Publications by authors named "Soichiro Kon"
Article Synopsis
- The study investigated the relationship between the URAT1 gene, specifically the rs505802 SNP, and mortality in a group of 1,596 participants from Japan, focusing on how this genetic factor might contribute to hyperuricemia.
- Results indicated that individuals with the GG genotype had a higher mortality risk compared to those with the AG or AA genotypes, with significant findings even after adjusting for factors like age and health conditions, showing a hazard ratio of 2.23.
- The research concluded that the URAT1 genetic predisposition is linked to increased mortality rates in the population studied, suggesting this association may involve mechanisms separate from serum uric acid levels.
Background: To evaluate renal function, the indices of estimated glomerular filtration rate (eGFR) obtained using several equations, including the Japanese versions of the serum creatinine-based MDRD equation (eGFRcreat), Chronic Kidney Disease Epidemiology Collaboration equation (eGFR-EPI), and serum cystatin C-based equation (eGFRcys), are utilized. This study prospectively examined the association between these eGFR values and all-cause mortality during a 12-year observational period in a community-based population.
Methods And Results: The subjects of this study were 1312 participants undergoing a health checkup, aged ≥40 years.
Background: Chronic kidney disease is a significant risk factor for end-stage kidney disease, cardiovascular events, and premature death. However, the prognostic value of low estimated glomerular filtration rate (eGFR) in the elderly is debatable.
Methods: We determined eGFR using the Japanese equation in 132,160 elderly subjects (65-75 years) who attended the special health checkup (Tokutei-Kenshin) in 2008 and investigated the association between baseline eGFR and 5-year all-cause and cardiovascular mortality.