[Clinico-laboratory and seroepidemiological examinations of children immunized with live measles vaccine prepared from genetically homogeneous strain Moscow-5].

The results of the clinico-laboratory and epidemiological study of a newly developed live measles vaccine obtained from strain Moscow-5, genetically homogeneous and cloned from strain JI-16, are presented. The data indicate that the vaccine obtained from strain Moscow-5 is safe and possesses low reactogenicity and high immunological potency, thus meeting all requirements for vaccinal preparations.

[Short-latency somatosensory evoked potentials in injuries of the cervical division of the spinal cord].

Short-latent cortical potentials and induced potentials (IP) recorded from the cervical spine in response to electrical stimulation of the median nerve on the wrist were studied in patients with injury to the cervical parts of the spine and spinal cord. The changes in the pronounced character of the somatosensory induced potentials (SSIP) proved to be more marked than those in the controls. A group of patients with considerable increase of peak N1 and corresponding increase of the time of conduction along the central nervous system (up to 20 msec) was distinguished.

[Amino acid metabolism in liver tissue during the consumption of qualitatively different proteins].

To evaluate changes in the liver ability to metabolize amino acids during intake of different proteins, the content of free amino acids was measured in the blood of the portal and liver veins of rats fed krill protein and casein. After 48 h of fasting the animals were given a suspension of krill protein and casein at a rate of 540 mg protein per 100 g bw. After 0.

[Attempt at objective evaluation of pain and analgesia during stimulation of the posterior columns in patients with spinal cord lesions].

In a group a patients with a pain syndrome in spinal cord injury electric stimulation of n. medianus causes the appearance of a component of a somatosensory induced potential (IP) which is a high-amplitude superficial-positive oscillation with a latent peak period of 200-280 mc. A similar oscillation is revealed in a group of healthy individuals in response to nociceptive stimulation of the skin on the forearm.

[Principles and methods of hygienic evaluation of new protein products].

Modern approaches to the study of the quality of new protein products are reviewed. It is suggested that the food value of the products (organoleptic properties, the composition of nutrients, biological value) and their safety for the animal body should be examined. A possible chronic toxic and sensitizing action of new protein products, their effects on reproductive function, and mutagenic and cancerogenic action were studied in animal experiments.

[Use of a method of recording somatosensory evoked potentials to evaluate the intensity of painful stimulation and the effectiveness of analgesic stimulation].

The authors propose a modified variant of experimental pain stimulation with the attendant registration of somatosensory evoked potentials (EPs) induced by electrocutaneous stimulation via electrodes placed on the ulnar surface of the lower arm. The amplitude of EPs taken from the cranial surface directly correlates with the subjective sensation of pain. These EPs represent superficial positive vibrations with the peak latent period of 240 +/- 23 msec, which are most expressed in leads with saggital electrodes.

[Acute angle x-ray scattering by phospholipid membranes after treatment with valinomycin].

It has been found by means of small-angle X-ray analysis of oriented bilayers of synthetic dimyristoyl phosphatidyl choline that the introduction of valinomycin modifies their structure and these modifications depend on the phase state of lipid.

An anticancer drug prospidine: failure to reveal antimitotic and clastogenic action on regenerating mouse liver.

Prospidine is an anticancer drug used in oncological practice in the USSR. It is characterized by only a slight toxicity and the absence of such side-effect as the hemopoiesis suppression. The mechanism of tumor growth inhibition by prospidine is still open to question.

[Disorders of higher cortical function and EEG features in patients with spinal cord lesions].

Combined electroencephalographic and neuropsychic studies of 60 patients showed the variable nature of the functional brain disorders associated with spinal cord impairments at the cervical, thoracic and lumbar-sacral levels. Changes in the EEG criteria of brain function were reflected in an altered character of the principal psychic processes. The results obtained are statistically significant.

[Phase separation in dipalmitoyl phosphatidylcholine bilayers induced by ionophores and binary electrolytes].

Thermotropic behavior of unsonicated aqueous dispersion of dipalmitoyl phosphatidylcholine (DPPC) has been studied by scanning microcalorimetry and fluorescent probe method. Phase separation in the lipid bilayers was observed for systems containing ionophores (valinomycin, dinactin) and 1 : 1 electrolytes (NaCl, KCl, RbCl, CsCl). The ratio of lipid phases coexisting in the systems appeared to be dependent on the concentration of the electrolytes.

[Levels of adenylic system components (ATP, ADP, AMP) and cAMP during development of Blastocladiella emersonii].

Concentrations of ATP, ADP, AMP, cAMP as well as pyruvate and glucose-6-phosphate were measured in B. lastocladiella emersonii cells developing via RS morphogenetic pathway. They varied significantly in the course of development (1.

Kinetics of cellular proliferation in regenerating mouse liver pretreated with the alkylating drug dipin.

The effect of prior exposure to the alkylating drug 1,4-Bis[N,N'-di(ethylene)-phosphamide] piperazine (Dipin) on the cell cycle progression in a regenerating mouse liver is reported, using cytological, autoradiographical and DNA-cytophotometrical methods. In Dipin-treated animals 3H-TdR pulse labelled nuclei appeared 22 h after the partial hepatectomy, followed by a rapid rise in labelling index to a very high level between 43-54 h, and then by a gradual decline to 72 h. Four injections of 3H-thymidine at 16 h intervals resulted in 89% labelling of hepatocytes at 72 h.

[Effect of the alkylating agent dipin on the induced proliferation of hepatocytes. I. The kinetics of the cell population].

The alkylating drug dipin was injected to mice 2 hours before a partial hepatectomy. Liver regeneration was characterized by a decrease of the intensity of 3H-thymidine label, an increase of the labeled cell index, absence of mitoses, constant number of binuclear cells. The analysis of these data has shown that dipin causes a sharp (more than by 2 times) increase of the S-period and prolonged (up to 6--20 days) blocking of cells in the G2-period.