Deficiency of miR-409-3p improves myocardial neovascularization and function through modulation of DNAJB9/p38 MAPK signaling.

Angiogenesis is critical for tissue repair following myocardial infarction (MI), which is exacerbated under insulin resistance or diabetes. MicroRNAs are regulators of angiogenesis. We examined the metabolic regulation of miR-409-3p in post-infarct angiogenesis.

A restrictive policy for red blood cell transfusion in older hip fracture patients: experiences from a patient register.

Background: Allogeneic red blood cell transfusions (ABT) are common in older hip fracture patients. Recent research supports a restrictive transfusion policy. The aim was to study variation in hemoglobin (Hb) concentration, and clinical outcomes in these patients.

Use of warfarin is associated with delay in surgery for hip fracture in older patients.

Introduction: Delay in surgery for hip fractures in older patients may affect mortality and the risk of delirium. Delay in surgery may occur as a result of several factors. It has not been established whether certain patient-related factors, such as a high international normalized ratio (INR) caused by warfarin treatment is associated with delay in surgery.

Predictors of mortality in older hip fracture inpatients admitted to an orthogeriatric unit in oslo, norway.

Objectives: To identify to which degree patient-related factors (age, gender, place of residence, general health condition, comorbidity) and hospital-related factors (waiting time for surgery, type of surgery, in-hospital complications, length of stay) may predict 1-year mortality in elderly hip fracture patients in an orthogeriatric unit, to optimize treatment and care.

Method: In-hospital patient information was routinely collected by multidisciplinary staff and entered into a database. Information about mortality was obtained for 567 patients aged 65 and above.

Older hip fracture patients: three groups with different needs.

Background: Norway, and particularly Oslo, has the highest reported incidence of hip fractures in the world. It is increasingly common to care for older hip fracture patients in orthogeriatric units where orthopaedic care is combined with interdisciplinary geriatric care. The characteristics and needs of older hip fracture patients are poorly described.

The influence of liposomal formulation factors on the interactions between liposomes and hydroxyapatite.

Liposomes may have potentials as a drug delivery system in the oral cavity; hence, the adsorption to, oral tissues may be of importance. The aim of this study was to find an optimal liposomal formulation with appropriate in vitro stability and which liposomal formulation parameters may be of importance for the interaction to tooth enamel surfaces. Charged liposomes were adsorbed in vitro onto hydroxyapatite (HA), used as a model substance for human dental enamel.

[Antidote availability in Norway].

Background: Antidotes are therapeutic substances that are used primarily to counteract the toxic action of poisonous agents and thus have an important role in the treatment of poisoning. Antidote availability is crucial for the poisoned patient; it is important that hospitals keep antidotes in stock to treat these patients. Most antidotes are expensive, infrequently used, and have short shelf-lives.

Differences in job retention in a supported employment program Chinook Clubhouse.

This is a retrospective study comparing two groups of adults with severe mental illnesses in a clubhouse program, who were employed from October 1995 to June 1999. Long-Term Workers, (n = 22) were those who have held a job for over one year duration, while Short-Term Workers, (n = 20) were those who were not able to hold a job for more than a year. Data was gathered through focus groups, and individual interviews.

[Methemoglobinemia--causes, diagnosis and treatment].

Background: Methaemoglobinaemia is an infrequent condition. It can be congenital or be induced by several toxic compounds. In methaemoglobin (metHb) the iron in the haem moiety of haemoglobin is oxidized from the ferrous (Fe2+) to the ferric state (Fe3+).

[Follow-up of Souter elbow prostheses].

27 patients (30 elbows) treated with Souter elbow prosthesis replacement were examined at a follow-up study. 26 patients had rheumatic arthritis. The mean observation time was five years (2-10 years).

Anomalous nerve anatomy at the wrist?

Background And Aims: The common course of the ulnar and median nerve in the carpal tunnel has been described previously on two occasions. The aim of the study was to explain the cause of two main nerve trunks in the carpal tunnel found at an operation.

Material And Methods: A patient was treated with open reduction and internal fixation for a volar Barton's fracture of the distal radius.

Enteric-coated and plain naproxen tablets in osteoarthritis; tolerability and efficacy.

The aim of this 8 week study, was to compare the tolerability and efficacy of enteric-coated (ECT) and plain naproxen tablets (PT). Ninety eight patients (mean age 66 years) with osteoarthritis were included in a randomized, multi-centre, double-blind, cross-over study. Response variables were monitored at 2 week intervals for the duration of the study.

Comparison of bone reactions to coated tricalcium phosphate and pure titanium dental implants in the canine iliac crest.

Titanium and TCP-coated implants were compared after insertion in the canine iliac crest. Observation time was 14 wk. Evaluation included pull-out tests, energy dispersive X-ray analysis, and histologic examination of in situ, undemineralized implants.

Effects of acetylsalicylic acid on intramuscular bone matrix implants and composite grafts in rats.

Antigen-extracted, autolyzed, demineralized bone matrix and bone matrix combined with isogeneic bone marrow (i.e., a composite graft) were placed in the musculature of young male rats.

Bone changes after castration in rats. A model for osteoporosis.

Bone changes 6-12 weeks after castration have been studied in 25 female and 27 male middle-aged rats. Castrated female rats gained more weight than their controls, but had decreased bone density and calcium and hydroxyproline content per cm3 bone volume of tibia. Castrated male rats did not differ from controls regarding body weight and the bone parameters.

Bone fixation of ceramic-coated and fiber titanium implants. A study in weight-bearing rats.

We compared the fixation of glass ceramic-coated titanium and fiber titanium implants using a simple weight-bearing model in rats. The chemical composition of the glass ceramic was similar to 45S5F Bioglass. One hundred and eight male Wistar rats were operated on.

Osteogenesis promoted by bone matrix combined with marrow. Titanium implants studied in rats.

We evaluated the bone-forming potential of isogeneic bone marrow combined with antigen-extracted, autolyzed allogeneic bone matrix (AAA bone a.m. Urist).

Effects of acetylsalicylic acid and naproxen on the mechanical and biochemical properties of intact skin in rats.

Acetylsalicylic acid, ASA (150 mg/kg/12 h), and naproxen (20 mg/kg/12 h) were administered to young male rats for 9 and 18 days. The doses were set to provide serum concentrations comparable with anti-inflammatory steady state levels in humans. Mechanical tests were performed on skin from the back of the rats.

Effects of acetylsalicylic acid and naproxen on bone resorption and formation in rats.

The influence of acetylsalicylic acid (ASA) (150 mg/kg/12 h) and naproxen (20 mg/kg/12 h) on bone metabolism in young male rats has been studied. The doses were chosen to provide serum concentrations comparable with ordinary anti-inflammatory steady-state levels in humans. After the rats had been prelabeled with collagen- and mineral-tracing radioisotopes the rats received the drugs by gavage twice a day for 9 and 18 days.

Bone ingrowth into weight-bearing porous fiber titanium implants. Mechanical and biochemical correlations.

Bone ingrowth into weight-bearing porous fiber Ti-6Al-4V implants in rat tibias was assessed for the amount, composition, and mineralization rate 3, 12, and 26 weeks after implantation. The data were compared with the ipsi- and contralateral metaphyseal controls and related to the ultimate bending stresses of the distal bone/implant interfaces. From the 3rd to the 12th week there was rapid bone ingrowth and also marked decline in mineralization rate of the ingrowing bone.

Effects of acetylsalicylic acid and naproxen on the mechanical properties of intact femora in rats.

The influence of acetylsalicylic acid (ASA) and naproxen on growing bones was studied. Young male rats were used. The drugs were administered via gastric gavage twice a day for 9 or 18 days.

Effects of acetylsalicylic acid and naproxen on the synthesis and mineralization of collagen in the rat femur.

The influence of acetylsalicylic acid (ASA) and naproxen on the biochemical properties of intact growing femora in young male rats was studied. The medication periods were 9 and 18 days. At an ASA dose of 150 mg/kg/12 h the rate of collagen synthesis and the rate of mineral incorporation decreased and were impaired by about 10% compared with controls after 18 days.

Effects of acetylsalicylic acid on heterotopic bone resorption and formation in rats.

The effects of acetylsalicylic acid (ASA) on bone metabolism have been studied in a bone transplantation model using radioisotopic and biochemical parameters. Isografts (femora) from infant inbred rats, extensively prelabeled with collagen and mineral-tracing radioisotopes, were transplanted to muscle pouches in young male rats. Bones from the opposite side of the donor rats served as nonimplanted reference bones.