Publications by authors named "Sonal G Patel"
Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid.
Amyotroph Lateral Scler Other Motor Neuron Disord
March 2004
Effective treatment for amyotrophic lateral sclerosis (ALS) remains elusive. Two of the primary hypotheses underlying motor neuron vulnerability are susceptibility to excitotoxicity and oxidative damage. There is rapidly emerging evidence that the cannabinoid receptor system has the potential to reduce both excitotoxic and oxidative cell damage.
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- A 42-year-old woman presented with hyperthyroidism and a large goiter, later developing hypothyroidism and severe neck pain. Biopsy indicated chronic thyroiditis and fibrosis, leading to treatments that included glucocorticoids and tamoxifen, resulting in some improvement.
- She later experienced severe paresthesia, a seizure, and compressive symptoms due to a massively enlarged thyroid that required emergency surgery (isthmusectomy), ultimately diagnosed as Riedel's thyroiditis.
- After treatment, her goiter reduced significantly and most symptoms improved; however, she still has persistent hypothyroidism and hypoparathyroidism, managing her condition with medication. This case highlights the complex nature of