Publications by authors named "Soma Fukuda"
Objective: Whether metal stents (MS) or plastic stents (PS) yield better outcomes for malignant biliary obstruction in endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is controversial. We aimed to compare outcomes of initial EUS-HGS performed with MS or PS.
Methods: In this single-center retrospective study, we included patients (MS/PS groups: n = 151/72) with unresectable malignant biliary obstruction and performed multivariable analysis.
Article Synopsis
- The study aimed to assess the safety and effectiveness of propofol sedation in complex endoscopic procedures like endoscopic cholangiopancreatography, focusing on risk factors for excessive sedation.
- A review of 870 patient cases highlighted sedation-related issues, revealing rates of excessive sedation (7.8%), hypoxemia (6.0%), and hypotension (1.8%), with obesity and sleep apnea significantly linked to higher sedation risks.
- The findings suggest that sedation strategies for these patients should be personalized, especially for those with identified risk factors such as obesity and prolonged procedure times.
Tissue sampling in biliary tract cancer (BTC) is generally performed through transpapillary biopsy (TPB) or endoscopic ultrasound-guided tissue acquisition (EUS-TA). For the first time, we compared the suitability of specimens obtained using TPB and EUS-TA to determine the optimal tissue-sampling method for comprehensive genome profiling (CGP) analysis in patients with unresectable BTC (UR-BTC). Pathology precheck criteria for CGP analysis comprised the OncoGuide NCC Oncopanel System (NCCOP) and FoundationOne CDx (F1CDx).
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- The PRIMATE study focuses on optimizing tissue collection methods through EUS-guided fine-needle aspiration (EUS-TA) for patients with unresectable pancreatic cancer to improve genomic profiling.
- The study compares success rates of tissue specimens from both primary and metastatic lesions to meet specific analysis criteria established by the OncoGuide NCC Oncopanel.
- Results will be shared in an international conference and peer-reviewed journal, and the study has been approved by the National Cancer Center Institutional Review Board (Research No. 2022-168).
Article Synopsis
- Endoscopic ultrasound-guided hepaticogastrostomy with bridging shows a high technical success rate (90%) and minimal adverse events, making it a viable alternative to traditional drainage methods for malignant hilar biliary obstruction.
- In terms of stent patency, patients receiving this method experienced a significantly lower rate of recurrent biliary obstruction (17.6%) compared to those undergoing endoscopic transpapillary drainage-multi-stenting (58.5%).
- Results indicated that the endoscopic ultrasound-guided hepaticogastrostomy with bridging method provided longer median times to recurrent biliary obstruction, with strong potential for improved long-term outcomes, suggesting a need for further prospective studies.
Article Synopsis
- Endoscopic ultrasound-guided gastroenterostomy is a procedure to connect the stomach with an afferent loop affected by dilation, aimed at treating afferent loop syndrome; the study assesses its effectiveness and safety.
- The research found a 100% technical success rate and a 96% clinical success rate among 25 patients, with some serious early adverse events related to fluid leakage but no late complications.
- The procedure demonstrated a 32% rate of recurrent intestinal obstruction after a median of 6.5 months, but was highly successful in re-interventions, confirming its overall effectiveness and safety for this condition.
Article Synopsis
- Endoscopic ultrasound-guided pancreatic duct drainage (EUS-PD) is becoming a viable alternative for treating obstructive pancreatitis when traditional methods fail, but it has a concerning 20% rate of adverse events.
- A new plastic stent designed for EUS-PD was tested in a study involving 10 patients, where both technical and clinical success rates reached 100%, with only one experiencing a mild adverse event.
- Overall, the findings suggest that this novel stent appears to be a safe and effective option for EUS-PD, with a low recurrence rate of pancreatic duct obstruction.
Endoscopic gastroduodenal stent (GDS) deployment is currently a standard treatment for malignant gastric outlet obstruction (mGOO) in patients with limited life expectancy; however, stent dysfunction (SD) and complicated pancreatitis often occur after GDS deployment. We investigated incidence and contributing factors of SD and complicated pancreatitis. We retrospectively reviewed 203 patients who underwent initial GDS deployment for palliation of mGOO symptoms between October 2017 and July 2022, including 109 who underwent GDS deployment across the duodenal papilla (sub-cohort).
View Article and Find Full Text PDFBackground/aim: Bevacizumab-based chemotherapy is the standard treatment for metastatic colorectal cancer (mCRC) but has several specific adverse events. The cumulative bevacizumab dose (CBD) increases with long-term treatment as it is often used beyond the first disease progression, based on existing evidence. However, the association between CBD and the frequency and severity of adverse events in mCRC patients who received bevacizumab for long-term treatment remains unclear.
View Article and Find Full Text PDFPatients with inflammatory bowel disease (IBD) are more likely to have concurrent immune-mediated inflammatory diseases (IMIDs) than those without IBD. IMIDs have been observed to alter the phenotype and outcomes of IBD in recent studies. Several studies have found that IBD patients with concurrent IMIDs may have more extensive or severe disease phenotypes, and are considered to be at increased risk of requiring biologics and IBD-related surgeries, suggesting that having multiple IMIDs is a poor prognostic factor for IBD.
View Article and Find Full Text PDFVideo 1Endoscopic hemostasis of colonic diverticular bleeding using red dichromatic imaging to identify the bleeding point.
View Article and Find Full Text PDFBackground And Aim: Autoimmune pancreatitis (AIP) and inflammatory bowel disease (IBD) are categorized into immune-mediated inflammatory disorders (IMIDs). While AIP is a pancreato-biliary IMID with an increased incidence and prevalence among patients with IBD, its features are still unclear. This systematic review and meta-analysis aims to assess the prevalence and clinical characteristics of AIP-IBD patients.
View Article and Find Full Text PDFDihydropyrimidine dehydrogenase (DPD) deficiency induces severe adverse events in patients receiving fluoropyrimidines. We encountered a 64-year-old DPD-deficient man with a severe capecitabine-related gastrointestinal disorder. He received capecitabine-containing chemotherapy after rectal cancer resection.
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