Neural in-memory checksums: an error detection and correction technique for safe in-memory inference.

The advent of in-memory computing has introduced a new paradigm of computation, which offers significant improvements in terms of latency and power consumption for emerging embedded AI accelerators. Nevertheless, the effect of the hardware variations and non-idealities of the emerging memory technologies may significantly compromise the accuracy of inferred neural networks and result in malfunctions in safety-critical applications. This article addresses the issue from three different perspectives.

Physicochemical and sensory characterization of functional synbiotic Labneh fortified with the bacteriocin-producing Lactiplantibacillus plantarum strain GA7 and nano-encapsulated Tirmania pinoyi extract.

Background: Functional foods and dairy products are gaining global attention due to their nutritional value and health-promoting characteristics. Lactic acid bacteria (LAB) are one of the promising components included in these products, thanks to their probiotic properties and ability to produce bioactive compounds such as bacteriocins. On the other hand, ectomycorrhizal wild mushrooms (truffles) are known for their ethnomycological importance.

Validation of mitochondrial FMN as a predictor for early allograft dysfunction and patient survival measured during hypothermic oxygenated perfusion.

Hypothermic oxygenated machine perfusion (HOPE) preconditions liver grafts before transplantation. While beneficial effects on patient outcomes were demonstrated, biomarkers for viability assessment during HOPE are scarce and lack validation. This study aims to validate the predictive potential of perfusate flavin mononucleotide (FMN) during HOPE to enable the implementation of FMN-based assessment into clinical routine and to identify safe organ acceptance thresholds.

Debonding Characteristic and Survival Probability of Adhesive Flash-Free Ceramic Orthodontic Brackets Following pH Cycling.

Objectives:  Orthodontic bracket bond failure is an obstacle in clinical orthodontics. This study investigated the influence of pH cycling on the shear bond strength (SBS), adhesive remnant index (ARI), and survival probability of adhesive-precoated flash-free ceramic brackets.

Materials And Methods:  Forty mandibular premolars were randomly divided into two groups ( = 20): C: noncoated orthodontic brackets, and F: flash-free adhesive-precoated orthodontic brackets.

Lipopeptides from Bacillus atrophaeus MCM61 and melatonin suppress gray mold-induced oxidative stress in cut roses (Rosa hybrida L.) and improve vase life.

Application of melatonin and lipopeptides (LPs) derived from Bacillus strains is considered an efficient strategy to control plant diseases at both pre and postharvest stages. However, the combined application of melatonin and LPs has not been studied yet. Therefore, the present study presents the synergistic effect of melatonin and LPs produced by Bacillus atrophaeus strain MCM61 against gray mold disease and its impact on quality parameters and vase life of cut roses.

A one health roadmap towards understanding and mitigating emerging Fungal Antimicrobial Resistance: fAMR.

The emergence of fungal antimicrobial resistance-fAMR-is having a growing impact on human and animal health, and food security. This roadmap charts inter-related actions that will enhance our ability to mitigate the risk of fAMR. As humanity's reliance on antifungal chemicals escalates, our understanding of their one-health consequences needs to scale accordingly if we are to protect our ability to manage the global spectrum of fungal disease sustainably.

Dual hypothermic oxygenated machine perfusion of the liver reduces post-transplant biliary complications: a retrospective cohort study.

Background: Corroborating evidence for the use of hypothermic oxygenated machine perfusion (HOPE) prior to orthotopic liver transplantation (OLT) suggests a beneficial effect in regard to biliary complications. Here, the authors aim to evaluate whether perfusion via portal vein alone (sHOPE) or via additional perfusion of the hepatic artery (dHOPE) have diverging impact on outcomes after OLT when compared to the use of static cold storage (SCS).

Methods: Consecutive patients undergoing OLT at the Medical University of Vienna (2018-2023) were retrospectively analyzed.

Immunosuppressive Induction Therapy Using the Antithymocyteglobulin Grafalon: A Single-Center Non-Interventional Study.

Induction therapy with depleting antibodies in the setting of liver transplantation (LT) is discussed controversially to this day. The rabbit antithymocyteglobulin (ATG) Thymoglobulin (rATG) was introduced as early as 1984 and was frequently used as a standard regime for induction therapy after LT. There are no public reports characterizing Grafalon (ATG-F), a novel ATG, as an induction agent after LT.

Characterization of C-phycocyanin antioxidant, anti-inflammatory, anti-tumour, and anti-HCoV-229E activities and encapsulation for implementation in an innovative functional yogurt.

Functional bioactive ingredients isolated from microalgae as sustainable sources have become a new subject of pharmacology and functional foods. Thus, the work aims to produce crude phycocyanin (C-PC), define it, and investigate its pharmacological effects before warping it in a nanophytosome. Subsequently, the physicochemical properties of nanoparticles were evaluated.

Preclinical development of EXT608, an investigational parathyroid hormone derivative with extended half-life for the treatment of hypoparathyroidism.

Hypoparathyroidism, a deficiency of parathyroid hormone (PTH), results in hypocalcemia, hyperphosphatemia, and hypercalciuria. The disease is poorly controlled by calcium and vitamin D supplements or native PTH(1-84) replacement therapy. A version of PTH is being developed using D-VITylation technology, whereby vitamin D is conjugated to a therapeutic peptide, which confers a long plasma half-life by virtue of binding to the abundant vitamin D binding protein (DBP).

Financial impacts of a housing order on commercial free range egg layers in response to highly pathogenic avian influenza.

Recent annual outbreaks of Highly Pathogenic Avian Influenza (HPAI) have led to mandatory housing orders on commercial free-range flocks. Indefinite periods of housing, after poultry have had access to range, could have production and financial consequences for free range egg producers. The impact of these housing orders on the performance of commercial flocks is seldom explored at a business level, predominantly due to the paucity of commercially sensitive data.

Preparation and characterization of vitamin E/calcium/soy protein isolate nanoparticles for soybean milk beverage fortification.

Soybean milk is a rich plant-based source of protein, and phenolic compounds. This study compared the nutritional value of soybean milk, flour, soy protein isolate (SPI) and evaluated the impact of prepared vitamin E/calcium salt/soy protein isolate nanoparticles (ECSPI-NPs) on fortification of developed soybean milk formulations. Results indicated that soybean flour protein content was 40.

PLM-GAN: A Large-Scale Protein Loop Modeling Using pix2pix GAN.

Revealing the tertiary structure of proteins holds huge significance as it unveils their vital properties and functions. These intricate three-dimensional configurations comprise diverse interactions including ionic, hydrophobic, and disulfide forces. In certain instances, these structures exhibit missing regions, necessitating the reconstruction of specific segments, thereby resulting in challenges in protein design, which encompasses loop modeling, circular permutation, and interface prediction.

Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications.

DNA Topoisomerase IIA (Topo IIA) is an enzyme that alters the topological state of DNA and is essential for the separation of replicated sister chromatids and the integrity of cell division. Topo IIA dysfunction activates cell cycle checkpoints, resulting in arrest in either the G2-phase or metaphase of mitosis, ultimately triggering the abscission checkpoint if non-disjunction persists. These events, which directly or indirectly monitor the activity of Topo IIA, have become of major interest as many cancers have deficiencies in Topoisomerase checkpoints, leading to genome instability.

First demonstration of in-memory computing crossbar using multi-level Cell FeFET.

Advancements in AI led to the emergence of in-memory-computing architectures as a promising solution for the associated computing and memory challenges. This study introduces a novel in-memory-computing (IMC) crossbar macro utilizing a multi-level ferroelectric field-effect transistor (FeFET) cell for multi-bit multiply and accumulate (MAC) operations. The proposed 1FeFET-1R cell design stores multi-bit information while minimizing device variability effects on accuracy.

The hidden carbon impact of animal disease.

Livestock production is under scrutiny for its impact on greenhouse gas (GHG) emissions. Animal disease outbreaks will have economic effects on producers and the indirect cost of an animal disease outbreak is the result of shifts in consumption across commodities. This shift in demand for meat products will also positively or negatively affect carbon emissions.

Effect of Surface Treatments on Adhesion of Milled Polyetheretherketone Post to Different Composite Resin Core Build-Up Materials.

Background: To evaluate the effect of surface treatments on adhesion of milled PEEK post to two different composite resin core-build up materials.

Material And Methods: Six PEEK posts were divided into the following groups: G1: no treatment+ Grandio core material, G2: no treatment+ Bulk-fill core material, G3: 98% sulfuric acid for 60 seconds+ Grandio core material, G4: 98% sulfuric acid for 60 seconds+ Bulk-fill core material, G5: 50 μm airborne particle abraded + Grandio core material, G6: 50 μm airborne particle abraded + bulk fill core material. The adhesion of the post to core build-up materials was tested using micro push-out bond strength.

Impact of Mn-Ni spinal ferrite nanoparticles on the structural, morphological, surface roughness, and optical parameters of polyvinyl alcohol for optoelectronic applications.

Herein, polyvinyl alcohol (PVA) acts as a host matrix for manganese-nickel ferrite (MnNiFeO) nanoparticles (NPs). Oxalate precursors and a solution-cast method were used to produce a MnNiFeO spinel structure and PVA-MnNiFeO films, respectively. X-ray diffraction (XRD), scanning electron microscopy, optical microscopy (OM), a surface roughness tester, and FT-IR spectroscopy were used to identify the structure and morphology of the PVA-MnNiFeO films.

MELD-Na Alterations on the Liver Transplant Waiting List and Their Impact on Listing Outcome.

Background: Dynamic MELD deterioration (Delta MELD) during waiting time was shown to have significant impact on post-transplant survival. The aim of this study was to analyze the impact of MELD-Na score alterations on waiting list outcomes in liver transplant candidates.

Method: 36,806 patients listed at UNOS for liver transplantation in 2011-2015 were analyzed according to their delisting reasons.

Ethylene controls cambium stem cell activity via promoting local auxin biosynthesis.

The vascular cambium is the main secondary meristem in plants that produces secondary phloem (outside) and xylem (inside) on opposing sides of the cambium. The phytohormone ethylene has been implicated in vascular cambium activity, but the regulatory network underlying ethylene-mediated cambial activity remains to be elucidated. Here, we found that PETAL MOVEMENT-RELATED PROTEIN1 (RhPMP1), an ethylene-inducible HOMEODOMAIN-LEUCINE ZIPPER I transcription factor in woody plant rose (Rosa hybrida), regulates local auxin biosynthesis and auxin transport to maintain cambial activity.

Bonding durability and remineralizing efficiency of orthodontic adhesive containing titanium tetrafluoride: an invitro study.

Background: Titanium tetrafluoride has been shown to protect tooth enamel from demineralization. This study investigated the effect of incorporating different concentrations of TiF4 (1, 2 and 3 Wt.%) into an orthodontic primer on the shear bond strength of orthodontic brackets and the enamel microhardness after cariogenic challenges.

Influence of surface treatment on repair bond strength of CAD/CAM long-term provisional restorative materials: an in vitro study.

Background: The surface treatment to improve the repair bond strength may vary because CAD/CAM provisional restoration polymers exhibit a variety of microstructures. This study was conducted to evaluate the effect of surface treatments on the repairability of three different CAD/CAM polymers for long-term provisional restorations.

Methods: Thirty specimens from each provisional restorative materials (CAD-Temp, Everest C-Temp, and PEEK) were divided into three groups: C: surfaces received no treatment; SB: surfaces were airborne particle abraded with 50 μm aluminum oxide; SB-T: surfaces received the same conditions as group SB in addition to thermocycling before and after treatment.

A Multi-Centre Non-Interventional Study to Assess the Tolerability and Effectiveness of Extended-Release Tacrolimus (LCPT) in De Novo Liver Transplant Patients.

Background: Available tacrolimus formulations exhibit substantial inter- and intra-individual variability in absorption and metabolism. The present non-interventional cohort study aimed to assess the tolerability and effectiveness of the once-daily tacrolimus formulation, LCPT, in hepatic allograft recipients in real life.

Materials And Methods: This study was conducted in Austria and the Czech Republic between July 2016 and August 2019.

Screening of antimicrobial and insecticidal properties of essential oils extracted from three Tunisian aromatic and medicinal plants.

The essential oils (EOs) of , and have been screened for their insecticidal activity against , and and for their antimicrobial activity against Gram (+), Gram (-) bacteria and against yeast strain. EO showed good insecticidal activity with 24-h against (LC = 29.7) and against (66.