[Influence of multiple insufficiency of vitamin D and B group vitamins, calcium and magnesium in the diet of rats on micronutrient sufficiency and plasma biochemical indicators].

The lack of vitamins D, B group, calcium and magnesium is common for the diet of the Russian population. It has been previously demonstrated that that the elimination of B vitamin deficiency is a necessary condition for the implementation of vitamin D biological functions. of the research was to assess the effect of a combined deficiency of vitamins D and B group, calcium and magnesium in the diet of rats on biomarkers of micronutrient sufficiency and plasma biochemical indicators.

[Efficiency of vitamin D deficit correction depending on rats' supply with B vitamins].

Despite the presence of combined deficiency of vitamins D and group B among the population of Russia, the intake of cholecalciferol is often recommended without correcting the supply with B group vitamins, which are involved in ensuring the biological functions of vitamin D. of the study was to compare the effectiveness of vitamin D deficit correction by replenishing its content in the diet to an adequate level without eliminating the deficit of B vitamins and by restoring vitamin D level in combination with B vitamins. .

[Biomarkers of vitamin status in obese school children].

Inadequate intake of vitamins, noted in children with obesity, reduces the immune system activity, contributes to the metabolic disorders aggravation and may result in comorbidity. of the work was to study sufficiency with vitamins and carotenoids of children with obesity. Examination of vitamin D, B, C, A, E and β-carotene status in 50 children (male 36.

[The study of the association between rs2228570 polymorphism of gene and vitamin D blood serum concentration in the inhabitants of the Russian Arctic].

Genetic factor plays a significant role in nutrient deficiency development, including vitamins, by present time the association between several genetic polymorphisms and vitamin deficiency in the different regions of the world has been established. The aim of this study was to evaluate the possible association between VDR FokI polymorphism and vitamin D sufficiency in the population of the Yamal-Nenets Autonomous District of the Russian Federation. The group of participants included 172 people, among them 133 women and 39 men aged 20 to 75 years old.

[Vitamin status of rural residents, living in Russian Arctic].

The aim of this cross-sectional observational study was to estimate vitamin D, B2, A, E, β-carotene (BC) status in rural residents, living in Russian Arctic (Yamal-Nenets Autonomous Area). 216 healthy adults (166 women, 50 men, 45.4±0.

[Assessment of vitamin status of the workers of Samara thermal power plant according to data on vitamin intake and their levels in blood].

Sufficiency of 58 employees of a thermal power plant (47 men and 11 women aged 21 to 64 years, body mass index - 27.0±5.8 kg/m), with vitamins A, E, D, B, B, folic acid and carotenoids (content in the blood plasma) and vitamin C (urinary excretion) was conducted in winter (February 2015).

[The vitamin status of pregnant women in Moscow: effect of multivitamin-mineral supplements].

Examination of the vitamin status of 102 pregnant women (19-41 years old) from Moscow (gestational age 6-38 weeks) in winter and spring 2015 has been conducted. The lack of vitamin B2 (blood serum level of riboflavin <5 ng/ml), D (25(OH)D level <30 ng/ml) and β-carotene (<20 mg/dL) occurred in 49-66% of pregnant women. The percentage of persons with reduced serum levels of vitamin B6 (<4.

[Correction of the combined vitamin deficiency in growing rats fed fiber enriched diets with different doses of vitamins].

The effect of 5% dietary wheat bran (WB) on the correction of combined vitamin deficiency by two doses of vitamins (physiological and enhanced) has been analyzed using a rat model (8 groups, n = 8/group). Vitamin deficiency in male weanling Wistar rats (58.1 ± 0.

[Assessment of efficiency of dietotherapy with addition of a vitamin-mineral complex in patients with diabetes mellitus type 2].

The influence of diet inclusion of vitamin and mineral complex (VMC), potassium and magnesium in the form of asparaginate on micronutrient status, body composition and biochemical parameters in patients with diabetes mellitus type 2 (DM2) has been investigated. 120 female patients with DM2 and obesity of I-III degree (mean age - 58 +/- 6 years) have been included in the study. The patients were divided into two groups: main group (n = 60) and control group (n = 60).

Efficiency of various vitamin doses for polyhypovitaminosis correction in rats.

A 5-fold decrease of the content of vitamin mixture in the ration and exclusion of vitamin E from this mixture over 4 weeks led to a significant growth delay in rats initially weighing 58.1±0.5 g, but was inessential for the growth rates of animals weighing 107.

[Effect of wheat bran fiber on vitamin status of weaning rats with alimentary polyhypovitaminosis].

Effect of wheat bran on the vitamin status of rats adequately provided with vitamins or insufficiently supplied with vitamins has been investigated. 32 male Wistar weaning rats (initial body mass--49-67g) were randomly divided into 4 groups and fed with complete semi-synthetic diet, containing 100 or 20% of vitamin mixture with or without addition of wheat bran (5% of diet mass) for 35 days. The animals of the control group received 100% of vitamin mixture without adding of wheat bran; 2 group--received those diet with wheat bran; 3 deficient group--20% of vitamin mixture with full exclusion of vitamins E, B1 and B2; 4 group--20% of vitamin mixture and wheat bran.

[Correction of polyhypovitaminosis in rats, having standard and enriched with polyunsaturated fatty acids family omega-3 diets with different doses of vitamins].

The efficiency of the correction of combined alimentary vitamin deficit in male Wistar rats (body weight 90-121 g) fed standard diet or enriched with omega-3 polyunsaturated fatty acids diet (by replacing sunflower oil (4.5% of the diet) with linseed oil) with different doses (physiological and enhanced) of vitamins has been investigated. The control group of animals (n = 12) received a complete semisynthetic diet during all experimental period (42 d).

[Enrichment effect of vitamin-deficient diet of rats by polyunsaturated fatty acids omega-3 on vitamin biomarkers and antioxidant status].

Using the model of combined vitamin deficiency based on 5-fold reduction of the amount of vitamin mixture in semi-synthetic diet and on vitamin E exclusion from the mixture, the influence of omega-3 polyunsaturated fatty acids (PUFA) on vitamin and antioxidant status has been investigated. The enrichment of rat diet with PUFA was achieved by replacing of sunflower oil (4.5% of the diet) on linseed oil.

[Influence of hypocaloric diet with addition of a vitamin-mineral complex on status of patients with obesity 1st and 2nd degrees].

Addition of a vitamin-mineral complex (VMC) to a standard hypocaloric diet leads to a positive dynamics of antropometric characteristics in patients with obesity 1st and 2nd degrees which is comparable to effectiveness of standard dietotherapy (dietary treatment) traditionally used in complex treatment of obesity. Addition of 1,8 mg of vitamin B2 as part of VMC to a hypocaloric diet is shown to be inadequate in eradication of marginal provision of riboflavin when using diets reduced in calories.

[Food fortified with vitamins: the history and perspectives].

The recommended daily intakes of vitamins in different countries have been compared. The data on consumption of vitamins and vitamin status are submitted. It is noted that since 2008 the values of recommended daily intakes of vitamin-antioxidants C and E and folate in Russia as in other countries has been significantly increased.

[Influence of specialized carbohydrate protein product enrich vitamins and minerals status of patients with gastrointestianals pathology and osteopenia].

It has been shown that inclusion of the specialized product containing 50% from recommended daily consumption of calcium, 20% of protein, 17-60% of 11 mineral substances and 11 vitamins in the diet of patients suffering from diseases of gastroenteric tract and osteopenia within 6 months lead to increasing of bone mineral density while it has not liquidated the existing vitamin B2 and vitamin D deficiency. The data obtained confirm the expediency of the development of specialized products of the set chemical composition intended for a concrete category of patients, and their inclusion in the diet.

[Efficiency of diet therapy containing carbohydrate-protein product enriched with vitamins and minerals in patients with cardiovascular diseases, obesity, and osteopenia].

It has been shown that inclusion of the specialized product containing 50% from recommended daily consumption of calcium, 20% of protein, 17-60% of 11 mineral substances and 11 vitamins in the diet of patients with cardiovascular diseases, adiposity and osteopenia within 6 months has prevented seasonal deterioration of vitamin D sufficiency and age reduction of mineral bone density while it has not liquidated the existing vitamin B2 deficiency. The data obtained confirm the expediency of the development of specialized products of the set chemical composition intended for a concrete category of patients, and their inclusion in the diet.

[Evaluation of inclusion of specialized carbohydrate-protein product with vitamins and mineral substances in the diet therapy of gastrointestinal and osteopenia diseases].

It has been shown that inclusion of the specialized product containing 50% from recommended daily consumption of calcium, 20%--of protein, 17-60%--of 11 mineral substances and 11 vitamins in the diet of patients suffering from diseases of gastroenteric tract and osteopenia within 6 months lead to increasing of bone mineral density while it has not liquidated the existing vitamin B2 and vitamin D deficiency. The data obtained confirm the expediency of the development of specialized products of the set chemical composition intended for a concrete category of patients, and their inclusion in the diet.

[To the 20th anniversary of the Chornobyl accident study of vitamin status and provision with micro- and macroelements of limited groups of people at different time periods since the accident at Chornobyl nuclear power plant].

Results of the study of the provision with vitamins and some micro- and macroelements of limited groups of people, who suffered from the accident at the Chornobyl nuclear power plant (ChNPP), which have been carried out by Ukrainian and Russian scientists during various periods after the accident, are generalized in the paper. Persons which participated in liquidation of the accident and lived during the accident in the territory, adjoining to Pripyat (the Kyiv region, town of Slavutich), people which worked at the object "Shelter" and ChNPP were involved in the inspection. It was noted, that in 1-4 years after the ChNPP accident in blood of liquidators the biochemical parameters displaying security of their organism by vitamins A and B1, remain lower in comparison with the same parameters in a group of relatively healthy persons which were not affected by the accident (control), that testifies to stable metabolic disturbance in the organism of people under irradiation influence.

[To 20-years anniversary of Chernobyl catastrophe: an attempt to study the vitamin, calcium, iron and selenium status of children and adult population in Slavutich and to correct elicited deficiencies].

The article concisely illustrates the vitamin and mineral state of population of town of Slavutich, including personal of Chernobyl Nuclear Power Station, children of pre-school age and pregnancy women, studied in 1992. Vitamins and minerals deficiency in the main of C and B vitamins and selenium was revealed in all the studied groups. Appropriate measures were developed and introduced to eliminate the detected dusturbances; but however some unsolved problems remained.

[Study of the state of lipid peroxidation system: antioxidant protection during the use of soy oil in patients with ischemic heart disease and hypertension].

Usage of antisclerotic diet with PUFA n-3 from soy oil in patients with IHD and HBP resulted in positive dynamic of clinic manifestation, blood lipids and coagulogramms of the patients. The decrease of intensity of lipid peroxidation was also revealed. The results showed that soy oil may be recommended for preventive and treatment diets.

[Functional role of vitamin K].

Three basic functions of vitamin K in organism are considered. Besides (vitamin K-dependent) posttranslational modification of Ca-binding proteins, this vitamin can operate via vitamin D hormonal system, and can directly influence membranes.

[Influence of lead on metabolism of vitamins B group in alimentary iron deficient rats].

Experimentally induced lead poisoning especially under simultaneous iron deficit leads to the development of secondary thiamine insufficiency. Erythrocyte riboflavin content and erythrocyte glutathion reductase and aspartate aminotransferase activities have been demonstrated to be increased. Lead treatment is accompanied with the increase of urinary excretion of riboflavin, 4-pyridoxic acid and 1-vtthylnicotinamide in rats fed with adequate diet.

[Vitamin status of the population from regions suffering from the accident at the Chernobyl power plant, and its correction with multivitamins "Duovit" and "Undevit" and multivitamin premix 730/4 of the firm "Roche"].

There was no differences of principle in vitamin status of population living in 'zones of strict control' (Brjanskaja, Mogilevskaja, Gomel'skaja regions) and Moscow's population. Mean indices of vitamin C, A, E, B1 and carotene status in children and adults were not differed in two groups of population. But vitamin B2 and niacin status in Moscow's adults were worse.

[Features of B group vitamin metabolism and criteria for providing them to children suffering from celiac disease].

The investigation into the relationship between the concentration of vitamins B, the blood activity of vitamin B-dependent enzymes and the urinary excretion of their metabolites in 14 children of both sexes whose age was 4.5-10 years and who suffered from celiac disease has characterized their metabolic features. The criteria for vitamin B1 provision of these children differ from those in healthy children of the same age: the normal value of TDP effects is achieved with higher thiamine excretion which is more than 12 micrograms/h.