The Association of Human Leukocyte Antigen Genotyping Among Sudanese Patients With Rheumatoid Arthritis: Reference to Ethnicity.

Introduction:  Human leukocyte antigens (HLA) account for up to one-half of the total genetic contribution to rheumatoid arthritis (RA) risk. The study investigated the association of HLA class II genotyping with RA susceptibility in Sudanese ethnic groups.

Methods:  The DRB1 and DQB1 alleles and haplotypes were determined in 122 RA patients (i.

Association of Human Leukocyte Antigen (HLA) class II ( and ) alleles and haplotypes with Rheumatoid Arthritis in Sudanese patients.

The aim of this study was to determine the Human Leukocyte Antigen (HLA) class II ( and ) alleles and haplotype frequency in Rheumatoid Arthritis RA) in the Sudanese population. The frequency of and - alleles and haplotypes were determined in 122 RA patients and 100 controls. HLA alleles were genotyped by the polymerase chain reaction-sequence specific primers (PCR-SSP) method.