Endophytic bacteria Klebsiella spp. and Bacillus spp. from Alternanthera philoxeroides in Madiwala Lake exhibit additive plant growth-promoting and biocontrol activities.

Background: The worldwide increase in human population and environmental damage has put immense pressure on the overall global crop production making it inadequate to feed the entire population. Therefore, the need for sustainable and environment-friendly practices to enhance agricultural productivity is a pressing priority. Endophytic bacteria with plant growth-promoting ability and biocontrol activity can strongly enhance plant growth under changing environmental biotic and abiotic conditions.

Understanding the Role of Antimicrobial Peptides in Neutrophil Extracellular Traps Promoting Autoimmune Disorders.

AMPs are small oligopeptides acting as integral elements of the innate immune system and are of tremendous potential in the medical field owing to their antimicrobial and immunomodulatory activities. They offer a multitude of immunomodulatory properties such as immune cell differentiation, inflammatory responses, cytokine production, and chemoattraction. Aberrancy in neutrophil or epithelial cell-producing AMPs leads to inflammation culminating in various autoimmune responses.

Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice.

Specialized connective tissues, including bone and adipose tissues, control various physiological activities, including mineral and energy homeostasis. However, the identity of stem cells maintaining these tissues throughout adulthood remains elusive. By conducting genetic lineage tracing and cell depletion experiments in newly generated knock-in Cre/CreER lines, we show here that rare Prrx1-expressing cells act as stem cells for bone, white adipose tissue and dermis in adult mice, which are indispensable for the homeostasis and repair of these tissues.

Notch1 signaling in keratocytes maintains corneal transparency by suppressing VEGF expression.

The cornea fends off chemicals, dirt, and infectious particles and provides most of the eye's focusing power. Corneal transparency is of paramount importance to normal vision, yet how it is established and maintained remains unclear. Here, we ablated Notch1 in keratocytes using Twist2-Cre mice and found that Twist2-Cre; Notch1 mice developed stroma expansion and neovascularization, followed by hyperproliferation and metaplasia of corneal epithelial progenitor cells and plaque formation at central cornea, leading to loss of transparency.

Formulation of Water Sustainability Index for India as a performance gauge for realizing the United Nations Sustainable Development Goal 6.

Anthropogenic activities targeting economic progress have triggered changes in the Earth system processes causing depletion of resources and degradation of ecosystems. Water is a critical natural resource which has been severely impacted through groundwater depletion, surface water contamination and ocean acidification resulting in repercussions on human health and biodiversity losses. Likewise, India, a mega biodiversity nation has been critically affected by degradation and drawdown of water resources with far-reaching consequences on environmental vitality and socio-economic development.

Prevalence and Associated Factors of Antenatal Anxiety Symptoms in Bangladesh: A Repeated Measures Cluster Data Analysis.

Background: Antenatal Anxiety affects the mothers and their child. Spontaneous abortion, preeclampsia, preterm birth, and low birth weight are the most common consequences. In Bangladesh, we have very limited understanding about the burden of antenatal anxiety and its associated factors.

Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid.

Disorders of the transparent cornea affect millions of people worldwide. However, how to maintain and/or regenerate this organ remains unclear. Here, we show that (encoding a canonical NF-κB subunit) ablation in K14 corneal epithelial stem cells not only disrupts corneal regeneration but also results in age-dependent epithelial deterioration, which triggers aberrant wound-healing processes including stromal remodeling, neovascularization, epithelial metaplasia, and plaque formation at the central cornea.

mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK.

Renal cell carcinoma (RCC) mainly originates from renal proximal tubules. Intriguingly, disruption of genes frequently mutated in human RCC samples thus far has only generated RCC originated from other renal tubule parts in mouse models. This hampers our understanding of the pathogenesis of RCC.

Elevated HB-EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin/Orexin expression.

Obesity is common in the middle aged population and it increases the risks of diabetes, cardiovascular diseases, certain cancers, and dementia. Yet, its etiology remains incompletely understood. Here, we show that ectopic expression of HB-EGF, an important regulator of neurogenesis, in Nestin neuroepithelial progenitors with the Cre-LoxP system leads to development of spontaneous middle age obesity in male mice accompanied by hyperglycemia and insulin resistance.

Changes in Depressive Symptoms During the Antenatal Period: A Cohort Study from Bangladesh.

Background: Antenatal depressive symptoms adversely affect the health and well-being of women, babies, and their families. This study aimed to explore the prevalence and probable associated factors of depressivse symptoms.

Methods: A prospective cohort approach was adopted, and 435 pregnant women were assessed longitudinally at an antenatal clinic in the first, second, and third trimesters.

The noncanonical BMP signaling pathway plays an important role in club cell regeneration.

The bronchiole is a major site for the development of several life-threatening disorders, including chronic obstructive pulmonary disease and lung adenocarcinomas. The bronchiolar epithelium is composed of club cells and ciliated epithelial cells, with club cells serving as progenitor cells. Presently, the identity of the cells involved in regeneration of bronchiolar epithelium and the underlying mechanisms remain incompletely understood.

Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin.

Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion of , encoding an inhibitor of IHH receptor Smoothened (SMO), in chondrocyte or osteoblasts does not cause tumorigenesis. Here, we show that deletion in mice Prrx1mesenchymal stem/stromal cells (MSCs) promotes MSC proliferation and osteogenic and chondrogenic differentiation but inhibits adipogenic differentiation.

Generalized Zero-Shot Cross-Modal Retrieval.

Cross-modal retrieval is an important research area due to its wide range of applications, and several algorithms have been proposed to address this task. We feel that it is the right time to take a step back and analyze the current status of research in this area. As new object classes are continuously being discovered over time, it is necessary to design algorithms that can generalize to data from previously unseen classes.

Generalized Semantic Preserving Hashing for Cross-Modal Retrieval.

Cross-modal retrieval is gaining importance due to the availability of large amounts of multimedia data. Hashing-based techniques provide an attractive solution to this problem when the data size is large. For cross-modal retrieval, data from the two modalities may be associated with a single label or multiple labels, and in addition, may or may not have a one-to-one correspondence.

Reducing uncertainties in energy dissipation measurements in atomic force spectroscopy of molecular networks and cell-adhesion studies.

Atomic force microscope (AFM) based single molecule force spectroscopy (SMFS) is a valuable tool in biophysics to investigate the ligand-receptor interactions, cell adhesion and cell mechanics. However, the force spectroscopy data analysis needs to be done carefully to extract the required quantitative parameters correctly. Especially the large number of molecules, commonly involved in complex networks formation; leads to very complicated force spectroscopy curves.

BMPRIA is required for osteogenic differentiation and RANKL expression in adult bone marrow mesenchymal stromal cells.

Bone morphogenetic proteins (BMPs) activate the canonical Smad1/5/8 and non-canonical Tak1-MAPK pathways via BMP receptors I and II to regulate skeletal development and bone remodeling. Specific ablation of Bmpr1a in immature osteoblasts, osteoblasts, or osteocytes results in an increase in cancellous bone mass, yet opposite results have been reported regarding the underlying mechanisms. Moreover, the role for BMPRIA-mediated signaling in bone marrow mesenchymal stromal cells (BM-MSCs) has not been explored.

Simultaneous Semi-Coupled Dictionary Learning for Matching in Canonical Space.

Cross-modal recognition and matching with privileged information are important challenging problems in the field of computer vision. The cross-modal scenario deals with matching across different modalities and needs to take care of the large variations present across and within each modality. The privileged information scenario deals with the situation that all the information available during training may not be available during the testing stage, and hence, algorithms need to leverage the extra information from the training stage itself.

Bone Size and Quality Regulation: Concerted Actions of mTOR in Mesenchymal Stromal Cells and Osteoclasts.

The bone size and quality, acquired during adolescent growth under the influence of anabolic hormones, growth factors, and nutrients, determine the height and bone stability and forecast osteoporosis risks in late life. Yet bone size and quality control mechanisms remain enigmatic. To study the roles of mammalian target of rapamycin (mTOR) signaling, sensor of growth factors and nutrients, in bone size and quality regulation, we ablated Tsc1, a suppressor of mTOR, in mesenchymal stromal cells (MSCs), monocytes, or their progenies osteoblasts and osteoclasts.

The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength.

Physical exercise is beneficial to bone health. However, little is known how different intensities of exercise affect bone mass and strength. In the present study, we used young mice to study the effects of different intensities of exercise on bone mass and bone strength in comparison to pharmacological doses of active vitamin D (calcitriol).

Generalized Coupled Dictionary Learning Approach With Applications to Cross-Modal Matching.

Coupled dictionary learning (CDL) has recently emerged as a powerful technique with wide variety of applications ranging from image synthesis to classification tasks. In this paper, we extend the existing CDL approaches in two aspects to make them more suitable for the task of cross-modal matching. Data coming from different modalities may or may not be paired.

Bayesian Modeling of Temporal Coherence in Videos for Entity Discovery and Summarization.

A video is understood by users in terms of entities present in it. Entity Discovery is the task of building appearance model for each entity (e.g.

Low Resolution Face Recognition Across Variations in Pose and Illumination.

We propose a completely automatic approach for recognizing low resolution face images captured in uncontrolled environment. The approach uses multidimensional scaling to learn a common transformation matrix for the entire face which simultaneously transforms the facial features of the low resolution and the high resolution training images such that the distance between them approximates the distance had both the images been captured under the same controlled imaging conditions. Stereo matching cost is used to obtain the similarity of two images in the transformed space.

p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions.

Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are capable of differentiating into osteoblasts, chondrocytes, and adipocytes. Skewed differentiation of BM-MSCs contributes to the pathogenesis of osteoporosis. Yet how BM-MSC lineage commitment is regulated remains unclear.

Pose-robust recognition of low-resolution face images.

Face images captured by surveillance cameras usually have poor resolution in addition to uncontrolled poses and illumination conditions, all of which adversely affect the performance of face matching algorithms. In this paper, we develop a completely automatic, novel approach for matching surveillance quality facial images to high-resolution images in frontal pose, which are often available during enrollment. The proposed approach uses multidimensional scaling to simultaneously transform the features from the poor quality probe images and the high-quality gallery images in such a manner that the distances between them approximate the distances had the probe images been captured in the same conditions as the gallery images.

Tuning the instability in static mode atomic force spectroscopy as obtained in an AFM by applying an electric field between the tip and the substrate.

We have investigated experimentally the role of cantilever instabilities in determination of the static mode force-distance curves in presence of a dc electric field. The electric field has been applied between the tip and the sample in an atomic force microscope working in ultra-high vacuum. We have shown how an electric field modifies the observed force (or cantilever deflection)-vs-distance curves, commonly referred to as the static mode force spectroscopy curves, taken using an atomic force microscope.