Association of the C3953T (rs1143634) variant of the interleukin 1 beta gene with the features of a complicated course of COVID-19-associated pneumonia.

Background: The pro-inflammatory cytokine IL-1 plays an important role in severe COVID-19. A change in IL-1 production may be associated with a mutation in the IL1Β gene. Our study analyzed the impact of the IL1Β gene variants (rs1143634) on disease progression in patients with severe COVID-19 pneumonia, taking into account treatment strategies.

[Predicting the occurrence of severe intraventricular hemorrhages and ways to prevent their development in preterm infants].

Objective: Introduction: Severe intraventricular hemorrhages (IVH) in preterm infants are one of the major public health problems, as they can cause neurological and cognitive impairment, as well as lethal outcomes. The aim: To prevent the development of IVH in preterm infants by developing an algorithm for identification of high risk infants and a bundle for the prediction and prevention of this pathology.

Patients And Methods: Materials and methods: A multicenter study (2013-2016) was conducted, which included 117 premature babies who were on treatment in 4 medical institutions in the Poltava region (Ukraine).

[Psychological status of patients with different clinical variants of irritable bowel syndrome].

In the study of psychological status of patients with different clinical variants of irritable bowel syndrome we found each variant to be characterized by worry, but the anxiety is typical only of IBS with diarrhea, while depression is typical of IBS with constipation in contrast to other IBS variants (nonspecific IBS and mixed IBS ones).

[Disturbances of gastrointestinal motility of the stomach in patients with chronic gastric erosions and biliary tract disease].

Article dwells on comparison data about motor function of the stomach in the three groups of patients: with gastric erosions and biliary tract diseases, duodenal ulcer disease, chronic gastritis. It is shown, that patients with gastric erosions and biliary tract diseases are characterized by slower evacuation function of the stomach, hypotonus of the stomach. Frequency of duodenal reflux in this group of patients is very high (85,9 %).

[Endoscopical features of precancer changes of the stomach in patients with chronic gastric erosions and biliary tract disease].

Frequency of the precancer changes of the stomach, diagnosed by using zoom-endoscopy, NBI, chromoscopy, in the three groups of patients: with gastric erosions and biliary tract diseases, with gastric erosions and duodenal ulcer disease, with gastric erosions and chronic gastritis is compared in the article. It is shown, that patients with gastric erosions and biliary tract diseases are characterized by bigger spreading of precancer changes: atrophy, intestinal metaplasia with predominant smalluently intestine in gastric body, intestine metaplasia in antral part of the stomach is revealed more freq in these category of patients. A strong correlation between endoscopical and morphological methods of investigation was demonstrated.

[Characteristics of Helicobacter pylori infection, presence of gastroduodenal and gastroesophageal reflux in patients with erosive gastritis].

A total of 32 patients with chronic antral gastritis without erosion were examined together with 25 patients with chronic erosive antral gastritis. The conclusion reached was that in the above conditions, one could see different strains of Helicobacter pylori. In chronic erosive antral gastritis vs erosion-free chronic antral gastritis H.

[The assessment of the degree of the colonization of the gastric mucosa by Helicobacter pylori and of the gastritis and duodenitis activity in duodenal peptic ulcer in different age groups].

The article contains intriguing data on the difference in H. pylori extents of growth in the gastric antrum mucosa of patients at various ages with duodenal ulcer (DU). A comparative evaluation was done of extents of growth, average antibody titre, and activity of gastritis of the body of antral gastritis and duodenitis in different age groups in DU.