Publications by authors named "Sonali Karhana"
infection is linked to gastritis, ulcers and gastric cancer. Nanomedicine offers a promising solution by utilizing nanoparticles for precise drug delivery, countering antibiotic resistance and delivery issues. Nanocarriers such as liposomes and nanoparticles enhance drug stability and circulation, targeting infection sites through gastric mucosa characteristics.
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- Emerging studies suggest that benzimidazole-based anthelmintics (BBA) may have anticancer effects against lung cancer, but the exact mechanisms are not yet understood.
- Researchers utilized network pharmacology and molecular docking to identify potential molecular mechanisms and targets for BBA, gathering extensive data from various scientific databases to construct protein-protein interaction diagrams.
- The analysis identified key targets such as cyclin D1 and EGFR, with ricobendazole ranked as the most promising BBA for lung cancer treatment, indicating a need for further research in this area.
Topical application of BRAF inhibitors has been shown to accelerate wound healing in murine models, which can be extrapolated into clinical applications. The aim of the study was to identify suitable pharmacological targets of BRAF inhibitors and elucidate their mechanisms of action for therapeutic applicability in wound healing, by employing bioinformatics tools including network pharmacology and molecular docking. The potential targets for BRAF inhibitors were obtained from SwissTargetPrediction, DrugBank, CTD, Therapeutic Target Database, and Binding Database.
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- - Fungal infections are increasingly posing health risks, driving research for new therapeutic options and accelerating antifungal drug development.
- - Current antifungal treatments such as polyenes, azoles, echinocandins, and flucytosine have limitations, including toxicity and the risk of resistance, which affect their effectiveness and lead to serious health issues.
- - The article reviews existing therapies, their challenges, and highlights new treatment developments and clinical trials aimed at improving outcomes for fungal infections.
Objectives: Recipients of bone marrow transplant with COVID-19 are at high risk of mortality and morbidity from their underlying immunocompromised state. Graft-versus-host disease and other comorbidities lead to poor COVID-19 outcomes in these patients. Understanding the outcomes and clinical characteristics of bone marrow transplant recipients with COVID-19 is needed to devise potential life-saving therapies for patients with hematologic malignancies.
View Article and Find Full Text PDFQuantum dots (QDs) are semiconductor crystals in the nanodimension having unique optical and electronic properties that differ from bulk material due to quantum mechanics. The QDs have a narrow emission peak, size-dependent emission wavelength, and broad excitation range which can be utilized for diverse biomedical applications such as molecular imaging, biosensing, and diagnostic systems. This article reviews the current developments of biomedical applications of QDs with special reference to point-of-care testing.
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