3 macular hole in his left eye. His vision was 20/200.

Tri-Metal Layered Semitransparent Electrode for Red Phosphorescent Organic Light-Emitting Diodes.

In this paper, we fabricated tri-metal layered thin film semitransparent electrodes consisting of a thin conductive metal layer, sandwiched between two nickel layers. An equal red phosphorescent organic light-emitting diode (PHOLED) structure was deposited on the anodes of indium tin oxide (ITO) and three types of tri-metal layers (Ni/Al/Ni, Ni/Cu/Ni, and Ni/Ag/Ni, thickness of 3/7/3 nm in common) on a glass substrate. The optical and electrical performances of the device using Ni/Ag/Ni were improved more than the performances of the other devices due to the micro-cavity effect in accordance with the various electrode characteristics.

Improved Performance of Red Phosphorescent Organic Light Emitting Diodes Using Partial Mixed Host System.

Phosphorescent organic light-emitting diodes (PHOLEDs) have shown a heterojunction system that is a bulk heterojunctioned emitting layer (EML). In our work, we have demonstrated an improvement in efficiency with a partial mixed host system in an EML. A mixed host system, which is mixed with a host material and an electron transporting material, was used on the red PHOLEDs.

Efficient blue organic light-emitting diodes using N(2) ,N(2) ,N(11) ,N(11) ,5,6,7,8-octaphenyltriphenylene-2,11-diamine derivatives.

In this study, we have synthesized phenyl-substituted triphenylene derivatives, using the Diels-Alder reaction and the Buchwald-Hartwig reaction. To investigate electroluminescence properties of these materials, multilayer organic light-emitting diode (OLED) devices were fabricated with a structure of indium-tin-oxide (ITO) (180 nm)/4,4'-bis(N-(1-naphthyl)-N-phenylamino)biphenyl (NPB) (50 nm)/blue-emitting materials (1-3) (30 nm)/bathophenanthroline (Bphen) (35 nm)/lithium quinolate (Liq) (2 nm)/Al (100 nm). A device using N(2) ,N(2) ,N(11) ,N(11) ,5,6,7-heptaphenyltriphenylene-2,11-diamine (2) exhibited efficient blue emission with luminous, power, and external quantum efficiencies of 0.

Optimization of Semitransparent Anode Electrode for Flexible Green and Red Phosphorescent Organic Light-Emitting Diodes.

In this paper, we demonstrated thin film semitransparent anode electrode using Ni/Ag/Ni (3/6/3 nm) on green and red phosphorescent OLEDs, which have basically high efficiency and good optical characteristics. Moreover, we applied this semitransparent anode on flexible green and red phosphorescent OLEDs, which were then optimized for possible applications on flexible substrates. First, we studied optimization using various conditions of Ni/Ag/Ni electrodes via transmittance and sheet resistance.

Blue Emitters Based on Anthracene-Aryl-Anthracene Moieties End-Capped with 1-Naphthyl Groups for Organic Light-Emitting Diodes.

We have designed emitters based on Anthracene-Aryl-Anthracene moieties end-capped with 1-naphthyl groups. In particular, a device showed blue EL properties with luminous and power efficiencies of 1.95 cd/A and 0.