Publications by authors named "Sohee Park"
Background Application of multimodal large language models (LLMs) with both textual and visual capabilities has been steadily increasing, but their ability to interpret radiologic images is still doubted. Purpose To evaluate the accuracy of LLMs and compare it with that of human readers with varying levels of experience and to assess the factors affecting LLM accuracy in answering Image Challenge cases. Materials and Methods Radiologic images of cases from October 13, 2005, to April 18, 2024, were retrospectively reviewed.
View Article and Find Full Text PDFPolymorphisms in the type A gene as determinants of the cefazolin inoculum effect in .
Antimicrob Agents Chemother
December 2024
Article Synopsis
- Plasmids with wild-type and mutant type A genes were created and introduced into a bacterial strain called RN4220, resulting in four different strains: WT-blaZ, M226-blaZ, M229-blaZ, and MB-blaZ.
- The study found that the minimum inhibitory concentration (MIC) of cefazolin was significantly lower in the strains with mutations at codon 226 (MB-blaZ and M226-blaZ) compared to the wild-type strain (WT-blaZ).
- This indicates that a mutation at codon 226 affects the bacteria's resistance to cefazolin, while the mutation at codon 229 did not have the same effect.
Article Synopsis
- - The study addresses the limitations of using undefined basement membrane extracts like Matrigel for cultivating intestinal stem cells (ISCs) by introducing a new xenogeneic-free culture dish called XF-DISC.
- - XF-DISC significantly increases the growth and maintenance of ISCs, achieving a 24-fold cell number increase within 30 days and sustaining viability over 210 days (30 passages).
- - This method allows for successful transplantation of cultured human ISCs into mouse models with intestinal injuries, fostering tissue regeneration, making it a promising approach for effective ISC therapy in human intestinal diseases.
Background: The increasing rate of excess body weight (EBW) in the global population has led to growing health concerns, including cancer-related EBW. We aimed to estimate the population attributable fraction (PAF) of cancer incidence and deaths linked to EBW in Korean individuals from 2015 to 2030 and to compare its value with various body mass index cutoffs.
Methods: Levin's formula was used to calculate the PAF; the prevalence rates were computed using the Korean National Health and Nutrition Examination Survey data, while the relative risks of specific cancers related to EBW were estimated based on the results of Korean cohort studies.
Altered representation of peripersonal and interpersonal space in psychopathology.
Clin Psychol Rev
December 2024
The space surrounding the body, and the regulation of this buffer zone play a central role in adaptive behavior, with direct implications for psychopathology. The physical distance that we choose to maintain between ourselves and others for social comfort is known as Interpersonal Distance (IPD), whereas the action space that marks the perceptual border between the self and the external world is known as Peripersonal Space (PPS ). While both IPD and PPS represent personal space, they are distinct constructs, each associated with different methodologies.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on the career development experiences of Korean medical educators using the protean career theory, which emphasizes individual-led career growth.
- Through semi-structured interviews with nine medical educators, the research utilized Interpretative Phenomenological Analysis to uncover their experiences in building careers amidst changing educational landscapes.
- Findings indicated that these educators align with the protean career model, demonstrating traits like self-direction and adaptability, while also highlighting the importance of organizational support in their career journeys.
Non-viral vectors for mRNA delivery primarily include lipid nanoparticles (LNPs) and polymers. While LNPs are known for their high mRNA delivery efficiency, they can induce excessive immune responses and cause off-target effects, potentially leading to side effects. In this study, we aimed to explore polymer-based mRNA delivery systems as a viable alternative to LNPs, focusing on their mRNA delivery efficiency and potential application in mRNA vaccines.
View Article and Find Full Text PDFHPV Vaccination Stages and Associated Factors Among Children of Immigrant Women.
Public Health Nurs
October 2024
Article Synopsis
- The study investigated factors influencing HPV vaccination among children of immigrant women in South Korea, focusing on different stages of vaccine implementation.
- Using a survey of 262 women from China, Vietnam, and Korea, researchers analyzed how social norms and perceived barriers affect vaccination intentions and initiation.
- The findings highlight that social norms strongly impact vaccination decisions, and emphasize the need for culturally tailored interventions to improve vaccination completion rates.
Article Synopsis
- The concept of peripersonal space (PPS) is crucial for distinguishing our bodily self from others and is believed to be disrupted in individuals with schizophrenia (SZ).
- A study using immersive virtual reality tested how perceived threats from approaching avatars affected the PPS of individuals with SZ and matched controls (CO).
- Results indicated that while CO could sharpen their self-boundary in response to perceived threats, SZ individuals showed a shallower response, linking it to symptoms like delusions and loneliness, highlighting the need for more research on the self-boundary regulation in SZ.
Objectives: There is still a debate regarding the prognostic implication of lymphovascular invasion (LVI) in stage I lung adenocarcinoma. Ground-glass opacity (GGO) on CT is known to correlate with a less invasive or lepidic component in adenocarcinoma, which may influence the strength of prognostic factors. This study aimed to explore the prognostic value of LVI in stage I lung adenocarcinoma based on the presence of GGO.
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- A new AI model was created to predict knee implant sizes for surgeries, making the process faster and easier for surgeons.
- The model was trained on x-ray images from 714 patients and used data augmentation to enhance training data without relying on clinical or demographic info.
- Results showed the model had high accuracy, with micro F1-scores of 0.91 for femur and 0.87 for tibia, indicating its potential to streamline preoperative procedures in knee surgeries.
Importance: The use of oral corticosteroids for prolonged periods may be associated with adverse events (AEs). Nevertheless, the risk of AEs with oral corticosteroids, especially among patients with atopic dermatitis (AD), has not been comprehensively investigated and lacks evidence on duration of treatment.
Objective: To assess the association between long-term exposure to oral corticosteroids and AEs among adult patients with AD.
Background: Dietary factors play a role in the etiology of gastrointestinal cancer. We aimed to estimate the burden of gastric and colorectal cancer that can be attributable to dietary factors in adults aged 20 years and older in Korea in 2018.
Methods: Dietary intakes in 2000 were estimated using data from the 2001, 2005, and 2007-2018 Korea National Health and Nutrition Examination Survey (KNHANES).
Article Synopsis
- The COVID-19 Vaccine Safety Research Center (CoVaSC) was created in South Korea to investigate potential links between COVID-19 vaccines and adverse events during the pandemic, with backing from health authorities.
- Traditional methods for determining causality in medical events faced limitations, prompting an update of a causality assessment framework by the National Academies of Sciences, Engineering, and Medicine (NASEM) in 2024, which uses a weight-of-evidence approach.
- This updated framework evaluates both epidemiological evidence from population studies and mechanistic evidence from biological studies, allowing for a comprehensive conclusion on causality, categorized from "convincingly supports" to "inadequate to accept or reject."
Exposure and damage caused by noise have been reported in many countries around the world. However, few nationwide studies explored the association of residential environmental noise with depressive symptoms, this study aims to examine this association. The Korean Community Health Survey at the individual-level and the Korean Environmental Noise Measurement Database at the regional-level were used.
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- - The study aimed to evaluate the risk of cardiovascular disease (CVD) in survivors of gastrointestinal (GI) cancer, as previous research on this group has been limited.
- - Data collected from the Korean National Health and Nutrition Examination Surveys showed that GI cancer survivors had a lower risk of atherosclerotic cardiovascular disease (ASCVD) compared to cancer-free individuals, especially among those who engaged in sufficient physical activity.
- - Results highlighted that adequate aerobic exercise and high quality of life scores were associated with significantly reduced ASCVD risk in GI cancer survivors, suggesting the importance of physical activity for their cardiovascular health.
Reply to Ni : Comprehensive Strategies for the Follow-Up of Interstitial Lung Abnormality.
Am J Respir Crit Care Med
September 2024
Bodily self-disturbances including anomalous embodiment of emotions are observed in psychosis-spectrum conditions. Psychosis is also associated with trauma exposure but the relationship between altered bodily experiences and trauma has not been extensively investigated in individuals at risk for psychosis (HR). We implemented a mapping task to localize felt sensations associated with trauma.
View Article and Find Full Text PDFObjective: To investigate the risk of cardiovascular events associated with commonly used dual and triple therapies of evogliptin, a recently introduced dipeptidyl peptidase-4 inhibitor (DPP4i), for managing type 2 diabetes in routine clinical practice.
Design: A retrospective cohort study.
Setting: Korean Health Insurance Review and Assessment database.
Article Synopsis
- Akkermansia muciniphila is important for gut health as it aids in gut immunity, intestinal development, and barrier integrity.
- The study focuses on a newly discovered protein, Amuc_1409, secreted by A. muciniphila, which enhances intestinal stem cell (ISC) growth and recovery in both lab models and aging male mice.
- Amuc_1409 works by interacting with E-cadherin, activating Wnt/β-catenin signaling, and is suggested as a potential biological agent for promoting gut health.
The paucity of evidence regarding the safety of gestational antipsychotic exposure has led to treatment discontinuation in pregnant women with severe mental health conditions. This systematic review and meta-analysis aimed to summarise the current evidence on the association between gestational antipsychotic exposure and attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in children (Study protocol registered in PROSPERO:CRD42022311354). Five studies included in our meta-analysis with around 8.
View Article and Find Full Text PDFObjective: This study aimed to investigate the association between gaming time and problematic game use (PGU) within a large sample of Korean male gamers and to examine the potential moderating effects of loneliness, living alone, and household size.
Methods: This study employed data from 743 male gamers from the National Mental Health Survey 2021, a nationally representative survey of mental illness conducted in South Korea. Self-reported data on the average gaming time per day, severity of PGU, loneliness, living alone, and household size were used.
Background: The diagnosis of distant metastasis on preoperative examinations for non-small cell lung cancer (NSCLC) can be challenging, leading to surgery for some patients with uncertain metastasis. This study evaluated the prognostic impact of delayed diagnosis of metastasis on patients who underwent upfront surgery.
Methods: The study enrolled patients who underwent lobectomy or pneumonectomy for NSCLC between June 2010 and December 2017 and evaluated the presence of distant metastasis before surgery.