TGF-β1-induced Fascin1 promotes cell invasion and metastasis of human 786-0 renal carcinoma cells.

Objective: To investigate the effect of transforming growth factor-β1 (TGF-β1) on the expression of Fascin1 protein and its impact on cell invasion and metastasis in human renal carcinoma.

Methods: Renal tissue slices of 52 cases when undergoing radical nephrectomy were collected to be the observation group, and the normal renal tissues of 23 cases when undergoing nephrectomy due to trauma were collected to be the control group. The expressions of TGF-β1 and Fascin1 were measured by immunohistochemical staining.

High-Level Expression of microRNA-21 in Peripheral Blood Mononuclear Cells Is a Diagnostic and Prognostic Marker in Prostate Cancer.

Aims: Our study aimed to evaluate the diagnostic and prognostic values of microRNA-21 (miR-21) expression levels in peripheral blood mononuclear cells (PBMCs) for prostate cancer (PCa).

Methods: Between February 2010 and June 2014, 75 consecutive patients with localized PCa confirmed by radical prostatectomy and biopsy were enrolled as the case group. Among them, 25 patients were confirmed with recurrence or metastasis (R/M) (PCa with R/M group) and 50 patients without R/M (PCa without R/M group).

Doppler ultrasound measurement of resistance index in the diagnosis of prostate cancer.

Prostate cancer (PCa) remains the second leading cause of cancer diagnosis worldwide. Early diagnosis and treatment of PCa is critical since the long-term prognosis is excellent in patients with tumors confined to the prostate gland. The current meta-analysis investigates the diagnostic value of resistive index (RI) measurement using color Doppler ultrasound in patients with PCa.