Publications by authors named "Somak Chaudhuri"
Int Immunopharmacol
September 2023
Article Synopsis
- Interferon-gamma (IFN-γ) is produced mainly by T cells and natural killer cells and leads to increased nitric oxide (NO) production, which is linked to various inflammatory diseases like peritonitis and inflammatory bowel diseases.
- The study screened the LOPAC® library for non-steroidal small molecule inhibitors of IFN-γ-induced NO production, identifying lead compounds such as pentamidine and auranofin, with auranofin showing the strongest inhibition.
- In vivo tests on models of ulcerative colitis and sepsis revealed that pentamidine and auranofin significantly improved survival and protection, highlighting their potential as new anti-inflammatory treatments targeting IF
