Polymorphisms of the receptor for advanced glycation end products as vasculopathy predictor in sickle cell disease.

Background: The genetic variants of the receptor for advanced glycation end products (RAGE) gene have been associated with vascular disease risk. The objective of this work was to explore the association of three single-nucleotide polymorphisms (SNPs) of RAGE gene (374T/A, 429T/C, and G82S) with vascular complications in SCD.

Methods: The study was conducted on 40 children with SCD and 40 healthy children served as controls.

AC133 expression in egyptian children with acute leukemia: impact on treatment response and disease outcome.

AC133 antigen is expressed restrictively in the immature subset of the CD34 cells. Hence, it is expected to be a valuable prognostic marker in acute leukemia. Sixty Egyptian children with acute leukemia were enrolled into this prospective study divided into 2 groups: 30 acute myeloblastic leukemia (AML) and 30 acute lymphoblastic leukemia (ALL) patients.