Publications by authors named "Sohyeon Gwon"
Strict social isolation and physical distancing measures implemented during the COVID-19 pandemic had significant implications for the psychological well-being of middle-aged and older adults. This study aimed to investigate factors associated with depressive symptoms during the pandemic period among individuals who reported no significant depressive symptoms before the pandemic. Individuals from the Korean Longitudinal Study of Aging without a previous report of significant depressive symptoms across Waves 6 (2016) and 7 (2018) were investigated for the development of depressive symptoms in Wave 8 (2020).
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- This study investigates the efficacy, safety, and pharmacokinetics of an 80 mg daily dose of osimertinib in patients with leptomeningeal metastases (LMs) who have previously been treated with other EGFR tyrosine kinase inhibitors (TKIs).
- A total of 73 patients were treated, and findings include a median overall survival of 15.6 months and a 51.6% objective response rate, indicating substantial effectiveness in controlling the disease.
- The results support the use of osimertinib as a promising treatment option for patients with EGFR-mutated non-small cell lung cancer who develop LMs, highlighting its significant intracranial activity and manageable safety profile.