Publications by authors named "Soneha Datta"
Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells.
Invest Ophthalmol Vis Sci
November 2024
Purpose: The intraepithelial corneal nerves (ICNs) innervating the cornea are essential to corneal epithelial cell homeostasis. Rho-associated kinase (ROCK) inhibitors (RIs) have been reported to play roles in neuron survival after injury and in mitochondrial transfer between corneal epithelial cells. In this study, the mechanisms human corneal limbal epithelial (HCLE) cells use to control intercellular mitochondrial transfer are assessed.
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- The study investigates the role of rho kinase (ROCK) inhibitors in promoting the health of corneal nerves and their potential effect on nerve regeneration after injury.
- Researchers analyzed integrin and extracellular matrix expression in mouse neurons and explored how RI treatment influences neurite growth both in lab cultures and in live mice following injuries.
- Results showed that specific integrins were present on neuron growth structures, and RI treatment enhanced nerve growth in vitro and improved sensory nerve recovery in vivo after injury.