Publications by authors named "Somdatta Das"
Background: Lacunae exist in understanding the underlying etiology in majority of recurrent pregnancy loss (RPL) cases. Given the significance of regulated immune-modulation in pregnancy, and the central role of pro-inflammatory TNF-α plays in it; this study targeted to appraise the significance of TNF-α profile in RPL pathogenesis in an ethnically distinct population from Assam, India.
Methods: Term delivery, medically terminated pregnancy (MTP) and RPL cases (based on ASRM criteria) were enrolled with no anatomical and chromosomal abnormalities or pathological infections; and blood and/or placenta/product of conceptus (POC) tissue samples were collected with informed consent.
Article Synopsis
- This study investigates the role of TNF-α -308G/A genetic variations and TNF-α expression levels in the development of rheumatoid arthritis (RA).
- It involved a case-control design with 126 RA patients and 160 controls, finding increased mRNA and protein levels of TNF-α in RA patients.
- The TNF-α -308A allele was linked to a higher risk of developing RA, suggesting that screening for this variant could be important before starting anti-TNF-α therapy.
Article Synopsis
- Preterm delivery (PTD) is a major cause of neonatal health issues, especially prevalent in Northeast India, making it a significant concern for maternal and infant health.
- The study evaluates the impact of genetic factors, specifically MTHFR gene polymorphism and progesterone receptor (PR) gene mutation (PROGINS), on the risk of PTD, poor pregnancy outcomes, and low birth weight (LBW) among Northeast Indian women.
- Results indicate that both genetic factors increase the likelihood of PTD and negative pregnancy outcomes, with MTHFR C677T polymorphism being particularly predictive and useful for identifying at-risk pregnancies.