Publications by authors named "Sol de la Pena"
Multiple infections by EBV, HCMV and Helicobacter pylori are highly frequent in patients with chronic gastritis and gastric cancer from Southwest Mexico: An observational study.
Medicine (Baltimore)
January 2019
Article Synopsis
- The study investigates the relationship between Helicobacter pylori (H. pylori) and two viruses, Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV), and their roles in chronic gastritis and gastric cancer among Mexican patients.
- Results show high frequencies of EBV and HCMV co-infections alongside H. pylori, with up to 92.3% of gastric cancer patients also infected with EBV.
- The findings suggest a potential synergistic effect of these pathogens in promoting chronic inflammation that may lead to gastric cancer, though specific H. pylori genotypes were not linked to EBV or HCMV infections.
Background: iodine contributes to maintain the balance of the reduced and oxidized species and is also required for thyroid hormones synthesis as triiodothyronine (T3), which regulates energy metabolism in adults. Increased body mass index (BMI) is associated with inflammatory markers, oxidative stress, and abnormalities in adipocytokines secretions that are associated with obesity and chronic disease.
Objective: the aim of the study is to investigate the association between ioduria, oxidative stress, total antioxidant status, adiponectin and interleukin-1 (IL-1) with BMI in healthy adults.
Background: During progression of gastric cancer (GC), degradation of the extracellular matrix is mediated by the matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs): changes in the expression of these have been related to unfavorable prognosis in GC.
Objective: To analyze the expression of certain MMPs and TIMPs in chronic superficial gastritis (SG) and GC.
Methods: The expression of MMPs and TIMPs was determined using qRT-PCR; the expression was classified, using threshold cycle (C(T)) values, as very high (C(T) ≤ 25), high (C(T) = 26-30), moderate (C(T) = 31-35), low (C(T) = 36-39), or not detected (C(T) = 40).
Aim: To assess expression of matrix metalloproteinases 2 (MMP2) and MMP9 in gastric cancer, superficial gastritis and normal mucosa, and to measure metalloproteinase activity.
Methods: MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain reaction. Normalization was carried out using three different factors.
Gastric cancer is the second leading cause of cancer-associated mortality in the world. Prognosis in patients with gastric cancer is difficult to establish because it is commonly diagnosed when gastric wall invasion and metastasis have occurred. Currently, some members of the extracellular matrix metalloproteinases have been identified, whose expression in gastric tumor tissue is significantly elevated compared to healthy gastric tissue.
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