Publications by authors named "Sohn T"
Background: Cardiovascular disease (CVD) can lead to unplanned care in patients with cancer, which may affect their prognosis and survival. We aimed to compare the rates, timing, and length of stay of unplanned CVD readmission in hospitalized patients with and without cancer.
Methods: This study used the 2017-2018 Nationwide Readmissions Database to identify adult hospitalized patients with and without cancer.
Article Synopsis
- Lymphoepithelioma-like carcinoma (LELC) is a rare form of early gastric cancer, characterized by younger patients and a greater occurrence of tumors located in the upper stomach.
- Despite having a higher rate of deep submucosal invasion compared to well or moderately differentiated gastric cancers, LELC shows lower rates of lymphatic invasion and lymph node metastasis (LNM).
- The study suggests that endoscopic submucosal dissection could be an effective treatment option for early-stage LELC, particularly for tumors limited to the mucosa or shallow submucosa due to the low risk of metastasis.
Article Synopsis
- - A retrospective review from 2015 to 2023 identified 21 cases of diabetic ketoacidosis (DKA) linked to SGLT2 inhibitors, with 57.1% presenting as euglycemic DKA (euDKA) and 42.9% as hyperglycemic DKA (hyDKA).
- - Most DKA cases occurred in type 2 diabetes patients, with hyDKA individuals exhibiting worse glycemic control, lower C-peptide levels, and more severe renal impairment, leading to complications like hemodialysis in some cases.
- - Common symptoms included nausea and weakness, with contributing factors for DKA being infections, dehydration, and improper insulin use, highlighting the need for
Background And Aims: When treating undifferentiated-type early gastric cancer (UD-EGC) that is limited to the mucosa (clinically T1a), endoscopic submucosal dissection (ESD) can be considered if the tumor is 2 cm or less and is not ulcerated. However, there is insufficient evidence to determine the relationships between tumor size and oncological safety of ESD in UD-EGC.
Methods: The pathology reports of Korean patients who were diagnosed with UD-EGC (n = 5286) were retrospectively reviewed.
Context: Thyrotoxicosis requires accurate and expeditious differentiation between Graves' disease (GD) and thyroiditis to ensure effective treatment decisions.
Objective: This study aimed to develop a machine learning algorithm using ultrasonography and Doppler images to differentiate thyrotoxicosis subtypes, with a focus on GD.
Methods: This study included patients who initially presented with thyrotoxicosis and underwent thyroid ultrasonography at a single tertiary hospital.
Article Synopsis
- Surgery combined with chemotherapy is the standard treatment for locally advanced gastric cancer (GC) and gastroesophageal junction cancer (GEJC), but outcomes are often poor, especially in specific genetic subtypes like dMMR/MSI-high.* -
- Analysis from several clinical trials shows that patients with MSI-high tumors generally have better survival rates than those with MSS/MSI-low tumors, and that female patients with MSS/MSI-low tumors tend to live longer than their male counterparts.* -
- The study emphasizes that sex can influence the effectiveness of treatments for both MSI-high and MSS/MSI-low non-metastatic GC/GEJC, with surprisingly higher chemotherapy risks noted in females with MSI-high cancers.*
Aim: To evaluate the long-term safety and efficacy of enavogliflozin 0.3 mg/day added to metformin in patients with type 2 diabetes mellitus.
Materials And Methods: After 24 weeks of a randomized, double-blind treatment period with enavogliflozin 0.
Backgruound: Recent diabetes management guidelines recommend that sodium-glucose cotransporter 2 inhibitors (SGLT2is) or glucagon-like peptide 1 receptor agonists (GLP-1RAs) with proven cardiovascular benefits should be prioritized for combination therapy in patients with type 2 diabetes mellitus (T2DM) and established cardiovascular disease (CVD). This study was aimed at evaluating SGLT2i or GLP-1RA usage rates and various related factors in patients with T2DM and established CVD.
Methods: We enrolled adults with T2DM aged ≥30 years who were hospitalized due to established CVD from January 2019 to May 2020 at 13 secondary and tertiary hospitals in Korea in this retrospective observational study.
Article Synopsis
- Advances in chemotherapy and immunotherapy have allowed some stage IV gastric cancer patients to undergo conversion surgery after significant tumor regression from palliative chemotherapy.
- A study involving 118 patients at Samsung Medical Center evaluated various baseline and post-chemotherapy features, finding that 21 patients achieved a complete pathologic response and 97 patients were downstaged.
- Important factors for prognostic evaluation included BMI, HER2 status, and other molecular markers, suggesting that conversion surgery can be an option for more patients regardless of their initial disease severity.
Objective: Real-world-based population data about the optimal low-density lipoprotein cholesterol (LDL-C) level for preventing cardiovascular disease in very high-risk populations is scarce.
Methods: From 2009 to 2012, 26,922 people aged ≥ 40 years with type 2 diabetes mellitus (T2DM) who had a history of percutaneous coronary intervention (PCI) were analyzed. Data from the Korean National Health Insurance System were used.
Cardiovascular disease (CVD) in cancer patients can affect the risk of unplanned readmissions, which have been reported to be costly and associated with worse mortality and prognosis. We aimed to demonstrate the feasibility of using machine learning techniques in predicting the risk of unplanned 180-day readmission attributable to CVD among hospitalized cancer patients using the 2017-2018 Nationwide Readmissions Database. We included hospitalized cancer patients, and the outcome was unplanned hospital readmission due to any CVD within 180 days after discharge.
View Article and Find Full Text PDFBackground: Patients with gastric cancer often encounter impaired quality of life and reduced tolerability to adjuvant treatments after surgery. Weight preservation is crucial for the overall prognosis of these patients, and exercise and supplemental nutrition play the main role. This study is the first randomized clinical trial to apply personalized, treatment stage-adjusted digital intervention with wearable devices in gastric cancer rehabilitation intervention for 12 months, commencing immediately after surgery.
View Article and Find Full Text PDFAims: To evaluate the effect of dapagliflozin on body composition such as total body fat (BF) mass, abdominal visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) areas compared with glimepiride in Korean patients with type 2 diabetes.
Materials And Methods: This was a 52-week, multicentre, randomized, parallel-group, open-label, Phase IV (NCT02564926) study. Patients with inadequate glycaemic control (glycated haemoglobin ≥7.
Background: Clinical benefits of the meso-jejunal lymph node (MJLN) dissection in remnant gastric cancer (RGC) patients have not been fully established. Hence, in this retrospective study, we evaluated the survival benefit of MJLN dissection and prognostic significance of MJLN metastasis in RGC patients who underwent gastrojejunostomy reconstruction after their initial gastrectomy.
Methods: We retrospectively reviewed 391 patients who underwent surgery for RGC at our institution between 1996 and 2019.
Article Synopsis
- The study investigates the adherence of Korean male osteoporosis patients to denosumab treatment, highlighting concerns around poor persistence and the risk of vertebral fractures.
- Out of 294 patients, only 26.2% completed all four denosumab doses over 24 months, with many missing appointments linked to factors like age and provider specialty.
- Medical errors, improvement in T-scores, and dental procedures were common reasons for discontinuation, indicating significant barriers to long-term treatment adherence.
Background: There has been no comparison of the prognoses of Korean patients who underwent curative surgery for cancer located at the cardia or subcardia of the stomach. We performed this comparison and further investigated the prognostic significance of esophagogastric junction (EGJ) invasion in patients.
Methods: The medical records of patients ( = 511) who were diagnosed with cardia or subcardia cancer and underwent surgery between January 2010 and May 2019 were retrospectively reviewed.
Backgruound: Enavogliflozin is a novel sodium-glucose cotransporter-2 inhibitor currently under clinical development. This study evaluated the efficacy and safety of enavogliflozin as an add-on to metformin in Korean patients with type 2 diabetes mellitus (T2DM) against dapagliflozin.
Methods: In this multicenter, double-blind, randomized, phase 3 study, 200 patients were randomized to receive enavogliflozin 0.
Background & Aims: Post-gastrectomy vitamin D deficiency can result in osteoporosis and fractures, which can decrease patient quality of life and increase their socioeconomic burden. However, because there is no consensus around preoperative measurement and regular postoperative monitoring of serum vitamin D [25(OH)vitD] level for gastric cancer patients, we performed a retrospective study with a single high-volume center experience.
Methods: We reviewed a database of 614 gastric cancer patients who underwent curative gastrectomy between December 2015 and December 2019.
Background: While many studies investigated changes in working status in cancer survivors, most studies have been performed in survivors of breast cancer and few studies evaluated factors associated with changes in the working status of cancer survivors comprehensively. We aimed to evaluate the changes in the working status of cancer survivors after diagnosis and socio-demographic, clinical, work-related and psychological factors associated with it.
Methods: We conducted a cross-sectional survey of adult patients with cancer who were working at the time of diagnosis.
Article Synopsis
- The study aimed to determine the impact of preoperative blood test results on advanced stomach cancer patients and to see who benefits more from combined chemoradiotherapy versus chemotherapy alone.
- Among 1,032 patients who had surgery and were treated with either chemotherapy or chemoradiotherapy, the study narrowed down to 692 patients for analysis.
- The findings highlighted that absolute monocyte count was a strong predictor of survival outcomes, and patients with a high absolute lymphocyte count showed better recurrence-free survival when treated with combined therapy.
Background/aim: Because there are ongoing efforts to identify and develop novel drugs in the treatment of refractory gastric cancer, it is necessary to develop effective preclinical studies. Here, the preclinical efficacy of gastric tumor xenograft (GTX)-derived cell line models for the personalized treatment of gastric cancer was investigated.
Materials And Methods: Anti-cancer drugs were scanned with high-throughput screening (HTS) using pre-established GTX-derived cell lines.