Transition metal-catalyzed synthesis of new 3-substituted coumarin derivatives as antibacterial and cytostatic agents.

The aim of this study was to synthesize new coumarin-based compounds and evaluate their antibacterial and antitumor potential. Using transition metal-catalyzed reactions, a series of 7-hydroxycoumarin derivatives were synthesized with aliphatic and aryl moiety attached directly at C-3 of the coumarin ring and through the ethynyl or 1,2,3-triazole linker. The 3-substituted coumarin derivative bearing bistrifluoromethylphenyl at the C-4 position of 1,2,3-triazole () showed strong and selective antiproliferative activity against cervical carcinoma cells.

Uncommon Non- Yeasts in Healthy Turkeys-Antimicrobial Susceptibility and Biochemical Characteristic of Trichosporon Isolates.

The microbiota of the gastrointestinal tract of humans and animals is inhabited by a diverse community of bacteria, fungi, protozoa, and viruses. In cases where there is an imbalance in the normal microflora or an immunosuppression on the part of the host, these opportunistic microorganisms can cause severe infections. The study presented here evaluates the biochemical and antifungal susceptibility features of spp.

A PROSPECTIVE STUDY TO ANALYZE THE SPECIFICITY OF CHLAMYDIAL HEAT SHOCK PROTEIN (CHSP60) ANTIBODIES TO DIAGNOSE TUBAL INFERTILITY.

Objective: The aim: To investigate the utility of testing for chlamydial heat shock protein 60 (CHSP60) antibodies in the diagnosis of tubal infertility.

Patients And Methods: Materials and methods: All the collected samples were assayed for IgM and IgG antibodies to chlamydia trachomatis and chlamydial heat shock protein 60 (CHSP60) by using immunofluorescence and enzyme-linked immunosorbent assay (ELISA) techniques, respectively.

Results: Results: There were no substantial differences between antibodies to C.

E-test Determination of Antifungal Susceptibility of Species Isolated from Turkeys.

Introduction: Candida species are a natural component of the intestinal tract microflora, but in favourable conditions they can cause superficial, mucosal, or even systemic candidiasis. Poultry production might be a source of human drug-resistant yeast infections, including spp. The limited data concerning the antifungal susceptibility of poultry isolates prompted us to carry out research to determine the susceptibility of isolates from turkey intestinal tracts.

Onshore mud volcanoes as a geological source of mercury: Case study from the Kerch Peninsula, Caucasus continental collision zone.

Three mud volcanoes (MVs) in the Kerch Peninsula were studied as a geological source of mercury. The study focused on total mercury (THg) concentrations in MV waters, mud masses and plants colonizing MV areas; gaseous elemental mercury (GEM) in the atmosphere above MVs; and sulfide mercury (HgS) and HgCl species in representative samples of mud masses. THg concentrations in the illite-smectite mud masses ranged from 38 to 920 ng/g.

[The preparation of patients with urinary stone disease to extracorporeal shock-wave lithotripsy].

Unlabelled: The treatment of urinary stone disease is one of the most urgent and complex issue in modern urology. Citrate is one of the most important natural urinary inhibitors of stone formation. In this regard, the drugs containing citrate sodium and potassium are being actively used.

The Prevalence of Yeast and Characteristics of the Isolates from the Digestive Tract of Clinically Healthy Turkeys.

This study was undertaken to explore the issue of yeast species prevalence in colonizing the gastrointestinal tract of healthy turkeys. The samples were collected from the beak cavity, crop, and cloaca of 5-wk-old turkeys, cultured and classified using morphological, biochemical, and genetic analysis based on ITS1-5.8rRNA-ITS2 fragment sequencing.

Investigation of the correlation between virulence factors and genotypic profiles of Candida albicans isolated from turkeys.

Candida albicans exists as an element of the normal flora in the skin, mucosa, and gastrointestinal tract, which is the principal reservoir for this organism. When the delicate balance in the host-yeast relationship is tipped in favour of the microorganism by antimicrobial treatment, illness, or other debilities of the host, fungi may overgrow and cause disease, such as candidiasis. The aim of this study was to analyse three virulence factors, haemolysin, proteinase, and phospholipase, with the genotypic profiles of C.

Carbon and Nitrogen Speciation in N-poor C-O-H-N Fluids at 6.3 GPa and 1100-1400 °C.

Deep carbon and nitrogen cycles played a critical role in the evolution of the Earth. Here we report on successful studying of speciation in C-O-H-N systems with low nitrogen contents at 6.3 GPa and 1100 to 1400 °C.

[Unusual presentation of an right atrial myxoma].

We report a case of a right atrial myxoma initially presenting as an acute anteroseptal MI. A 46-year-old man has been admitted to our ICU with chest pain started five hours before. The initial ECG showed sinus rhythm 56/min with normal atrioventricular conduction and ST segment elevation of 3-4 mm in leads V1-V2, T wave inversion pattern in leads I, II, aVL, V3-V6 with loss of R- voltages in leads V2, V3 all suggestive of an anterior wall myocardial infarction.

Acute myocardial infarction following blunt chest trauma due to sea traffic accident.

Myocardial infarction as a complication of blunt chest trauma has been reported most commonly in victims of car accidents. Other cases have been very rarely reported. To our knowledge, sea traffic accident as the cause of coronary artery injury has not been described.

Infective endocarditis of aortic valve during pregnancy: a case report.

Infective endocarditis during pregnancy is uncommon but very serious. A 31-year-old woman in the 36th week of second pregnancy was admitted to a hospital because of fever, weakness, chest pain, painful skin over her right leg and dyspnea. Transthoracic echocardiography showed aortic valve vegetation and severe aortic regurgitation.

Rupture of a right sinus of valsalva aneurysm into the right ventricle during vaginal delivery: a case report.

A case is reported of a right sinus of Valsalva aneurysm rupture into the right ventricle during vaginal delivery in a 34-year-old healthy woman in her third pregnancy. Pregnancy was carried to term and a healthy baby was delivered vaginally. On day 7 following vaginal delivery she was admitted to hospital for dyspnea and cough, with clinical signs of severe heart failure.

[Echocardiographic assessment of diagnosis and prognosis of biopsy-proven amyloid cardiomyopathy].

Amyloid cardiomyopathy is myocardial infiltrative disorder which mostly has been seen as the consequence of systemic amiloidosis. The diffuse global myocardial infiltration of nonfunctional amyloid displaces the contractile myocites giving rice to relaxation abnormality and diastolic dysfunction of restrictive or congestive type of both ventricles, but more frequently with right-sided congestion, while systolic left ventricular function deteriorates late in disease process. We report a patient with amyloid cardiomyopathy and nephrotic syndrome underlying primary amiloidosis.

[Significance of transesophageal echocardiography in the diagnosis of atrial tumor].

The Aim Of Work: To assess the diagnostic accuracy and clinical significance of transesophageal echocardiography (TEE) in the diagnosis of atrial tumors. The authors own experiences with use of TEE images in the assessment of atrial tumors are reported.

Patients And Methods: The study group consisted of 18 consecutive patients (9 women and 9 men), age range 40-72 years (mean age 60.

[Functional changes in the lower part of the urethra in women following hysterectomy and hysterectomy-ovariectomy ].

Functional deterioration of a lower part of the urethra has been observed in woman after the operation. It has been partially recovered at the late postoperative period. Further studying pre- and postoperative function of a lower part of the urethra is of importance to develop a strategy of prevention and treatment functional deterioration of a lower part of the urethra in woman after the operation of hyster- and hysterovaroactomia.

Echocardiographic features of adult tetralogy of Fallot with natural palliative correction by patent ductus arteriosus.

A thirty-year-old man with the diagnosis of the tetralogy of Fallot and patent ductus arteriosus was admitted to our hospital because of a syncope. He reported no previous symptoms. We diagnosed adult tetralogy of Fallot, which included all four characteristic anomalies: ventricular septal defect, overriding aorta, pulmonary artery stenosis, and right ventricular hypertrophy.

Prevalence and clinical significance of left atrial spontaneous echo contrast detected by transesophageal echocardiography.

The prevalence and clinical significance of left atrial spontaneous echo contrast (SEC) were studied in patients undergoing transesophageal echocardiography (TEE). The study group included 290 consecutive patients (186 male and 104 female, aged 17-86 years, mean age 56.1 +/- 12.

Serum total, LDL, HDL cholesterol and triglycerides related to age, gender and cigarette smoking in patients with first acute myocardial infarction.

The aim of this study was to examine relationships between total cholesterol, LDL, HDL cholesterol, triglycerides and age, gender, and cigarette smoking in 190 patients (132 men and 58 women) aged 34-87 years with first AMI. The control group included 103 patients (57 men and 46 women) aged 29-90 years without a history of angina pectoris or AMI. High total cholesterol (over 5.

[History of psychiatric facilities in the Silesian region in the 19th century].

A historiographic paper in which the authors--psychiatrists--deal, based on research in archives, with the period preceding by approximately 100 years the opening of the psychiatric sanatorium in Opava. The beginnings of institutional care of the mentally sick in the Silesion region were in 1841 and were associated with the construction of an "asylum" on the grounds of the newly built hospital in Opava, a small house for 20-24 patients kept under inhuman conditions. An advance was the provisional arrangement involving the lease of a castle in Albrechtice for 36 and finally 90 patients in 1873.