Publications by authors named "Solomon Tsegaye"
This paper presents analyses of anthropometric measurements of Ethiopian young men aged 18-30 years and draws implications for the improvement of the fit of readymade clothing. Thirty-five anthropometric dimensions of 4022 subjects were measured according to ISO 8559:2017. The anthropometric dimensions were described with mean, standard deviation, and some percentiles.
View Article and Find Full Text PDFThe main objective of structural biology is to model proteins and other biological macromolecules and link the structural information to function and dynamics. The biological functions of protein molecules and nucleic acids are inherently dependent on their conformational dynamics. Imaging of individual molecules and their dynamic characteristics is an ample source of knowledge that brings new insights about mechanisms of action.
View Article and Find Full Text PDFArticle Synopsis
- In Ethiopia, breast cancer patients are diagnosed at a younger age and at later stages compared to patients in Europe and the US, leading to a worse prognosis.
- A significant number of Ethiopian patients have hormone-positive breast cancer, contrasting with patterns seen in African Americans, who often have triple-negative breast cancer.
- Genetic analysis of Ethiopian breast tumors revealed more shared mutations with white patients than with African Americans, suggesting the need for targeted research on specific mutations that could lead to new treatment strategies for Ethiopian breast cancer patients.
Cysteine Cathepsins and Matrix Metalloproteases Among Breast Cancer Patients.
Breast Cancer (Dove Med Press)
May 2021
Background: Cellular proteases are thought to increase the likelihood of cancer cell infiltration and metastasis by degrading constituents of the extracellular matrix (ECM). Measuring activities of these proteases may be used as tumor markers for early diagnosis, prognosis, and as a possible target for treatment plan.
Objective: The aim of the current study is to evaluate cysteine cathepsins (CTSK and CTSL) and matrix metalloproteases-2 (MMP-2) and 9 (MMP-9) activities in human breast tumor tissue.
Up to 10% of systemic lupus erythematosus (SLE) cases are drug-induced; hence, they are called drug-induced lupus syndrome (DILS). Antinuclear antibody (ANA) should be present to diagnose SLE and DILS. ANA-negative lupus is very rare; therefore, it presents a diagnostic challenge.
View Article and Find Full Text PDFMaraviroc (MVC) is a potent CCR5 coreceptor antagonist that is in clinical testing for daily oral pre-exposure prophylaxis (PrEP) for HIV prevention. We used a macaque model consisting of weekly SHIV162p3 exposures to evaluate the efficacy of oral MVC in preventing rectal SHIV transmission. MVC dosing was informed by the pharmacokinetic profile seen in blood and rectal tissues and consisted of a human-equivalent dose given 24 h before virus exposure, followed by a booster postexposure dose.
View Article and Find Full Text PDFBackground: Platelets, anucleate cell fragments abundant in human blood, can capture HIV-1 and platelet counts have been associated with viral load and disease progression. However, the impact of platelets on HIV-1 infection of T cells is unclear.
Results: We found that platelets suppress HIV-1 spread in co-cultured T cells in a concentration-dependent manner.