Publications by authors named "Somrita Padma"
Article Synopsis
- - Researchers isolated a new lectin, named hRTL, from a marine sponge, which belongs to the galectin family and shows high similarity to another galectin called CCL.
- - hRTL is a tetramer composed of 141 amino acids and features a unique 23 amino acid signal peptide that gets cleaved after translation, differing from most galectins which usually have acetylated modifications.
- - The hRTL lectin binds strongly to specific glycan structures and has been shown to induce cytotoxic effects in colorectal cancer cells expressing certain antigens, suggesting potential therapeutic implications.
Article Synopsis
- - SeviL, a lectin from mussels, has been shown to induce apoptosis in HeLa ovarian cancer cells and promote M1 polarization in macrophage cell lines at low concentrations.
- - Low levels of SeviL decrease the growth of monocyte and basophil cell lines but stimulate proliferation in RAW264.7 macrophages, evidenced by changes in cell shape and up-regulation of mitochondrial proteins.
- - Treatment with SeviL leads to increased secretion of pro-inflammatory cytokines and activation of various signaling pathways, indicating its role in regulating cell behaviors like proliferation and death in macrophages, which may impact immune responses in living organisms.
Article Synopsis
- The study investigates two new glycoconjugates, Z-P(Gly)-Glu and Z-F(4-N)-Glu, which can form effective self-healing gels in water and various organic solvents, highlighting their ambidextrous supergelator properties.
- Characterization revealed that these gelators exhibit β-sheet structures that lead to the formation of unique left-handed helical fibers, potentially useful for biomedical applications due to their benign and non-toxic nature.
- The research further demonstrates the gels' effectiveness in drug delivery, such as streptomycin, along with favorable cell compatibility and antimicrobial properties, paving the way for innovative therapeutic uses.
Ulcerative colitis (UC) is a chronic inflammatory manifestation of the human colon that is linked with colorectal cancer. Development of an appropriate animal model is crucial to study the immunopathophysiology of UC wherein chemical induction is the most popular method of choice. However, unavailability of an optimum experimental model limits the success of this method.
View Article and Find Full Text PDFColorectal cancer (CRC) is one of the most common cancers and is the second-highest in cancer-related deaths worldwide. The changes in gut homeostasis and microbial dysbiosis lead to the initiation of the tumorigenesis process. Several pathogenic gram-negative bacteria including are the principal contributors to the induction and pathogenesis of CRC.
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