Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming.

DNA methylation is an important epigenetic mechanism that helps define and maintain cellular functions. It is influenced by many factors, including environmental exposures, genotype, cell type, sex, and aging. Since age is the primary risk factor for developing neurodegenerative diseases, it is important to determine if aging-related DNA methylation is retained when cells are reprogrammed to an induced Pluripotent Stem Cell (iPSC) state.

Effect of High Molybdenum Diet on Copper Status, Growth Performance, Blood Metabolites, Select Liver and Kidney Minerals, and Immune Responses of Boer Crosses.

This study examined the effects of elevated molybdenum (Mo) in goat diets on the growth, blood parameters, and immune responses in goats. Eighteen Boer crosses goats (BW = 25.6 ± 1.

Differential methylation analysis in neuropathologically confirmed dementia with Lewy bodies.

Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population. We performed genome-wide DNA methylation mapping of cerebellar tissue from pathologically confirmed DLB cases and controls to study the epigenetic profile of this understudied disease. After quality control filtering, 728,197 CpG-sites in 278 cases and 172 controls were available for the analysis.

Maternal and perinatal outcomes in women conceiving after bariatric surgery: A cohort study.

Obesity in women, a global issue, is being widely managed with bariatric surgery worldwide. According to recommended guidelines, pregnancy should be avoided for 12 to 24 months following surgery due to various risks. We assessed if surgery-to-conception time has a relation with pregnancy outcomes taking into account gestational weight gain.

Levels of Salmonella enterica and Listeria monocytogenes in Alternative Irrigation Water Vary Based on Water Source on the Eastern Shore of Maryland.

Irrigation water sources have been shown to harbor foodborne pathogens and could contribute to the outbreak of foodborne illness related to consumption of contaminated produce. Determining the probability of and the degree to which these irrigation water sources contain these pathogens is paramount. The purpose of this study was to determine the prevalence of Salmonella enterica and Listeria monocytogenes in alternative irrigation water sources.

Dietary mitigation of enteric methane emissions from ruminants: A review of plant tannin mitigation options.

Methane gas from livestock production activities is a significant source of greenhouse gas (GHG) emissions which have been shown to influence climate change. New technologies offer a potential to manipulate the rumen biome through genetic selection reducing CH production. Methane production may also be mitigated to varying degrees by various dietary intervention strategies.

Influence of tannin-rich pine bark supplementation in the grain mixes for meat goats: Growth performance, blood metabolites, and carcass characteristics.

The objective was to evaluate the use of condensed tannin (CT)-rich ground pine bark (PB) in grain mixed diets on meat goat growth performance, blood metabolites, and carcass characteristics. Twenty four Kiko crossbred () growing male kids (BW = 36.9 ± 2.

Influence of elevated protein and tannin-rich peanut skin supplementation on growth performance, blood metabolites, carcass traits and immune-related gene expression of grazing meat goats.

The aim of the present study was to define whether elevated rumen-undegradable protein (RUP) and tannin-rich peanut skin (PS) supplementation would affect animal growth performance, average daily gain (ADG), blood metabolites, carcass traits associated with lipogenic and immune-related gene expressions in meat goats grazing winter wheat (WW). Thirty-six Kiko-crossbreed male goats at approximately 6 months of age were blocked by body weight (BW; 25.6 ± 1.

Potential role of rumen microbiota in altering average daily gain and feed efficiency in meat goats fed simple and mixed pastures using bacterial tag-encoded FLX amplicon pyrosequencing1.

Cost-effective and feasible production system of meat goats requires that grazed forages are converted to profitable goat meat product. However, there are studies as how altering forage type influences ruminal fermentation parameters and animal growth performance, and interact with microbiota in meat goats. Our objective for current study was to examine whether the comparative abundance of the Bacteroidetes (B) and Firmicutes (F) bacterial phyla in meat goats fed simple and mixed forages influenced average daily gain (ADG) and rumen fermentation parameters.

Nano-sunscreens - a double-edged sword in protecting consumers from harm: viewing Australian regulatory policies through the lenses of the European Union.

Nanotechnology has the potential to bring about revolutionary changes in manufacturing products, including sunscreens. However, a knowledge gap between benefits and detriments of engineered nano-materials used in sunscreens exists, which gives rise to safety concerns. This article is concerned with the protection of consumers without impairing the embellishment of this promising technology.

Comparative aspects of plant tannins on digestive physiology, nutrition and microbial community changes in sheep and goats: A review.

Comparative aspects of plant tannins on digestive physiology, nutrition and microbial community in sheep and goats are discussed in the context of differences due to feed intake, digestibility, utilization of nutrients and microbial community. The purpose of this review was to present an overview of the potential benefits of tannin-containing diets for sheep and goats and specie differences in their response to tannins. It is well established that moderate level of tannins in the diet (3%-4% tannins DM) can precipitate with soluble proteins and increase protein supply to the sheep, but comparative aspects of tannin-containing diets in sheep and goats on animal performance, digestive physiology, rumen microbial changes and potential benefits to sustainable animal production by those compounds have received little attention.

Non-24-Hour Sleep-Wake Circadian Rhythm Disorder in a Sighted Male With Normal Functioning.

This is a rare case of non-24-hour sleep-wake rhythm disorder in a sighted male with normal functioning. The patient, a 23-year-old doctorate graduate student, presented with difficulty falling asleep and excessive daytime sleepiness. He reported variable sleep and wake times.

Reducing liver function tests for statin monitoring: an observational comparison of two clinical commissioning groups.

Background: Current liver function testing for statin monitoring is largely unnecessary and costly. Statins do not cause liver disease. Both reduction in test frequency and use of a single alanine transaminase (ALT) rather than a full seven analyte liver function test (LFT) array would reduce cost and may benefit patients.

Sleep Apnea in Hurler Syndrome: Looking Beyond the Upper Airway.

This case involves a 13-month-old male with Hurler syndrome. Due to oxygen desaturations during sleep, this patient was referred for polysomnography, which revealed severe mixed sleep apnea (apnea-hypopnea index [AHI] 72 events/h). Because sleep apnea in patients with Hurler syndrome is frequently attributed to upper airway obstruction, he was referred to otolaryngology.