Clinical spectrum in multiple families with primary COQ deficiency.

Coenzyme Q COQ , an essential cofactor in the electron-transport chain is involved in ATP production. Primary COQ deficiency is clinically and genetically a heterogeneous group of mitochondrial disorders caused by defects in the COQ synthesis pathway. Its mode of inheritance is autosomal recessive and it is characterized by metabolic abnormalities and multisystem involvement including neurological features.

Prophylactic furosemide infusion decreasing early major postoperative renal dysfunction in on-pump adult cardiac surgery: a randomized clinical trial.

Introduction: Acute renal dysfunction is a common complication of cardiac surgery. Furosemide is used in prevention, or treatment, of acute renal dysfunction. This study was conducted to evaluate the protective effects of intra- and early postoperative furosemide infusion on preventing acute renal dysfunction in elective adult cardiac surgery.