Publications by authors named "Sohee Jo"
Zika virus (ZIKV) infection is primarily transmitted by mosquitoes and often asymptomatic in most individuals. Infection during pregnancy can lead to severe birth defects such as congenital microcephaly, and currently, there is no approved vaccine for ZIKV. Several studies are investigating the development of ZIKV vaccine using DNA and RNA as well as recombinant protein technologies; however, the outcomes thus far have not been consistently noteworthy.
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- mRNA vaccines have changed vaccinology since the COVID-19 pandemic, and lipid nanoparticles (LNPs) are important for improving mRNA delivery, but their current design needs improvement.
- Researchers are using machine learning to analyze 213 different LNPs, using various features to predict how well they can deliver mRNA after being injected into mice.
- Findings indicate that phenol is key for mRNA encapsulation, and factors like phospholipid types, N/P ratios, and carbon chain lengths significantly affect the efficiency and stability of LNPs, providing a new framework for optimizing mRNA delivery systems.
Porcine epidemic diarrhea virus (PEDV) is a coronavirus that causes acute diarrhea in suckling piglets. Although vaccines are able to reduce the incidence of PEDV infection, outbreaks of PEDV continue to be reported worldwide and cause serious economic losses in the swine industry. To identify novel antiviral sources, we identified the chestnut () inner shell (CIS) as a natural material with activity against PEDV infection .
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