Segment Anything in Optical Coherence Tomography: SAM 2 for Volumetric Segmentation of Retinal Biomarkers.

Optical coherence tomography (OCT) is a non-invasive imaging technique widely used in ophthalmology for visualizing retinal layers, aiding in the early detection and monitoring of retinal diseases. OCT is useful for detecting diseases such as age-related macular degeneration (AMD) and diabetic macular edema (DME), which affect millions of people globally. Over the past decade, the area of application of artificial intelligence (AI), particularly deep learning (DL), has significantly increased.

[WEAK COMBINED MAGNETIC FIELDS ADJUSTED TO THE PARAMETRIC RESONANCE FOR Ca2+ INTENSIFY DYSTROPHIN SYNTHESIS IN MDX MICE SKELETAL MUSCLES AFTER CELL THERAPY].

The mdx mice are an X-linked myopathic mutants, an animal model for human Duchenne muscular dystrophy (DMD). Mdx mice muscles are characterized by high level of striated muscle fibers (SMF) death followed by regeneration. As a result most SMFs of mdx mice have centrally located nuclei.

[Gypsy moth Lymantria dispar L. in the South Urals: Patterns in population dynamics and modelling].

The analysis is conducted on population dynamics of gypsy moth from different habitats of the South Urals. The pattern of cyclic changes in population density is examined, the assessment of temporal conjugation in time series of gypsy moth population dynamics from separate habitats of the South Urals is carried out, the relationships between population density and weather conditions are studied. Based on the results obtained, a statistical model of gypsy moth population dynamics in the South Urals is designed, and estimations are given of regulatory and modifying factors effects on the population dynamics.

[The concept of the development of the otorhinolaryngological service in Moscow under conditions of modernization of the healthcare system and single-channel funding].

This paper highlights the complex of organizational and socio-economic measures designed to modify the healthcare system in the city of Moscow, improve the quality of medical aid, and ensure its availability for the urban population. The proposed methods were developed based on the results of analysis of the data obtained in the course of checking the work of the otorhinolaryngological services of the city, analysis of effectiveness of using the hospital stock in the therapeutic and prophylactic facilities of Moscow.

Idiopathic scoliosis, growth zones, magnetic therapy.

Background: The study has been performed to investigate the influence of pulsed magnetic field on the bone growth plates to get new grounds of magneto therapy in AIS treatment.

Materials And Methods: Were used methods of "strong" and "weak" pulsed magnetic fields influence.

Results: Application of pulsed magnetic field causes an authentic inhibition of chondrocytes' active proliferation processes, decreases the index of labeled nuclei, indicating the suppression of DNA synthesis, takes place an increase in the unit weight of the more "mature" differentiated chondrocytes.

[Theoretical analysis of recompression-based therapies of decompression illness].

Theoretical analysis is concerned with the benefits of oxygen, air and nitrogen-helium-oxygen recompression schedules used to treat decompression illness in divers. Mathematical modeling of tissue bubbles dynamics during diving shows that one-hour oxygen recompression to 200 kPa does not diminish essentially the size of bubble enclosed in a layer that reduces tenfold the intensity of gas diffusion from bubbles. However, these bubbles dissolve fully in all the body tissues equally after 2-hr.

Malingering in a correctional setting: the use of the Structured Interview of Reported Symptoms in a jail sample.

The ability to detect malingering in the correctional setting is of paramount importance. The burgeoning jail and prison population combined with statutory requirements for the provision of mental health treatment require that only those most in need receive these services. Several structured assessments have been developed to assist in the identification of individuals more likely to be feigning psychiatric symptoms.

Categorization of aggressive acts committed by chronically assaultive state hospital patients.

Objective: This study examined factors motivating inpatient aggression in a sample of chronically assaultive state hospital patients.

Methods: Inpatients who had committed three or more assaults over a one-year period were identified by using an incident report database. Aggressive episodes were categorized as impulsive, organized, or psychotic by using a procedure for classifying assaultive acts based on record review.

[Experimental study of magnetic field influence on transitory instability of display image].

The article presents results of experimental study that determined threshold level of external magnetic field causing no flashing effect and spectral distribution of image instability, if general and local influence of magnetic field on display.

[The synthesis of phosphates of long-chain omega-hydroxyalkyl esters of 11-deoxyprostaglandin E1].

Di(p-methylbenzyl) phosphates of omega-hydroxyalkyl esters of 11-deoxyprostaglandin E1 were synthesized from disubstituted 1,10-decane and 1,22-docosane derivatives for studying permeability of bilayer membranes. The English version of the paper.

[The possibilities of arifon in the combined therapy of unstable stenocardia in persons with arterial hypertension].

The authors studied the effect of arifon on vascular-platelet hemostasis in patients with unstable angina pectoris and hypertension. It was established that arifon addition to standard treatment leads to a decrease of platelet aggregation. A degree of spontaneous aggregation under arifon administration reduced to 30.

[Effect of a 50 Hz magnetic field on rat behavior depends on the direct current component].

The influence of extremely low frequency magnetic field on rats behavior (working memory, learning, social activity) was examined. Rats were exposed to magnetic fields at three different conditions: exposure 1-50 Hz, 46 mT; DC 65 mTl; exposure II-50 Hz, 46 mTl; DC 14-17 mTl; Exposure III-sham. Field related changes were observed after exposure I: the increase of error rate in Y-maze performance, shorter adaptation time in instrumental performance, the decrease of aggression and sociability, enhancement of the defence reactions.

[Total synthesis and properties of prostaglandins. XXXVIII. Synthesis of 11-deoxyprostaglandin-E1 derivatives with amino acids and amines].

In order to study the physiological functions of 11-deoxyprostaglandin E1-alpha, a series of its amide derivatives with amino acids and some amines were synthesized using mixed anhydride technique. The myotropic properties of newly synthesized compounds were investigated.

[Total synthesis and properties of prostaglandins. XXXI. Synthesis of pyranylated and glycosidated omega-hydroxyalkyl ethers of 11- deoxyprostaglandin E1].

Four methods of the synthesis of model glycosides with 11-deoxyprostaglandin E1 and a connecting polymethylene chain as the aglycone are compared. Interaction of potassium salt of prostaglandin PG with omega-iodoalkylglycosides is the most promising approach.

[Total synthesis and properties of prostaglandins. XXIV. Synthesis of glycerides with prostaglandin acyl residues].

Synthesis of a number of model triglycerides and lysoglycerides bearing the acyl moieties of 11-deoxyprostaglandin E1, and palmitic acid residues has been carried out.

[Complete synthesis and properties of prostaglandins. X. Hydroxyl-containing esters of 11-deoxyprostaglandin E1].

Hydroxyl-containing 11-deoxyprostaglandin E1 esters were synthesised by using the methods of mixed anhydrides and nucleophilic displacement.

[Pharmacokinetics of rifampicin administered intravenously to pulmonary tuberculosis patients].

Pharmacokinetics of rifampicin studied in 15 patients after its intravenous administration in a dose of 10 mg/kg was described by a two-compartment model. The drug levels in serum and urine were determined with a chemical method. At the moment of the infusion discontinuation the maximum drug levels in serum averaged to 14.

Analysis of difference spectra of protonated DNA: determination of degree of protonation of nitrogen bases and the fractions of disordered nucleotide pairs.

The titration curves of nitrogen bases and fractions of disordered nucleotide pairs are obtained during DNA protonation. It is shown that purine bases are the first sites of the DNA double helix protonation. The cytosine protonation is due to proton-induced conformational transition within GC pairs with the sequence proton transfer from (N-7) of guanine to (N-3) of cytosine.

[Effect of inhibitors of microsomal hydroxylation on endogenous respiration of Torulopsis candida cells].

The effect of inhibitors of microsomal cytochrome P-450 on endogenous respiration and the redox state of components in the electron transport chain was studied in the cells of Torulopsis candida. SKP-525 A and methyrapone in the presence of preliminarily added cyanide (or antimycin A) almost completely inhibited endogenous respiration of the cells irrespective of the growth phase of the culture. The effect of these inhibitors on endogenous respiration and the reduction state of pyridine nucleotides, flavoproteins and cytochromes b, c and a + a3, at all of the studied growth phases, was similar to that of hydroxamic acids, the inhibitors of the mitochondrial alternative oxidase system.

[Electron transport chains of Torulopsis candida].

The systems of electron transport to oxygen and other acceptors were analyzed during endogenous respiration of Torulopsis candida resting cells taken at the logarithmic phase of growth of the culture in a medium containing glucose and hexadecane. The following electron transport chains were shown to function in the cells growing both on glucose and hexadecane: (1) the main (phosphorylating) respiration chain inhibited by cyanide and antimycin A and comprising flavoproteins and cytochromes b, c and a+a3; (2) the cyanide resistant electron transport chain inhibited by hydroxamic acids (it seems to function more intensively in the cells grown on glucose); (3) the chain of electron transport to H2O2 which is blocked with antimycin A and includes flavoproteins, cytochromes b and c, and apparently cytochrome c peroxidase; (4) the chain(s) containing cytochrome P-450 and found in the microsomal fraction of yeast cells grown on hexadecane.