Publications by authors named "Sollini M"
To evaluate neurogenic bladder and bowel dysfunction (NBBD) in children with cerebral palsy (CP) and acquired brain injury (ABI), a condition considered less frequent in those patients than in children with spinal cord injury (SCI), and to study the relationship between NBBD and disability grade in this population. We retrospectively reviewed the clinical data of all patients (aged 3-18 years old) admitted during a three-month observation in our neurorehabilitation department. Data collected were as follows: demographic parameters; disability status (Wee-FIM Scale, Gross Motor Function Classification System (GMFCS) and the Communication Function Classification System); and gastrointestinal and urological symptoms (diaries, Bristol scale, Pad Test and International Consultation on Incontinence Modular Questionnaire).
View Article and Find Full Text PDFArticle Synopsis
- SUVmax is a commonly used but limited parameter in assessing malignant lung nodules, with other metrics like lean body mass-adjusted values potentially offering more reliability.
- A study of 567 patients with suspected lung tumors showed that 91% had primary lung tumors, predominantly adenocarcinomas, yet SUVmax struggled to differentiate between benign and malignant lesions effectively.
- Survival analysis indicated that while SUVmax correlated with factors like overall survival and tumor characteristics, it lacked independent prognostic value, raising doubts about its sole reliance in clinical settings.
Expert consensus on workflow of PET/CT with long axial field-of-view.
Eur J Nucl Med Mol Imaging
February 2025
Purpose: Positron emission tomography/computed tomography (PET/CT) imaging has been widely used in clinical practice. Long axial field-of-view (LAFOV) systems have enhanced clinical practice by leveraging their technological advantages and have emerged as the new state-of-the-art PET imaging modalities. A consensus was conducted to explore expert views in this emerging field to comprehensively elucidate the proposed workflow in LAFOV PET/CT examinations and highlight the potential challenges inherent in the workflow.
View Article and Find Full Text PDFBackground: Recently, radiomics has emerged as a possible image-derived biomarker, predominantly stemming from retrospective analyses. We aimed to prospectively assess the predictive role of [F]FDG-PET radiomics in breast cancer (BC).
Methods: Patients affected by stage I-III BC eligible for neoadjuvant chemotherapy (NAC) staged with [F]FDG-PET/CT were prospectively enrolled.
Background And Objective: This review aims to provide an overview of novel diagnostic and therapeutic radiopharmaceuticals tested recently or used currently in genitourinary cancers within prospective phase 1-2 clinical trials, summarizing progresses and future directions.
Methods: A systematic search was conducted using the PubMed/MEDLINE and ClinicalTrials.gov databases for original prospective research studies following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.
Article Synopsis
- Disease recurrence and resistance to radioiodine therapy pose significant challenges in managing differentiated thyroid cancer, particularly in patients with the TENIS syndrome, characterized by elevated thyroglobulin levels but negative radioiodine scans.
- A systematic review and meta-analysis evaluated the effectiveness of nuclear imaging, specifically [F]FDG PET/CT, on detecting thyroid cancer recurrence in TENIS patients, finding that it has a sensitivity of 87% and specificity of 76%.
- The study highlights the importance of [F]FDG PET/CT in guiding treatment decisions, especially as new radiopharmaceuticals continue to emerge for better detection of RAI-refractory cancer.
Article Synopsis
- Researchers did a review to update how good different types of PET scans are for finding and checking solid cancers (not brain cancers) using special medicines.
- They looked through many studies and found 64 helpful articles that show which types of PET scans work best for various cancers, like prostate and neuroendocrine tumors.
- The review found that some cancers, like esophageal cancer and certain types of lung cancer, don't have enough strong studies to help with diagnosis using PET scans.
Background: For many tumors, radiomics provided a relevant prognostic contribution. This study tested whether the computed tomography (CT)-based textural features of intrahepatic cholangiocarcinoma (ICC) and peritumoral tissue improve the prediction of survival after resection compared with the standard clinical indices.
Methods: All consecutive patients affected by ICC who underwent hepatectomy at six high-volume centers (2009-2019) were considered for the study.
Background: Multiple sclerosis (MS) is increasing in the pediatric population and, as in adults, symptoms vary among patients. In children the first manifestations can sometimes overlap with acute neurological symptoms. Urological symptoms have not been much studied in childhood.
View Article and Find Full Text PDFPurpose: Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is a well described clinical condition, but reports are focused on microcolon and intestinal hypoperistalsis, while data on bladder management are scant. Aim of the study is to present urological concerns in MMIHS.
Methods: Retrospective evaluation of clinical data on urological management of MMIHS patients treated in the last 10 years.
Article Synopsis
- Surgery is the main treatment for patients with low-grade gliomas who have epilepsy, but it's hard to do both well.
- A new imaging technique called MET PET helps doctors see how the tumor acts and plan surgeries better, but it doesn't fully explain how it affects seizures.
- This study looked at 52 patients with brain tumors to see if MET PET could help understand their seizures before surgery and how well those seizures are controlled afterward.
From pixels to predictions: the scrying power of molecular imaging.
Eur J Nucl Med Mol Imaging
February 2024
Medical imaging represents the primary tool for investigating and monitoring several diseases, including cancer. The advances in quantitative image analysis have developed towards the extraction of biomarkers able to support clinical decisions. To produce robust results, multi-center studies are often set up.
View Article and Find Full Text PDFReliable biomarkers for early identification of treatment failure in relapsed/refractory (r/r) classical Hodgkin lymphoma (cHL) are lacking. Circulating tumour DNA (ctDNA) profiling has emerged as a powerful predictive and prognostic tool in several haemopoietic and non-haemopoietic malignancies and may guide rational treatment choices in r/r cHL. To assess the predictive and prognostic value of ctDNA, we performed a retrospective analysis on 55 r/r cHL patients treated with the bendamustine, gemcitabine and vinorelbine (BEGEV) regimen and additionally evaluated the potential utility of integrating ctDNA with interim [ F]-FDG positron emission tomography (iPET).
View Article and Find Full Text PDFThe potential role of osteoporosis in unspecific [F]PSMA-1007 bone uptake.
Eur J Nucl Med Mol Imaging
December 2023
Aim: Unspecific bone uptake is one of the main limitations of PET imaging with some PSMA-targeting radiopharmaceuticals, especially with [F]PSMA-1007. We explored the potential association between osteoporosis and the occurrence of unspecific [F]PSMA-1007 bone uptake investigating markers which might correlate with bone mineral density.
Materials And Methods: We retrospectively analyzed treatment-naïve patients with a confirmed diagnosis of prostate adenocarcinoma who underwent staging [F]PSMA-1007 positron emission tomography (PET).
Purpose: IDH-wildtype (IDH-wt) diffuse gliomas with histological features of lower-grade gliomas (LGGs) are rare and heterogeneous primary brain tumours. [C]Methionine (MET) positron emission tomography (PET) is commonly used to evaluate glial neoplasms at diagnosis. The present study aimed to assess the prognostic value of MET PET in newly diagnosed, treatment naïve IDH-wt gliomas with histological features of LGGs.
View Article and Find Full Text PDFStandard imaging cannot assess the pathology details of intrahepatic cholangiocarcinoma (ICC). We investigated whether CT-based radiomics may improve the prediction of tumor characteristics. All consecutive patients undergoing liver resection for ICC (2009-2019) in six high-volume centers were evaluated for inclusion.
View Article and Find Full Text PDFThis study aimed to examine brain metabolic patterns on [F]Fluorodeoxyglucose ([F]FDG) positron emission tomography (PET) in breast cancer (BC), comparing patients with tension-type headache (TTH), migraine (MiG), and those without headache. Further association with BC response to neoadjuvant chemotherapy (NAC) was explored. In this prospective study, BC patients eligible for NAC performed total-body [F]FDG PET/CT with a dedicated brain scan.
View Article and Find Full Text PDFPerceived risk and decision-making: navigating uncertainty in clinical practice.
Eur J Nucl Med Mol Imaging
January 2024
Purpose: Urological management of Cloacal Malformation (CM) focuses on preserving renal function and continence. Study aim was to analyze urinary and intestinal outcomes in CM patients, considering the length of common channel (CC) and presence of occult spinal dysraphism (OSD).
Methods: Retrospective review of CM treated at our institution by a multidisciplinary team from 1999 to 2020.
Background: Intraoperative localisation of nodal disease in non-small cell lung cancer (NSCLC) can be challenging. Lymph node localisation via radiopharmaceuticals is used in many conditions; we tested the feasibility of this approach in NSCLC.
Methods: NSCLC patients were prospectively recruited.
Article Synopsis
- - Anorectal malformation (ARM) often coexists with congenital issues and requires specialized management; this study focuses on ARM patients with hypospadias and occult spinal dysraphism (OSD) from 1999 to 2022.
- - Out of 222 male ARM patients, 22 (10%) had hypospadias, with evaluations showing that 55% of these hypospadias patients also had OSD, which can complicate treatment plans.
- - Surgical approaches varied: all proximal hypospadias required two surgeries, while distal cases had less consistency in repair rates, highlighting the relationship between ARM, hypospadias management, and the need for neuro-urological assessments.
Background: Ultrasensitive imaging has been demonstrated to influence biochemical relapse treatment. PSICHE is a multicentric prospective study, aimed at exploring detection rate with 68Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) and outcomes with a predefined treatment algorithm tailored to the imaging.
Methods: Patients affected by biochemical recurrence after surgery (prostate specific antigen [PSA] > 0.