Heterochromatin extension: a possible cytogenetic fate of primary amenorrhea along with normal karyotype.

Primary amenorrhoea (PA) is considered to be one of the challenging and taxing problems for the gynaecologist. Previous studies suggested that different numerical and structural chromosome abnormalities are associated with this. Heterochromatin polymorphisms are considered to be normal variant but considering the recent research on crucial cellular effects of heterochromatin, we have aimed to find out the prevalence of heteromorphism along with other standard chromosomal abnormalities.

Bernard-Soulier syndrome (BSS) with uncontrollable menorrhagia.

Menorrhagia is a common problem in women of reproductive age group and 5% of women between 30 and 49 years of age group consult their general practitioner for this problem. Menorrhagia occurring in adolescent age group and perimenopausal age group is chiefly due to anovulatory cycles. In perimenopausal age group, local pathology like leiomyomas can also contribute to menorrhagia.

Analyzing the etiology behind mortality associated with antepartum, intrapartum, and post-partum cases in a tertiary care teaching hospital of West Bengal.

Objective: The study was undertaken to understand the causes and circumstances of maternal deaths in West Bengal.

Material And Methods: One hundred ten maternal deaths were reported during the period December 2010 through June 2012 in the Maternity Ward of Medical College and Hospitals, West Bengal. These deaths were reviewed using a facility-based Maternal Death Review protocol.

Role of Intravenous Tranexamic Acid on Caesarean Blood Loss: A Prospective Randomised Study.

Background: Post-partum haemorrhage (PPH) is a major cause of maternal mortality globally. Tranexamic acid, an anti-fibrinolytic agent, is a novel approach in an attempt to prevent this dreadful complication. This study aims to document the efficacy of intravenous (IV) tranexamic acid in reducing blood loss during and after caesarean section (CS).

Phylogenetic background of E. coli isolated from asymptomatic pregnant women from Kolkata, India.

Introduction: Asymptomatic bacteriuria (ABU) in pregnancy generates medical complications. E. coli is the common etiologic agent responsible for ABU-associated infections.

Did you choose the right suture material for skin closure in elective caesarean section?

Surgical incision should heal with first intension with minimum deformity. Pain perception during postoperative period (short term) and appreciation of scar (long term) are two key components assessed by patients after a caesarean section. The present study compares these parameters using absorbable and non-absorbable material for skin closure using subcuticular stitch.

Hysterectomy…..Which route?

Objective: We designed this study to focus on women with mobile uteri benign no larger than 14 weeks, who would ordinarily be considered candidates for vaginal hysterectomy and compare the outcomes when abdominal routes were chosen. We also compared the intra and post operative complications, requirement for blood transfusion, length of hospital stay, between abdominal and vaginal route of hysterectomy.

Method: In a simple randomized prospective comparative study 200 consecutive patients requiring hysterectomy for benign uterine conditions were analysed over a period of 2 years.

A study evaluating the effect of mifepristone (RU-486) for the treatment of leiomyomata uteri.

Background: To estimate the efficacy of daily administration of 25 mg mifepristone for the treatment of uterine leiomyoma.

Materials And Methods: A total of 30 women were to receive 25 mg mifepristone daily for a period of 6 months. Abdominal ultrasonography was performed before treatment, at 3 months and after 6 months, to evaluate the leiomyoma size and uterine volume.

Detection of cancer cervix by estimation of sialic acid.

The study was undertaken to determine the sialic acid concentration of cervical tissue and serum of women with healthy and unhealthy cervix. The sialic acid value in local tissue of cervix and in serum showed slight elevation in benign inflammatory lesions, moderate elevation was found in severe dysplasia and preinvasive carcinoma and marked elevation in invasive carcinoma cervix. The values, both in the serum and in the cervical tissue, increased gradually with the advancement of grading of frank malignancy.