Publications by authors named "Somthawin Aiempradit"
Article Synopsis
- DPYD polymorphisms are linked to toxicities from the chemotherapy drug 5-FU, and this study focused on identifying associations between specific DPYD gene variations and blood-related side effects in Thai colorectal cancer patients.
- Genetic testing revealed distinct frequencies of DPYD variants, with the homozygous variant DPYD*9A significantly correlating with neutropenia and other hematological toxicities during the first cycle of treatment.
- The findings suggest that the DPYD*5 variant may act as a predictive marker for lower toxicity levels, highlighting the importance of genetic profiling in managing 5-FU treatment risks.
Background: The two common methylenetetrahydrofolate reductase () polymorphisms 677G>A and 1298A>C may have been affecting 5-FU toxicity in cancer patients for decades. Drug efficacy has also been shown by previous studies to be affected. In this study, we investigated the effects of these polymorphisms on 5-FU hematological toxicity and treatment efficacy, to provide enhanced pharmacological treatment for cancer patients.
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