Publications by authors named "Soji Soman"
Nanoengineered Platform-Based Microenvironment-Triggered Immunotherapy in Cancer Treatment.
Front Biosci (Landmark Ed)
October 2024
The immune system and cancer cells interact intricately during the growth of tumors, and the dynamic interplay between immune activation and suppression greatly influences the cancer outcome. Natural killer cells (NK), cytotoxic T lymphocytes (CTLs) and Dendritic cells (DC), employ diverse mechanisms, to combat cancer. However, the challenges posed by factors such as chronic inflammation and the immunosuppressive tumor microenvironment (TME) often hinder immune cells' ability to detect and eliminate tumors accurately.
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- Lactoferrin nanoparticles (LF-NPs) are being studied as a new method for drug delivery and imaging, particularly for tracking cancer-related sentinel lymph nodes.
- The nanoparticles were developed through thermal treatment to achieve a specific size and were characterized for stability, biocompatibility, and safety through various tests.
- The successful radiolabeling with technetium-99m and subsequent biodistribution studies in rats indicate LF-NPs' potential for effective targeted drug delivery and further biomedical applications.
Article Synopsis
- Cancer poses a major global health challenge, leading to a need for new treatment methods, where microspheres are a prominent drug delivery system due to their biocompatibility and ability to release drugs over time.
- The review explores various microsphere conjugates, including polymers and inorganic substances, that are used to deliver cancer therapies directly to tumors while minimizing side effects.
- It emphasizes the potential of these conjugates to combine different treatment strategies, such as chemotherapy and immunotherapy, to enhance cancer treatment effectiveness.
Stimuli-responsive nanoplatforms have been popular in controlled drug delivery research because of their ability to differentiate the tumor microenvironment from the normal tissue environment in a spatiotemporally controllable manner. The synergistic therapeutic approach of combining cancer chemotherapy with photothermal tumor ablation has improved the therapeutic efficacy of cancer therapeutics. In this study, a UiO-66 metal organic framework (MOF)-based system loaded with doxorubicin (DOX), surface decorated with the photothermal agents indocyanine green (ICG) and polydopamine (PDA), and conjugated with transferrin (TF) was successfully designed to operate as a responsive system to pH changes, featuring photothermal capabilities and target specificity for the purpose of treating breast cancer.
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- The research focuses on synthesizing zirconium-based metal-organic frameworks (UiO-66) using a defect engineering approach, which enhances their potential applications and examines their toxicity.
- Various characterization techniques, including FTIR, Raman spectroscopy, XRD, and TEM, confirmed the formation and properties of the synthesized nanomaterials, while additional tests explored their stability and drug loading capabilities using 5-fluorouracil.
- Toxicity assessments were conducted through hemolysis and cell viability assays, supported by in vivo studies on Wistar rats, and bio-distribution analysis was performed using radiolabeling to understand how these frameworks behave in biological systems.
Background: In the current work, co-rotating twin-screw processor (TSP) was utilized to formulate solid crystal suspension (SCS) of carvedilol (CAR) for enhancing its solubility, dissolution rate, permeation and bioavailability using mannitol as a hydrophilic carrier.
Methods: molecular dynamics (MD) studies were done to simulate the interaction of CAR with mannitol at different kneading zone temperatures (KZT). Based on these studies, the optimal CAR: mannitol ratios and the kneading zone temperatures for CAR solubility enhancement were assessed.
Topical drug delivery holds immense significance in dermatological treatments due to its non-invasive nature and direct application to the target site. Organogels, a promising class of topical drug delivery systems, have acquired substantial attention for enhancing drug delivery efficiency. This review article aims to explore the advantages of organogels, including enhanced drug solubility, controlled release, improved skin penetration, non-greasy formulations, and ease of application.
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- - Ferroptosis is a new type of cell death that occurs when oxidative damage outpaces protective responses, showing promise for cancer treatment, and it is distinct from apoptosis and necrosis.
- - Current molecular therapies struggle with inducing ferroptosis due to issues like poor solubility and rapid metabolism; however, nanotechnology uses iron-based nanomaterials to effectively trigger this process by increasing iron and reactive oxygen species levels in cells.
- - The review discusses the mechanisms of ferroptosis, the role of cell organelles in cancer therapy, and categorizes the various nanomaterials that can induce ferroptosis to aid in reducing tumor growth, along with practical design suggestions for therapeutic applications.
Article Synopsis
- MXenes are advanced 2D materials with exceptional mechanical, electrical, and thermal properties, making them significant in nanotechnology, particularly for biomedical applications like cancer treatment.
- Their unique characteristics enable MXene conjugates to be effective in anticancer therapies and offer capabilities for bioimaging and biosensing.
- The review discusses various synthesis methods, the potential benefits and risks related to toxicity, and the future challenges and opportunities for clinical use of these nanoconjugates in medicine.
Article Synopsis
- Andrographolide (AG), a compound from Andrographis paniculata known for its health benefits, struggles with poor solubility and bioavailability, which limits its therapeutic use.
- This study focused on creating and optimizing AG-loaded nanoliposomes (AGL) and enhancing them with mannosylated chitosan (MCS) to improve AG's absorption when taken orally.
- Results showed that the MCS-AGL formulations provided sustained drug release, significantly improved AG's permeability, and enhanced its bioavailability and stability in vivo, highlighting MCS's potential as a valuable tool for boosting poorly soluble drugs.
Article Synopsis
- Female breast cancer is the most commonly diagnosed cancer and leading cause of cancer deaths among women, highlighting the need for innovative treatment methods due to the downsides of traditional therapies.
- Two-dimensional black phosphorus nanosheets (BPNSs) are emerging as promising alternatives for cancer treatment and diagnosis, due to their favorable properties like high drug loading efficiency, biocompatibility, and exceptional optical capabilities.
- The review covers various aspects of BP nanomaterials including their synthesis, targeting strategies for therapy, and applications in breast cancer treatment, while addressing current challenges and possible future directions in the field.
Tumours are the second leading cause of death globally, generating alterations in biological interactions and, as a result, malfunctioning of crucial genetic traits. Technological advancements have made it possible to identify tumours at the cellular level, making transcriptional gene variations and other genetic variables more easily investigated. Standard chemotherapy is seen as a non-specific treatment that has the potential to destroy healthy cells while also causing systemic toxicity in individuals.
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- * Biomimetic NPs show potential in various biomedical applications such as drug delivery, immune evasion, imaging, cancer targeting, and improving sensitivity to phototherapy.
- * This review discusses the types of biomimetic NPs, their methods of fabrication, applications in medicine, and recent advancements in biohybrid delivery systems that utilize cell membranes.