Publications by authors named "Somesh Gupta"
Mycoplasma genitalium: An emerging superbug among men having sex with men.
Indian J Dermatol Venereol Leprol
January 2025
Thirteen children with xeroderma pigmentosum variant C were evaluated using the Dermoscopic Photoaging Assessment Scale (DPAS), the Glogau scale, and the Sun Protection Behavior Scale (SPBS). Most patients exhibited signs of epidermal photoaging, with pigmentary and vascular changes and poor sun protection behavior (mean SPBS score: 18.92 ± 5.
View Article and Find Full Text PDFLanger's lines, lines of cleavage, and biodynamic excisional skin tension (BEST) lines have been defined for cutaneous surgery to ensure excisional wound closure with the least tension on any part of the body and minimize scarring. This article describes nail unit incision lines (NUIL) with a similar perspective. NUIL are followed by nail surgeons to help regrowth of a normal nail; however, they are not widely understood or respected during nail surgery.
View Article and Find Full Text PDFBackground: Xeroderma pigmentosum (XP) is a genodermatosis, characterized both by premature aging and significantly increased risk of non-melanoma and melanoma skin cancers at an early age. However, limited literature is available on the common histopathological subtypes of basal cell carcinoma (BCC) in these patients.
Methods: In this ambispective case series, we recruited patients of XP who had either a currently present skin tumor or previously excised one, provided their histopathological sections were available.
A 45-year-old male presented with a 2-year history of erythematous indurated plaques on the right palate and adjacent palatobuccal mucosa, accompanied by dull pain and loosening of the third molar, necessitating extraction. Radiological imaging revealed soft tissue density with cortical bony erosions in the bilateral upper alveolar ridge. A single sub-centimetric right cervical lymph node was palpable.
View Article and Find Full Text PDFIntertriginous Xanthomas: Clues to Homozygous Familial Hypercholesterolemia.
Indian Dermatol Online J
August 2024
Recalcitrant extensive dermatophytosis in twin brothers with APECED syndrome.
Pediatr Dermatol
September 2024
Article Synopsis
- - Chronic mucocutaneous candidiasis (CMC) involves repeated Candida infections and is often associated with primary immunodeficiencies.
- - A case study of two 8-year-old identical twins reveals they were diagnosed with APECED syndrome after showing symptoms like extensive skin and nail infections, malabsorption, and dental issues due to a mutation in the AIRE gene.
- - This case emphasizes the unusual skin infection presentation in APECED and highlights how clinical symptoms can vary significantly, even among genetically identical siblings.
Radiofrequency-assisted fractional thermolysis for drug delivery in Keloids.
Indian J Dermatol Venereol Leprol
January 2024
A novel indication for non-cultured epidermal suspension: Post-inflammatory depigmentation in atopic dermatitis.
Indian J Dermatol Venereol Leprol
July 2024
A pedunculated nodule on lower lip.
Indian J Dermatol Venereol Leprol
January 2025
Article Synopsis
- STIs are a major global health issue that adversely impacts sexual and reproductive health, especially in low-resource settings due to gaps in evidence and tools.
- In 2022, the WHO launched an initiative to prioritize STI research, identifying 40 key areas, with a focus on developing affordable diagnostic tests, new treatments, and enhanced epidemiologic data.
- The priorities also emphasize innovative approaches to STI communication and partner management, and include research related to mpox, highlighting the need for STI studies during disease outbreaks linked to sexual transmission.
Background Increasing rates of macrolide and fluroquinolone resistance in Mycoplasma genitalium (MG) are being reported worldwide with resultant treatment failure. Aim We aimed to determine the level of antibiotic resistance of MG in men who have sex with men (MSM) attending a sexually transmitted infections (STIs) clinic in New Delhi, India. Methods Real-time polymerase chain reaction (PCR) assays targeting MgPa and pdhD genes were performed to detect MG rectal, urogenital or oropharyngeal infections in 180 MSM between January 2022 and June 2023.
View Article and Find Full Text PDFArticle Synopsis
- - Bacterial vaginosis (BV) is a common vaginal infection linked to an imbalance in vaginal bacteria, which plays a critical role in its onset and persistence.
- - Researchers analyzed vaginal microbiome samples using advanced sequencing techniques to identify differences between healthy and BV-affected individuals, revealing specific anaerobic bacteria associated with biofilm formation.
- - The study suggests potential new treatments for BV, highlighting compounds like Dalfopristin, Clorgyline, and Hydrazine, and offers insights into the underlying mechanisms of the condition.
Article Synopsis
- Scientists have found a new drug called MJ04 that could help with hair loss by blocking a specific part of a pathway in the body.
- This drug has shown great results in tests on mice, making their hair grow back quicker when applied directly to the skin.
- MJ04 is safe to use and works well, making it a good option for future studies in humans to help people with hair loss.