Publications by authors named "Soham Ali"
Article Synopsis
- The renin-angiotensin-aldosterone system (RAAS) has implications beyond blood pressure regulation and may impact cancer development and treatment outcomes, particularly in metastatic renal cell carcinoma (mRCC).
- A study at the University of Virginia showed that patients with mRCC receiving immunotherapy (IO) who also used RAASI, like ACE inhibitors or ARBs, experienced higher rates of tumor regression.
- The research suggests a significant association between concurrent RAASI use and tumor regression among patients undergoing IO, indicating potential benefits of combining these treatments in managing mRCC.
Background: Dipeptidyl peptidase IV (DPP4) is a cell surface receptor that possesses numerous substrates implicated in tumor growth and metastasis. Prior studies have suggested an association between DPP4 inhibition and increased progression-free survival (PFS) and overall survival (OS) in colorectal and lung cancers but no benefit in breast or pancreatic cancers. However, no studies to date have explored the impact of DPP4 inhibitors (DPP4i) in patients with metastatic renal cell carcinoma (mRCC).
View Article and Find Full Text PDFMultiple sclerosis (MS) is an autoimmune demyelinating disease of the CNS that is linked with both genetic and environmental factors. A Western-style diet rich in fat and simple sugars is hypothesized as a potential factor contributing to the increased incidence of inflammatory autoimmune diseases, such as MS, in developed countries. Although the adverse effects of a high-fat diet in MS have been studied extensively, the effect of a fructose-rich diet (FRD) on MS etiology is unknown.
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