Publications by authors named "Song Chun-Hua"
Objective: Qiliqiangxin Capsule (QL) was investigated for its possible role in cardiac hypertrophy in this study.
Methods: QL (0.5 mg/mL) was pre-treated in Neonatal Mouse Ventricular Cardiomyocytes (NMVCs) before induction of cardiomyocyte hypertrophy by Angiotensin II (Ang-II).
Article Synopsis
- This study investigated the calf proportion index (CPI) to assess its relationship with malnutrition and survival in overweight and obese cancer patients.
- The research included 3,499 patients and found that lower CPI values were correlated with higher mortality and greater risk of malnutrition, especially in obese individuals.
- The CPI proved to be a more effective predictor of survival than other measurements, and specific cut-off values were identified (0.65% for men, 0.57% for women) to determine risk levels.
Article Synopsis
- Older cancer patients face increased risks of malnutrition and decreased quality of life (QoL), prompting a study on the correlation between malnutrition and QoL using GLIM criteria for diagnosis.
- This study included over 5,300 older cancer patients, revealing that those with malnutrition had lower QoL scores, with severe malnutrition having the most significant impact on QoL.
- The findings indicated that both malnutrition and QoL are critical factors in predicting survival for older cancer patients, particularly for those with lung and gastric cancers.
Objectives: Systemic inflammation and skeletal muscle strength play crucial roles in the development and progression of cancer cachexia. In this study we aimed to evaluate the combined prognostic value of neutrophil-to-lymphocyte ratio (NLR) and handgrip strength (HGS) for survival in patients with cancer cachexia.
Methods: This multicenter cohort study involved 1826 patients with cancer cachexia.
Article Synopsis
- This study investigated the prognostic value of hepatic proteins (albumin, prealbumin, and transferrin) in predicting survival outcomes for patients with cancer cachexia, a condition marked by severe weight loss and muscle wasting.
- In a cohort of 1,303 patients, low levels of these proteins were associated with higher mortality rates, confirming their role as independent risk factors for long-term survival in various types of cancer.
- The findings highlighted that albumin was the strongest predictor of survival, especially in patients with certain cancers like upper gastrointestinal and colorectal types, emphasizing the importance of monitoring these protein levels in cancer care.
Article Synopsis
- Cancer cachexia is a serious condition affecting cancer patients with diverse clinical features, and identifying these phenotypes can lead to tailored treatments and improved patient outcomes.
- In a nationwide study conducted in China on 4,329 patients, researchers used machine learning to classify patients into four distinct clusters based on their clinical characteristics, which varied from mildly to severely impaired health.
- The study found that as the impairment severity increased, so did mortality rates, with the machine learning model performing better at predicting outcomes compared to traditional methods, confirming its effectiveness in classifying cancer cachexia phenotypes.
Purpose: Our study aimed to comprehensively analyze the association between anemia and systemic inflammation in older patients with cancer.
Methods: This multicenter prospective cohort study included 4955 older patients with cancer between 2013 and 2020. Logistic regression analysis was performed to investigate risk factors of anemia, reporting odds ratios (ORs), and 95% confidence intervals (CIs).
A promising prognostic grading system incorporating weight loss and inflammation in patients with advanced cancer.
J Cachexia Sarcopenia Muscle
December 2023
Background: Involuntary weight loss and increased systemic response are frequently observed in patients with cancer, especially in advanced stages. This study aimed to develop a powerful weight loss and inflammation grading system (WLAIGS) and investigate its prognostic performance in patients with advanced cancer.
Methods: This multicentre prospective cohort study included 11 423 patients with advanced cancer.
Background: Malnutrition and systemic inflammation are considered 2 hallmarks of cancer cachexia. Our study aimed to construct a modified Controlling Nutritional Status by introducing C-reactive protein as an inflammatory parameter and investigate its prognostic value in patients with cancer cachexia.
Methods: This multicenter cohort study included 5221 patients with cancer, among whom 1719 were diagnosed with cachexia.
Background: Malnutrition and increased systemic inflammatory responses are highly prevalent in patients with cancer and they have a negative effect on prognosis. We aimed to develop a nutrition-inflammation prognostic grading system (NIPGS) for patients with cancer, which incorporates the Nutritional Risk Screening 2002 (NRS 2002) and C-reactive protein (CRP) levels.
Methods: This multicenter retrospective cohort study totally included 6891 patients diagnosed with cancer.
Article Synopsis
- The study assessed sarcopenia (muscle loss) in a large group of cancer patients and its impact on prognosis, finding that 33% of 13,761 patients had sarcopenia.
- Age was identified as the most significant risk factor for sarcopenia, with those affected experiencing worse nutritional status and quality of life.
- Sarcopenia was linked to higher mortality rates in cancer patients, suggesting it is a critical consideration in managing cancer care.
Malnutrition is a common comorbidity among patients with cancer. However, no nutrition-screening tool has been recognized in this population. A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is needed.
View Article and Find Full Text PDFBackground: Changes in body composition and systemic inflammation are important characteristics of cancer cachexia. This multi-centre retrospective study aimed to explore the prognostic value of the combination of body composition and systemic inflammation in patients with cancer cachexia.
Methods: The modified advanced lung cancer inflammation index (mALI), which combines body composition and systemic inflammation, was defined as appendicular skeletal muscle index (ASMI) × serum albumin/neutrophil-lymphocyte ratio.
Hand grip strength-based cachexia index as a predictor of cancer cachexia and prognosis in patients with cancer.
J Cachexia Sarcopenia Muscle
February 2023
Background: The cachexia index is a useful predictor for cancer cachexia and prognostic assessment. However, its use is limited because of high testing costs and complicated testing procedures. Thus, in this study, we aimed to develop a hand grip strength (HGS)-based cancer cachexia index (H-CXI) as a potential predictor of cancer cachexia and prognosis in patients with cancer.
View Article and Find Full Text PDFBackground: Systemic inflammation and water composition are important factors affecting cancer prognosis. This study aimed to explore the association between the neutrophil-to-lymphocyte ratio (NLR) and intracellular water/total body water (ICW/TBW) ratio and overall survival (OS) in colorectal cancer (CRC).
Methods: This multicenter, prospective cohort included 628 patients with CRC between June 2012 and December 2019.
Background: Systemic inflammation is currently regarded as a hallmark of cancer. This study aimed to accurately clarify the prognostic value of various inflammatory markers in patients with stage IV cancer.
Methods: This study assessed 2,424 patients with cancer diagnosed with cancer in tumor, node, metastasis (TNM) stage IV.
Aims: Systemic inflammation plays an important role in cancer cachexia. However, among the systemic inflammatory biomarkers, it is unclear which has optimal prognostic value for cancer cachexia.
Methods: The Kaplan-Meier method was used and the log-rank analysis was performed to estimate survival differences between groups.
Objectives: Cancer cachexia is a systemic paraneoplastic phenomenon involving multiple organs, including the liver. Total bilirubin (TBIL) is an easily obtained blood biomarker that reflects liver homeostasis. The aim of this study was to evaluate the prognostic value of serum TBIL in patients with cancer cachexia.
View Article and Find Full Text PDFBackground And Aims: Systemic inflammation is the most representative host-tumor interaction in cancer. This study aimed to develop a novel inflammatory burden index (IBI) to assess the inflammatory burden of different cancers and predict the prognosis of patients with cancer.
Methods: A total of 6359 cancer patients admitted to multiple centers from 2012 through 2019 were included in this study.
Background: The body's immune-nutrition status affects prognosis in patients with lung cancer. The Controlling Nutritional Status (CONUT) score is an immune-nutrition-related index associated with prognosis in other tumors. We aimed to assess the value of CONUT scores in predicting prognosis in patients with lung cancer.
View Article and Find Full Text PDFBackground: This study was sought to report the prevalence of malnutrition in elderly patients with cancer. Validate the predictive value of the nutritional assessment tool (Patient-Generated Subjective Global Assessment Short Form, PG-SGA SF) for clinical outcomes and assist the therapeutic decision.
Methods: This is a secondary analysis of a multicentric, observational cohort study.
Article Synopsis
- A study was conducted to develop and validate a simplified version of the Patient-Generated Subjective Global Assessment (mPG-SGA) for cancer patients, aiming to reduce the time required to complete the assessment.
- Experts evaluated the existing PG-SGA for its clarity and difficulty, leading to a refined mPG-SGA that accurately categorizes nutritional status and predicts patient survival based on nutrition.
- Results showed that patients categorized by the mPG-SGA had significant differences in median overall survival, highlighting its effectiveness compared to the original PG-SGA and the abridged version.
Article Synopsis
- Malnutrition is prevalent among elderly cancer patients and correlates with negative health outcomes, with this study reporting malnutrition rates of 55.02% (CONUT), 58.70% (NRI), and 11.65% (PNI) among 1,494 participants.
- The study found that poorer nutritional status is linked to older age, lower body mass index (BMI), reduced hand grip strength, and advanced tumor stages, impacting overall survival and quality of life (QoL).
- Malnutrition significantly increases the risk of all-cause mortality, with malnourished individuals facing higher mortality incidence rates across the three scoring systems, further enhancing the predictive power of traditional cancer staging systems.
Background: Recently, albumin-globulin ratio (AGR), a serological indicator that reflects nutritional status and systemic inflammatory, has been reported to be associated with the prognosis of various cancers. However, there is currently no research report on its relationship with cancer cachexia.
Objectives: This study aimed to explore the prognostic value of AGR in patients with cancer cachexia through a multicenter retrospective analysis.
Article Synopsis
- Serum albumin levels correlate with 1-year mortality in cancer cachexia patients, suggesting its potential as a prognostic biomarker.
- A study matched 266 patients who survived less than 1 year with 266 who survived 1 year or more, analyzing the impact of albumin and total protein levels.
- Results indicated that higher albumin and total protein levels (especially in specific quartiles) significantly associated with improved 1-year survival rates, highlighting their clinical importance in managing cancer cachexia.