Publications by authors named "Solwayo Ngwenya"

Introduction: We implemented two cross-sectional reproductive age mortality surveys in 2007-2008 and 2018-2019 to assess changes in the MMR and causes of death in Zimbabwe. We collected data from health institutions, civil registration and vital statistics, the community, and surveillance. This paper analyses missingness and misclassification of deaths in the two surveys.

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COVID-19 presented countries with unprecedented health policy challenges. For low-income countries in particular, policymakers had to contend with both the direct threats posed by COVID-19 as well as the social, educational, and economic harms associated with lockdown and other infection prevention and control measures. We present a holistic and contextualised case study of the direct and indirect impacts of COVID-19 on women and children, with some assessment of their uneven distribution across socio-economic, age and gender groups.

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Article Synopsis
  • * A retrospective analysis showed that maternal mortality ratio (MMR) at the hospital fell from 655 to 203 maternal deaths per 100,000 live births between 2011 and 2020, with significant decreases in deaths caused by conditions like hypertensive disorders and pregnancy-related infections.
  • * The 69% reduction in MMR was attributed to effective government interventions, such as improved malaria control, adoption of preventive treatment for pregnant women, enhanced staff training, and better clinical leadership.
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Background: Sustainable Development Goal (SDG) 3.1 target is to reduce the global maternal mortality ratio (MMR) to less than 70 maternal deaths per 100 000 live births by 2030. In the Ending Preventable Maternal Mortality strategy, a supplementary target was added, that no country has an MMR above 140 by 2030.

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Article Synopsis
  • The study investigates the prevalence and risk factors for stillbirth among women with severe preeclampsia at Mpilo Central Hospital in Zimbabwe over a three-year period.
  • Women with severe preeclampsia had a stillbirth prevalence of 9.8%, and several risk factors were identified, including unbooked status, high diastolic blood pressure, and antepartum hemorrhage.
  • The findings aim to help clinicians identify at-risk patients and implement strategies to reduce stillbirth rates in this vulnerable population.
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Background: Reducing maternal mortality is a priority of Sustainable Development Goal 3.1 which requires frequent epidemiological analysis of trends and patterns of the causes of maternal deaths. We conducted two reproductive age mortality surveys to analyse the epidemiology of maternal mortality in Zimbabwe and analysed the changes in the causes of deaths between 2007-08 and 2018-19.

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Objective: Globally, preeclampsia is a significant contributor to adverse maternal outcomes. Once women develop eclampsia, they face considerable risks especially in countries with limited resources to deal with such a life-threatening complication. This study was carried out to investigate determinants of eclampsia in pregnant mothers with severe preeclampsia.

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Background: On the 27 of March 2020 the Zimbabwean government declared the Covid-19 pandemic a 'national disaster'. Travel restrictions and emergency regulations have had significant impacts on maternity services, including resource stock-outs, and closure of antenatal clinics during the lockdown period. Estimates of the indirect impact of Covid-19 on maternal and perinatal mortality was expected it to be considerable, but little data was yet available.

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Objectives: Hypertensive disorders of pregnancy are major causes of global maternal and neonatal morbidity and mortality. This study aimed to develop and validate models to predict composite adverse maternal and neonatal outcome in severe preeclampsia in low-resource settings.

Study Design: A retrospective cross-sectional study of women with severe preeclampsia giving birth in a tertiary referral centre in Zimbabwe between 01/01/2014-31/12/2018.

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Objectives: In low resource settings symptoms and signs may be used to identify which women require intervention to mitigate the risks of severe preeclampsia. This study aimed to report the frequency of signs and symptoms in women with severe preeclampsia and to determine their predictive value for adverse maternal and perinatal outcomes.

Study Design: A retrospective cross-sectional study of women with severe preeclampsia from 01/01/2016 to 31/12/2018 at Mpilo Central Hospital, Bulawayo, Zimbabwe.

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Zimbabwe is one of the countries in sub-Saharan Africa disproportionately affected by human immunodeficiency virus. In the "treat all" era, we assessed the gaps in routine viral load (VL) monitoring at six months for children (0-9 years) and adolescents (10-19 years) newly initiated on anti-retroviral therapy (ART) from January 2017 to September 2018 at a large tertiary hospital in Bulawayo. In this cohort study using secondary data, we considered first VL done within six to nine months of starting therapy as 'undergoing VL test at six months'.

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Article Synopsis
  • The study analyzes maternal mortality at Mpilo Central Hospital from 2015 to 2018, focusing on the link between various risk factors and maternal deaths.
  • The dataset includes information from 387 women, with both cases (those who died) and controls (survivors), covering socio-demographic and clinical data.
  • Understanding these risk factors is crucial for reducing maternal mortality, particularly in low-resourced countries where it is a significant issue.
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Objectives: Early-onset severe preeclampsia is associated with significant maternal and perinatal morbidity and mortality especially in low-resource settings, where women have limited access to antenatal care. This dataset was generated from a retrospective cross-sectional study carried out at Mpilo Central Hospital, covering the period February 1, 2016 to July 30, 2018. The aim of the study was to determine the incidence of early-onset severe preeclampsia and eclampsia, and associated risk factors in a low-resource setting.

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Sepsis remains a major cause of maternal deaths globally. It is one of the major causes of maternal morbidity and mortality in women of reproductive age. It is important that such a major contributor is studied in low-resource settings.

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Article Synopsis
  • Hypertensive disorders in pregnancy significantly contribute to maternal and infant health risks, particularly in low-resource environments.
  • Existing risk prediction models show variable effectiveness, indicating a need for improvement, especially since there are none evaluated in Zimbabwe.
  • This study aims to develop and test new statistical models using data from mothers and babies to better identify those at risk, potentially reducing health issues on multiple levels.
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Article Synopsis
  • Severe preeclampsia and eclampsia negatively impact the health of both mothers and newborns, leading to adverse outcomes during pregnancy and delivery.
  • Mothers giving birth at 27-29 weeks of gestation are at a significantly higher risk for adverse maternal outcomes compared to those delivering at 37-39 weeks, with an 8-fold increase in risk.
  • Low platelet counts (0-49 x 10/l) are strongly linked to both negative maternal outcomes (46 times higher risk) and adverse perinatal outcomes (4 times higher risk) compared to normal platelet counts.
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A global concern is to end preventable stillbirths by the year 2030. The objective of this study was to document the stillbirth rate and causes of stillbirths in a low-resource setting. This was a retrospective descriptive study carried out at Mpilo Central Hospital, a tertiary teaching referral government hospital in Bulawayo, Zimbabwe during the period January to December 2016.

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Background: Stillbirths are distressing to the parents and healthcare workers. Globally large numbers of babies are stillborn. A number of strategies have been implemented to try and reduce stillbirths worldwide.

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Background: Severe preeclampsia is a disorder of pregnancy characterized by high blood pressure and significant proteinuria after 20 weeks gestation. Severe preeclampsia and eclampsia have considerable adverse impacts on maternal, fetal, and neonatal health especially in low-resource countries. Hypertensive disorders of pregnancy are the third leading cause of maternal deaths in Sub-Saharan Africa.

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Background Ectopic pregnancy contributes to maternal morbidity and mortality, especially in low-resourced countries with limited facilities for early diagnosis and treatment. It is a very challenging condition to diagnose. Patients may collapse and die while undergoing investigation.

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Background: Primary postpartum hemorrhage (PPH) is defined as blood loss from the genital tract of 500 mL or more following a normal vaginal delivery (NVD) or 1,000 mL or more following a cesarean section within 24 hours of birth. PPH contributes significantly to maternal morbidity and mortality worldwide. Women can rapidly hemorrhage and die soon after giving birth.

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Introduction: The complications of HIV/AIDS can produce grossly abnormal pathology. In low-resourced settings, women can present late with huge lesions. Massive vulval pathology copresenting in pregnancy produces difficulties in managing the patients and may lead to poor maternal or fetal outcomes.

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A 32 year-old P G was referred from a rural hospital for fibroids in pregnancy. The pregnancy test was positive. An ultrasound scan reported a huge left extrauterine mass.

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Problem: In Zimbabwe, many health facilities are not able to manage serious obstetric complications. Staff most commonly identified inadequate training as the greatest barrier to preventing avoidable maternal deaths.

Approach: We established an onsite obstetric emergencies training programme for maternity staff in the Mpilo Central Hospital.

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Background: We report an extremely rare case of massive hemoptysis and complete left-sided lung collapse in pregnancy due to pulmonary tuberculosis in a health care worker with good maternal and fetal outcome.

Case Presentation: A 33-year-old human immuno deficiency virus seronegative African health care worker in her fourth pregnancy with two previous second trimester miscarriages and an apparently healthy daughter from her third pregnancy presented coughing up copious amounts of blood at 18 weeks and two days of gestation. She had a cervical suture in situ for presumed cervical weakness.

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