Effects of melengestrol acetate on reproduction in the Beagle bitch.

Melengestrol acetate orally given to bitches at dose levels of 200 mug or more each day effectively inhibited estrous activity for a treatment period of 243 days and a lapsed period of more than 400 days from the preceding estrous period. The 100-mug dose of the drug, given orally once a day, starting immediately after the bitches were bred or late in gestation, had no effect on conception, pregnancy, or parturition. Gestation was prolonged in bitches given melengestrol acetate starting 1 day after breeding.

Evaluation of selected compounds for estrus control in the bitch.

Steroidal and nonsteroidal compounds were evaluated for estrus inhibition in the bitch. Mibolerone, an anabolic steroid, was effective and appeared to be safe. The remaining compounds lacked efficacy or had extensive side effects, or both.

Antigenicity of sodium carboxymethyl cellulose with or without 9-fluoroprednisolone acetate in the adult cow.

Multiple intramuscular injections of sodium carboxymethyl cellulose with or without 9-fluoroprednisolone acetate were not antigenic in the cow, as measured by anaphylactoid response or delayed hypersensitivity.

Lack of genetic control of the lymphatic pathway. Studies on rats.

The lymphatic route from the testis to the cisterna chyli is studied in two inbred and one random bred strain of rats. The pathway varied similarly in all three groups with no indication of genetic control.

Histologic evaluation of gallbladder in progestogen-treated bitches.

Adverse histologic effects were not observed in the gallbladder mucosa of selected bitches with endometrial hyperplasia experimentally induced by administration of exogenous medroxyprogesterone acetate.