Quorum sensing inhibitory activity of sub-inhibitory concentrations of β-lactams.

Introduction: The virulence factors of are under the control of quorum sensing (QS) signals. Hence, interference with QS prevents its pathogenesis.

Objective: The aim of the present research is to assess the influence of some β-lactam antibiotics on cell communication and the release of different virulence factors.

Aspirin is an efficient inhibitor of quorum sensing, virulence and toxins in Pseudomonas aeruginosa.

Quorum sensing (QS) plays a vital role in regulation of virulence factors and toxins in Pseudomonas aeruginosa, which can cause serious human infections. Therefore, the QS system in P. aeruginosa may be an important target for pharmacological intervention.