Publications by authors named "Sol Seo"
Article Synopsis
- Type 2 diabetes is a major global health issue linked to obesity and metabolic syndrome, often modeled in research using high-fat diet-fed C57BL/6J mice.* -
- This study found that a 4-week high-fat diet led to metabolic syndrome in mice, showing increased obesity, elevated cholesterol, C-peptide, and blood glucose levels.* -
- By using fasting blood glucose tests and glucose tolerance tests, researchers identified clear stages of progression from metabolic syndrome to pre-diabetes, with body weight gain over 16.23 g in 12 weeks serving as a potential indicator for predicting type 2 diabetes.*
Article Synopsis
- Porcine islet transplantation may serve as a viable alternative to human islet transplantation, especially in immunosuppressed patients needing retransplantation.
- A study evaluated a second infusion of porcine islets in nonhuman primates using a specific immunosuppression regimen, which included medications like anti-thymocyte globulin and sirolimus for maintaining immune response.
- Results showed that all nonhuman primates remained normoglycemic post-retransplantation, with good graft survival and one monkey achieving insulin independence for over 237 days, indicating the effectiveness of the treatment without serious side effects.
Article Synopsis
- - The study aimed to explore the brain's structural and functional connectivities in neurologically healthy patients with end-stage renal disease (ESRD) using graph theory, while also assessing cognitive impairment prevalence among them.
- - 40 ESRD patients, 40 healthy controls, and 20 disease controls underwent advanced brain imaging and cognitive assessments to compare their brain connectivity and cognitive functions.
- - Results showed ESRD patients had lower global brain connectivity and about 70% experienced cognitive impairment, with a significant link between connectivity levels and cognitive function, suggesting brain network changes could be related to cognitive impairment in these patients.
Objective: The aim of this study was to investigate the alterations of thalamic nuclei volumes and intrinsic thalamic networks in patients with juvenile myoclonic epilepsy (JME) compared to healthy controls.
Methods: We enrolled 50 patients with JME and 42 healthy controls. We obtained structural volumes of the individual thalamic nuclei based on T1-weighted imaging and performed intrinsic thalamic network analysis using graph theoretical analysis.
Purpose: The aim of this study is to investigate the changes in the volume of individual thalamic nuclei in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS).
Methods: We enrolled 80 TLE patients with HS and 40 healthy controls. All of the subjects underwent 3D T1-weighted imaging.