Publications by authors named "Somdatta Roy"
Article Synopsis
- Site-specific delivery of chemotherapeutics to neoplastic hepatocytes (cancerous liver cells) aims to treat hepatocellular carcinoma (HCC) without harming normal liver cells.
- The study investigates a novel drug nanocarrier, PTX-NPL5, which uses the aptamer TLS 9a designed to induce apoptosis (cell death) specifically in cancerous cells, and compares it with other known targeting methods.
- Results showed PTX-NPL5 was the most effective at selectively causing apoptosis in cancer cells while sparing healthy cells, and identified specific proteins that facilitate its targeted delivery, suggesting promise for clinical application in improving HCC treatment.
Aim: Procaine that is able to reach the peripheral nervous system (PNS) was conjugated as a ligand with lipid nanovesicle and loaded with ribavirin (a broad spectrum antiviral drug incapable of entering the PNS on its own) to target the PNS with a dual-drug effect.
Materials & Methods: Different physicochemical characterizations, γ-scintigraphy and electromyography of the developed nanovesicle were conducted.
Results: Marked capability of the optimized radiolabeled formulation to target PNS was observed in rats.