Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis.

Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million deaths in 2020. In addition, the emergence of drug-resistant strains in many regions of the world threatens national TB control programs.

Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases.

Introduction: Statins, also known as 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, are lipid-lowering agents that are central in preventing or reducing the complications of atherosclerotic cardiovascular disease. Because statins have anti-inflammatory properties, there is considerable interest in their therapeutic potential in other chronic inflammatory conditions. We aim to identify the statin with the greatest ability to reduce systemic inflammation, independent of the underlying disease entity.

Epitope-Based Peptide Vaccine Against Fructose-Bisphosphate Aldolase of Using Immunoinformatics Approaches.

Background: Mycetoma is a distinct body tissue destructive and neglected tropical disease. It is endemic in many tropical and subtropical countries. Mycetoma is caused by bacterial infections () such as and Nocardiae or true fungi () such as .

Phenotypic and Genotypic Analysis of Multidrug-Resistant Isolates from Sudanese Patients.

Currently, mutations in , , and genes and promoter were considered to be involved in conferring resistance to rifampicin, isoniazid, and streptomycin in (MTB). The aims of this study were to detect the prevalence of first-line tuberculosis (TB) drug resistance among a group of previously treated and newly detected TB patients, to determine the association between prevalence of multidrug resistance (MDR) and demographic information (age and sex), to explain genes correlated with MDR , and to characterize MTB via 16S ribosomal RNA (16S rRNA) analysis. A hundred MTB isolates from Sudanese pulmonary TB patients were included in the study.