Palladium-Catalyzed -Michael-Type Hydroamination of -(Quinolin-8-yl)acrylamide with 2-Pyridones.

Here we report a palladium-catalyzed -Michael-type hydroamination of -(quinolin-8-yl)acrylamide with 2-pyridones. The use of a palladium catalyst enables the α-addition of 2-pyridones, resulting in the formation of a range of -substituted 2-pyridone carboxamides with yields ranging from 10% to 80%. Derivatization of the products highlights the utility of this transformation.