Publications by authors named "Somova E"

The gastrovascular system of colonial hydroids is central to homeostasis, yet its functional biology remains poorly understood. A probe (2',7'-dichlorodihydrofluorescein diacetate) for reactive oxygen species (ROS) identified fluorescent objects at polyp-stolon junctions that emit high levels of ROS. A nuclear probe (Hoechst 33342) does not co-localize with these objects, while a mitochondrial probe (rhodamine 123) does.

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Examination of the numerous anomalies of the chromosomes 13, 18, 21, X, Y was carried out using FISH method before the IVF attempt in the patients with astheno-, oligo- and teratozoospermia. The percentage of aneuploid spermatozoa was magnificently higher (p < 0.05) in patients with oligozoospermia comparing with the ones with astheno- and teratozoospermia.

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The clinico-immunological effect and significance of the rectal and inhalation methods of the application of recombinant IFN-alpha2 with complex immunoglobulin preparation (CIP) in the treatment of relapsing bronchitis in children have been determined. The determination of the levels of interferon activity in buccal secretions and in venous blood permits the objective evaluation of the immune responsiveness of the body and the treatment effect. The immunocorrecting action of the combined immunobiological preparation (recombinant IFN-alpha2 and CIP) is manifested by an increased level of endogenic interferon and the stimulation of phagocytic activity.

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Apart from lymphadenopathy types observed in well-known diseases (oncology and hematology pathologies, systemic lesions of connective tissues, tuberculosis, brucellosis, infection mononucleosis, toxoplasmosis, AIDS and other specific processes), there is an extensive group of lymphadenopathy (up to 70% of all disease cases), whose cause cannot be diagnosed by using the routine examination schemes. This was reflected in the diagnosis of "lymphadenopathy of unverified etiology" according to the MKB-1 now in force. Investigations of the role (in etiopathogenesis) of unverified lymphadenopathy types as observed in children with the infection component as well as optimization of their diagnosis and treatment schemes are elucidated in the paper.

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Melatonin in low doses of (0.05 and 0.5 mg/kg) administered to senescent rats in winter and summer inhibited free radical oxidation and LPO.

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A study made in 77 patients with different form of thyropathy revealed increased blood plasma and erythrocyte content of lipid peroxidation products, such as diene conjugates and TBA-active producers. The plasma chemiluminescence got more intense as well. Different mechanisms for the lipid peroxidation activation in patients presenting with thyroid hormone abundance or deficiency have been analyzed.

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The processes of lipids free-radical oxidation in euthyroid and thyrotoxic tissue samples of human thyroid gland were studied. It was shown, that the content of TBA-active lipid peroxidation products was considerably increased in thyrotoxic tissue of the thyroid, and the activity of antioxidant enzymes (catalase, glutation peroxidase) was decreased in it. Possible mechanism of the tissue lipoperoxide alternation under conditions of the thyroid hyperfunction is discussed.

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In experiments with 933 (CBA x C57Bl)F1 mice it has been found that with any variant of alternation and sequence of single ionizing and SHF irradiation with lethal doses, the radiation affection caused by gamma quanta is aggravated. Preirradiation with gamma or SHF radiation ameliorates the severity of the affection caused by the subsequent SHF radiation. Parenteral injection of colloidal sulfur 60 min before SHF radiation causes a 2-5-fold increase in the survival rate of exposed and protected mice as compared to unprotected animals.

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A method of thermography of the hands including the cold test was employed to evaluate peripheral microcirculation in 116 patients (34 with atherosclerosis of the vessels of different sites, 38 with chronic diffuse liver diseases and 38 with chronic pancreatitis). In 29 patients with hepatocirrhosis and chronic pancreatitis microcirculation was also studied by conjunctival biomicroscopy. Microcirculatory disturbances by the method of thermography of the hands, particularly using the cold test, were revealed in a considerable number of cases of primary vascular pathology as well as in chronic liver and pancreatic diseases.

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In experiments on 80 Wistar male rats their motor activity was studied using "Optovarimex" device which permitted to register the position of animals in space. The rats were subjected to total-body gamma-irradiation with doses of 6.5, 13, 50 and 100 Gy.

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