Background: Although obesity is considered as the main cause of Type II diabetes (T2DM), non-obese individuals may still develop T2DM and obese individuals may not.
Method: The mRNA expression of axis from 100 non-obese and obese participants with insulin sensitivity and insulin resistance states were compared in this study toward the understanding of obesity heterogeneity molecular mechanism.
Result: In present study, there was no statistically significant difference in gene expression levels of and between groups, whereas , and genes were expressed at a lower level in obese diabetic group compared to other groups and were statistically significant.