Use of Hydroxycobolamin in the Prevention of Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass: A Controlled Prospective Trial.

Objective: We hypothesized that the prophylactic use of hydroxocobalamin in patients at high-risk patients to develop vasoplegia after cardiopulmonary bypass (CPB) may decrease its incidence.

Design: This randomized placebo-controlled prospective single-center study was conducted on high-risk patients for vasoplegia who underwent coronary artery bypass grafting (CABG).

Setting: This study was conducted in Ain Shams University Hospitals from August 2019 to October 2023 in cardiothoracic operative rooms and its intensive care unit.