Publications by authors named "Sokhna Keita-Alassane"
Article Synopsis
- Validating animal pain models is important for improving research and treatment responses, and this study focused on the effects of light exercise combined with pain relief on female rats with induced joint instability.
- Rats were divided into different groups to assess the impact of exercise alone or with the analgesics pregabalin and carprofen over 56 days, showing that exercise increased sensory thresholds and had a synergistic effect with pain relief treatments.
- Histological analysis revealed that while exercise might benefit pain sensitivity, it also led to more significant joint damage compared to sedentary rats, highlighting the complexity of using exercise in pain models for better clinical outcomes.
Article Synopsis
- - The study aimed to assess how estrogen, specifically 17β-estradiol, affects pain perception by using a rat model of surgically induced osteoarthritis (OA).
- - Female rats were ovariectomized and received either estrogen or a placebo before developing OA; pain sensitivity was measured through weight-bearing and paw withdrawal tests, alongside spinal neuropeptide levels analysis.
- - Results showed that estrogen treatment led to less pain sensitivity and altered the levels of certain neuropeptides, suggesting estrogen may have beneficial effects on pain in the context of OA and highlighting the need to consider gender differences in pain studies.
Abundant corneocyte surface protrusions, observed in patients with atopic dermatitis with filaggrin loss-of-function mutations, are inversely associated with levels of natural moisturizing factors (NMFs) in the stratum corneum. To dissect the etiological role of NMFs and filaggrin deficiency in surface texture alterations, we examined mouse models with genetic deficiencies in the synthesis or degradation of filaggrin monomers for NMFs, cell stiffness (elastic modulus) and corneocyte surface protrusion density (dermal texture index). Five neonatal and adult mouse models carrying inactivating mutations of SASPase (Sasp), filaggrin (Flg and Flg), filaggrin-hornerin (FlgHrnr), and bleomycin hydrolase (Blmh) were investigated.
View Article and Find Full Text PDFFilaggrin (FLG) and corneodesmosin (CDSN) are two key proteins of the human epidermis. FLG loss-of-function mutations are the strongest genetic risk factors for human atopic dermatitis. Studies of the epidermal distribution of canine FLG and CDSN are limited.
View Article and Find Full Text PDFCerebral malaria (CM) is the most severe manifestation of human malaria yet is still poorly understood. Mouse models have been developed to address the subject. However, their relevance to mimic human pathogenesis is largely debated.
View Article and Find Full Text PDF