Publications by authors named "Soheir A Abdel Maksoud"
Article Synopsis
- Peroxisomal disorders can be divided into peroxisome biogenesis disorders (PBDs) and single enzyme deficiencies, often causing neurological issues due to oxidative stress.
- The study involved 20 patients with these disorders, aged six months to 13 years, and compared them to 14 healthy controls while assessing their oxidative stress through various diagnostic methods.
- Results showed significantly increased levels of malondialdehyde (MDA) and nitric oxide (NO) in patients, alongside lower levels of superoxide dismutase (SOD), indicating that oxidative stress is closely linked to peroxisomal disorders and suggesting potential benefits from antioxidant treatments.
Background: The pathological mechanisms underlying peroxisomal biogenesis disorders (PBD) are not fully understood and the available therapies are not sufficient. This stresses the importance of identifying biochemical markers that reflect the extent of peroxisomal dysfunction in plasma of PBD patients.
Methods: Very long chain fatty acids VLCFAs, Phytanic acid, inflammatory markers: tumor necrosis-alpha, interleukin-6, and interleukin-2 (TNF-alpha, IL-6, and IL-2), lipid peroxidation parameter malonedialdhyde (MDA), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), and catalase activity were measured.