Publications by authors named "Soichi Yamada"
Altered gut microbiota is linked to systemic lupus erythematosus (SLE), but its association with disease development, disease activity, and post-intervention changes remains unclear. We compared new-onset SLE (NOSLE, n = 25), SLE in remission (RemSLE, n = 30), and healthy controls (HC, n = 30) cross-sectionally and conducted the first longitudinal analysis of NOSLE patients (n = 22) from pre-intervention to remission over 12 months. Significant β-diversity differences were observed in both NOSLE and RemSLE compared to HC, but not between NOSLE and RemSLE.
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- The Wnt/β-catenin signaling pathway is implicated in glucocorticoid-induced osteoporosis (GIOP), and previous studies suggested that inhibiting sclerostin could provide a treatment option.
- The study aimed to evaluate the effectiveness of romosozumab (ROMO), compared to denosumab (DMAb) and bisphosphonates (BP), in increasing bone mineral density (BMD) in patients with rheumatic diseases undergoing glucocorticoid therapy.
- Results showed that ROMO significantly improved lumbar spine BMD after 12 months, indicating that it is a promising treatment for patients with GIOP.
Lipid mediators have been suggested to play important roles in the pathogenesis of rheumatoid arthritis (RA). Lipidomics has recently allowed for the comprehensive analysis of lipids and has revealed the potential of lipids as biomarkers for the early diagnosis of RA and prediction of therapeutic responses. However, the relationship between disease activity and the lipid profile in RA remains unclear.
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- Fibrosing interstitial lung disease (ILD) arises from impaired healing of lung tissue damage, with cellular senescence playing a key role in its progression, although the exact mechanisms remain unclear.
- In a study involving murine models, it was found that p21-senescent type 2 alveolar epithelial cells (AEC2) rapidly appear after lung injury and persist, while p16-senescent AEC2 develop more slowly and in fewer numbers.
- The research suggested that inflammatory cells and various factors produced by senescent AEC2 may contribute to both the onset and worsening of lung fibrosis, indicating a complex interplay in the disease process.
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- CX3CL1 (fractalkine) is linked to rheumatoid arthritis (RA) and blocking it has shown to help reduce arthritis symptoms in both mice and a clinical study.
- In a study with SKG mice, which have similar lung disease features to human RA-ILD, researchers tested an anti-CX3CL1 antibody but found no significant impact on lung fibrosis or overall BALF cell count.
- The treatment did lead to a notable decrease in M1 macrophages, which are inflammatory cells, compared to M2 macrophages, hinting that the CX3CL1-CX3CR1 pathway plays a role in M1 macrophage infiltration in RA-ILD.
Objectives: To assess the renal and non-renal efficacy of mycophenolate mofetil (MMF) in Japanese patients with systemic lupus erythematosus (SLE).
Methods: We conducted a retrospective study to assess the renal and non-renal efficacies of MMF in Japanese patients with systemic lupus erythematosus (SLE). We analyzed 14 patients with lupus nephritis (LN) who were given MMF, and 13 patients who received monthly intravenous cyclophosphamide (IVCY) as induction therapy, and a further 19 patients without LN who were treated with MMF, and 13 patients who took tacrolimus (TAC) to reduce glucocorticoid dosages.
Background: Adipokines are bioactive hormones secreted by adipose tissues. Resistin, an adipokine, plays important roles in the regulation of insulin resistance and inflammation. Resistin levels are known to be increased in the serum and synovial fluid of rheumatoid arthritis (RA) patients.
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