Publications by authors named "Soheil Sharifi"

Article Synopsis
  • - The study presents a two-phase approach to develop and characterize novel hybrid nano-photosensitizers for targeting breast cancer, integrating molecular simulations with laboratory and animal experiments for improved model accuracy.
  • - In the first phase, researchers used artificial intelligence and molecular docking to identify pharmacokinetic weaknesses and synthesized biohybrid nanoplatforms, assessing their stability in vivo.
  • - The second phase optimized photodynamic treatment variables and demonstrated that the optimized nano-photosensitizer effectively killed triple-negative cancer cells in both static and dynamic cultures, indicating a promising strategy for enhancing cancer treatment.
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The molecular dynamics of a copolymer composed of methyl methacrylate (MMA) and (2-acetoacetoxy)ethyl methacrylate (AEMA) monomers and the influence on it of intra- to intermolecular cross-links of AEMA units with ethylenediamine (EDA) was studied by combining dielectric relaxation experiments and thermal investigations. The dielectric spectra of the non-cross-linked copolymer show three dynamical processes: a slow relaxation (α) and a faster (β), both dominated by the MMA dynamics, and an even faster secondary relaxation (γ) reflecting the AEMA dynamics. Already for low cross-linking densities, the γ process is very much affected and eventually disappears, increasing the cross-linking density.

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Encapsulation of crocin (CN), having large nonlinear optical (NLO) properties, can be utilized in studies of photodynamic therapy (PDT). For this purpose, photo-physical and NLO properties of CN encapsulation with and without cell culture medium (CCM) were investigated. As well, nonlinear absorption (NLA) coefficient and nonlinear refractive (NLR) indices were found to be 10 (cm W) and 10 (cm W); respectively.

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Dye-doped droplets are known as mixtures of dyes with uniform solutions of water droplets in a continuous phase of oils with surfactants. To observe the relationship between water droplet structures and surfactant types on optical properties of dyes, a mixture of methyl orange (MO)-doped droplet prepared with benzane and hexane as oils and sodium bis(2-ethylhexyl) sulfosuccinate (AOT) as a surfactant was thus examined using Z-scan instrument, spectrophotometer, and fluorimeter in the present study. The findings revealed that nonlinear refractive (NLR) index, nonlinear absorption (NLA) coefficient, as well as fluorescence intensity of the MO had enhanced following a reduction in the droplet water content induced by changes in the non-centrosymmetric charge density distribution of this pH indicator.

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The present study investiaged the enhancement of nonlinear optical properties of Protoporphyrin IX in photodynamic therapy using nano-droplet. To this end; absorbance, fluorescence, and nonlinear optical properties of Protoporphyrin IX were examined and results showed that dye aggregation and dielectric constant of solvent could change absorbance and fluorescence spectra. According to quantum mechanical perturbation theory, dipole moment of Protoporphyrin IX in solutions of water-ethanol was extracted.

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The photophysical and nonlinear optical properties of Azophloxine in Reverse micelle (RM) and dye-surfactant interaction were studied using Z-scan, spectrophotometer, and spectrofluorometer techniques. The different range of RM sizes and oil polarity is studied. RM is a mixture of water droplet in a continuous phase of oil and its polarity depends on oil polarity.

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Dye decolorization is currently measured by the reduction of dye absorption, based on its linear optical properties in solution. However, this method is not suitable for high dye concentrations with linear attributes in the absorption spectra. In this work, nonlinear optical properties are used to study dye decolorization of Crocin and Rhodamine B treated with a bacterial laccase.

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The enhancement of the nonlinear properties of materials is an interesting topic since it has many applications in optical devices and medicines. The Z-scan technique was used to study the values of the two-photon absorption (β), second-order molecular hyperpolarizability (γ), third-order susceptibility (χ), and nonlinear refractive index (n) of Alizarin Red S in different media using a continuous-wave diode-pump laser radiation at 532 nm. For Alizarin Red S in a droplet, the β, n, χ and γ were estimated at the order of 10 cm/W and 10 cm/W, 10 m W s and 10 m W s, respectively.

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Dielectric spectroscopy as a function of temperature and pressure was used to study the secondary relaxation in poly [(phenyl glycidyl ether)-co-formaldehyde] at hydrostatic pressure up to 600 MPa and at different temperatures between 315 and 243 K. From the analysis of the isothermal measurements, we observe that the activation volume of the secondary relaxation has nonmonotonic temperature dependence with a maximum at the temperature of the glass transition at ambient pressure. An interpretation in terms of mean hole volume dispersion is proposed based on literature data.

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